Conserved Protein Domain Family
STKc_PRKX_like

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cd05612: STKc_PRKX_like (this model, PSSM-Id:173703 is obsolete and has been replaced by 270763)
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), cAMP-dependent protein kinase (PKA) subfamily, PRKX-like kinases, catalytic (c) subunit. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney.
Statistics
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PSSM-Id: 173703
Aligned: 7 rows
Threshold Bit Score: 560.519
Threshold Setting Gi: 4688648
Created: 6-Sep-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ###### #            # #         #                     #               #
P51817        47 QDFDTLATVGTGTFGRVHLVKEktakHFFALKVMSIpdviRLKQEQHVHNEKSVLKEVsHPFLIRLFWTWHDerFLYMLM 126 human
P16912       272 DDYQIIKTVGTGTFGRVCLCRDriseKYCAMKILAMteviRLKQIEHVKNERNILREIrHPFVISLEWSTKDdsNLYMIF 351 fruit fly
XP_416852     54 EDLETLATVGTGTFGRVHLVKEkmgkHYFALKVMSIpdviRLKQEQHVHNEKSVLKEVnHPFLIRLFWTYHDerFLYMLM 133 chicken
XP_001627328  16 QDFELSKTLGTGTFGRVLLARDrrggEFYALKIMNIseviRLKQVEHVQNEKNILMSIeHPFIVNLLWTQHDqtFLYMLL 95  starlet sea ane...
CAG06638      35 ANLRMYSLDELDTIATVVKDKKt--rTFYALKQMKIpdviRLKQEQHVHNEKEVLTEVtHPFIIRLFWTHHDqrFLYMLM 112 Tetraodon nigro...
P49673        27 DDFDRICTIGTGSFGRVYLVQHraseQYFALKKMAIrevvSMRQTEHVHSEKRLLSRLsHPFIVKMYCASWDkyNLYMLF 106 pig roundworm
CAB41352      61 SQLERIITIGKGTFGRVELARDkitgAHYALKVLNIrrvvDMRQTQHVHNEKRVLLQLkHPFIVKMYASEKDsnHLYMIM 140 nematode
Feature 1        # #   # #   #                                # #### #         ##  #          # #
P51817       127 EYVpGGELFSYLRNrgRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDrdGHIKLTDFGFAKKLVDRTWTLCG 206 human
P16912       352 DYVcGGELFTYLRNagKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINrdGHLKITDFGFAKKLRDRTWTLCG 431 fruit fly
XP_416852    134 EYVpGGELFSYLRNmgRFNNSTGLFYSTEIICAIEYLHSKEIVYRDLKPENILLDkeGHIKLTDFGFAKKLVDRTWTLCG 213 chicken
XP_001627328  96 EYAcGGELFTYLRTagRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDrdGHVKLTDFGFAKEVHDKTWTLCG 175 starlet sea ane...
CAG06638     113 DFVpGGELFSYLRSrgRFSNTTGLFYTSEIVCAIEYLHSKEIVYRDLKPENILLDseGHIRLTDFGFAKKLSDRTWTLCG 192 Tetraodon nigro...
P49673       107 EYLaGGELFSYLRAsrTFSNSMARFYAAEIVCALQYLHSKNIAYRDLKPENLMLNkeGHLKMTDFGFAKEVIDRTWTMCG 186 pig roundworm
CAB41352     141 EFVpGGEMFSYLRAsrSFSNSMARFYASEIVCALEYIHSLGIVYRDLKPENLMLSkeGHIKMADFGFAKELRDRTYTICG 220 nematode
Feature 1        ###                          #   ###  ### #  #                                  
P51817       207 TPEYLAPEVIQSkgHGRAVDWWALGILIFEMLSGFPPFFDDnPFGIYQKILAGKIDFPRHl-dFHVKDLIKKLLVVdRTR 285 human
P16912       432 TPEYIAPEIIQSkgHNKAVDWWALGVLIYEMLVGYPPFYDEqPFGIYEKILSGKIEWERHm-dPIAKDLIKKLLVNdRTK 510 fruit fly
XP_416852    214 TPEYLAPEVIQSkgHGRAVDWWALGILIFEMLSGFPPFFDDnPFGIYQKILAGKIDFPRHl-dLYVKDLIKKLLVVdRTR 292 chicken
XP_001627328 176 TPEYLAPEIIQSkgHNKAVDWWALGILIYEMLVGYPPFFDDnPFGIYEKILSGKVEWPKHmdnTSAKDLIKKLLVHdRTR 255 starlet sea ane...
CAG06638     193 TPEYLAPEVIQSkgHGRAVDWWALGILIFEMLAGYPPFFDDnPFGIYQKILAGKLEFPRHl-dFYVKDLIKKFLVIdRAR 271 Tetraodon nigro...
P49673       187 TPEYLAPEVIGNkgHDTAVDWWSLGVLIYEMMIGIPPFRGKtLDEIYEKIILGKLRFTRSf-dLFAKDLVKKLLQVdRTQ 265 pig roundworm
CAB41352     221 TPDYLAPESLARtgHNKGVDWWALGILIYEMMVGKPPFRGKtTSEIYDAIIEHKLKFPRSf-nLAAKDLVKKLLEVdRTQ 299 nematode
Feature 1                                                       #  # 
P51817       286 RLGNmknGANDVKHHRWFRSVDWEAVPQRklkPPIVPKIAGDGDTSNFETYP 337 human
P16912       511 RLGNmknGADDVKRHRWFKHLNWNDVYSKklkPPILPDVHHDGDTKNFDDYP 562 fruit fly
XP_416852    293 RLGNmknGADDVKRHRWFRSIDWDAVPQRrlkPPIVPKVSNDGDTSNFEAYP 344 chicken
XP_001627328 256 RLGSmknGSEDVKNHKWFKVIDWNLVLQRklkPPINPKISHPGDTRNFDDYP 307 starlet sea anemone
CAG06638     272 RLGNmknGADDVKKHRWFKTVDWDAVPLRklkPPIIPKVSHEGDTSNFDVYP 323 Tetraodon nigroviridis
P49673       266 RLGNqkdGAADVMNHKWFTDIDWDDVQNMkltPPIIPTLYSNGDTGNFDSYD 317 pig roundworm
CAB41352     300 RIGCmknGTQDVKDHKWFEKVNWDDTLHLrvePPIVPTLYHPGDTGNFDDYE 351 nematode

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