3C4X,3C4W


Conserved Protein Domain Family
STKc_GRK1

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cd05608: STKc_GRK1 (this model, PSSM-Id:173699 is obsolete and has been replaced by 270759)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
Serine/Threonine Kinases (STKs), G protein-coupled Receptor Kinase (GRK) subfamily, GRK1 isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. There are seven types of GRKs, named GRK1 to GRK7. GRK1, also called rhodopsin kinase, belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease.
Statistics
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PSSM-Id: 173699
Aligned: 6 rows
Threshold Bit Score: 512.469
Threshold Setting Gi: 2996094
Created: 22-Oct-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####   #            # #                               #               ## #   # 
3C4X_A       193 LGRGGFGEVFACQMkatgKLYACKKLNKKRLKKrkgyQGAMVEKKILAKVhSRFIVSLAYAFETktDLCLVMTIMNGGDI 272 cattle
3C4W_A       193 LGRGGFGEVFACQMkatgKLYACKKLNKKRLKKrkgyQGAMVEKKILAKVhSRFIVSLAYAFETktDLCLVMTIMNGGDI 272 cattle
NP_001029353 197 LGKGGFGEVSACQMratgKLYACKKLNKKRLKKrkgyEGAMVEKRILARVhSRFIVSLAYAFQTktELCLVMTIMNGGDL 276 zebrafish
AAH94133     188 LGKGGFGEVSATQMratgKMYACKKLSKKRLKKrkgfEGAMVEKRILAKVhSRFIVSLAYAFQTktDVCLVMTLMNGGDL 267 African clawed ...
AAC08428     226 LGKGGFGKVCACQRratgKMYANKKLNKKRLKKrqgyEAAMVEKRILARVhSRFIVSLACAFQTktDLCLVMTLMNGGDL 305 chicken
Q15835       196 LGKGGFGEVSACQMkatgKLYACKKLNKKRLKKrkgyQGAMVEKKILMKVhSRFIVSLAYAFETkaDLCLVMTIMNGGDI 275 human
Feature 1        #                                        # # ## #         ##  #             ####
3C4X_A       273 RYHIYNvdednpgFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDddGNVRISDLGLAVELKAGQTKTKGYAGT 352 cattle
3C4W_A       273 RYHIYNvdednpgFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDddGNVRISDLGLAVELKAGQTKTKGYAGT 352 cattle
NP_001029353 277 RYHIYNvdennpgFSEPRACYYAAQIIQGLEHLHQKKIIYRDLKPENVLLDneGNVRISDLGLAVELADGQEKTKGYAGT 356 zebrafish
AAH94133     268 RFHIYNldeenpgLDEHRACFYTAQIISGLEHLHQNRIIYRDLKPENVLLDndGNVRISDLGLAVELKEKKSKTKGYAGT 347 African clawed ...
AAC08428     306 RYHVYNvdeenpgFPEPRAVFYTAQILLGLEHLHQHRIVYRDLKPENVLLDdaGHVRLSDMGLAVELKDGQNKTRGYAGT 385 chicken
Q15835       276 RYHIYNvneenpgFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDndGNVRISDLGLAVELLDGQSKTKGYAGT 355 human
Feature 1        ##                          #     #  #                                          
3C4X_A       353 PGFMAPELLLGeeydFSVDYFALGVTLYEMIAARGPFRARgekveNKELKQRVLeQAVTYPDKfsPASKDFCEALLQKdP 432 cattle
3C4W_A       353 PGFMAPELLLGeeydFSVDYFALGVTLYEMIAARGPFRARgekveNKELKQRVLeQAVTYPDKfsPASKDFCEALLQKdP 432 cattle
NP_001029353 357 PGFMAPELLKGeeydYSVDYFTLGVTLYEFIAAKGPFRTRgekveNKEVKKRILnDPVTYSEKfsENAKSICEGLLAKeV 436 zebrafish
AAH94133     348 PGFMAPELLQGeeydYSVDYFSLGVTLYEMIAARGPFRCRgekveNKELKNRILnDSVTYTVKfsLDCKSICEALLDKdP 427 African clawed ...
AAC08428     386 PGFMAPEVLRDeeydMAVDYFTLGVTLYEMLDAKGPFRRRgekveKKEVTRRTLhDSVSYSERfsAASRSLCEGLLAKdP 465 chicken
Q15835       356 PGFMAPELLQGeeydFSVDYFALGVTLYEMIAARGPFRARgekveNKELKHRIIsEPVKYPDKfsQASKDFCEALLEKdP 435 human
Feature 1                                                
3C4X_A       433 EKRLGFrdgsCDGLRTHPLFRDISWrqLEAGMLTPPFVPD 472 cattle
3C4W_A       433 EKRLGFrdgsCDGLRTHPLFRDISWrqLEAGMLTPPFVPD 472 cattle
NP_001029353 437 DKRLGFkngtCDEIRTHPFFSQLNWrkLDAGILPPPFVPD 476 zebrafish
AAH94133     428 KKRMGFkdgnCNQIRAHLFFRGINWrkLEAGILPAPFAPD 467 African clawed frog
AAC08428     466 QKRLGFrdgnCAMLRSQPVFSALHWg-SWSGPPPPPFVPD 504 chicken
Q15835       436 EKRLGFrdetCDKLRAHPLFKDLNWrqLEAGMLMPPFIPD 475 human

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