2ACX


Conserved Protein Domain Family
STKc_GRK4_like

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cd05605: STKc_GRK4_like (this model, PSSM-Id:173696 is obsolete and has been replaced by 270756)
Click on image for an interactive view with Cn3D
Catalytic domain of G protein-coupled Receptor Kinase 4-like Protein Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), G protein-coupled Receptor Kinase (GRK) subfamily, GRK4-like group, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. There are seven types of GRKs, named GRK1 to GRK7. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. GRKs in this group contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2.
Statistics
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Aligned: 5 rows
Threshold Bit Score: 508.214
Threshold Setting Gi: 1353144
Created: 18-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #####   #            # #                               #               ##
2ACX_B       185 TFRQYRVLGKGGFGEVCACQVratgKMYACKKLEKKRIkkrKGEAMALNEKQILEKVnSRFVVSLAYAYETkdALCLVLT 264 human
Q09537       202 TFRLYRVLGKGGFGEVCACQVrasgKMYALKKLEKKRVkkrHAETLSLNEKQILQRInSPFVVSLAYAYETkdALCLVLT 281 nematode
Q8VEB1       185 TFRQYRVLGKGGFGEVCACQVratgKMYACKRLEKKRIkkrKGESMALNEKQILEKVnSQFVVNLAYAYETkdALCLVLT 264 house mouse
NP_001004056 154 TFRHYRVLGKGGFGEVCACQVratgKMYACKKLQKKRIkkrKGEAMALNEKRILEKVqSRFVVSLAYAYETkdALCLVLT 233 human
XP_001639641 175 TFRHYRVLGKGGFGEVCACQSkisgKMYAMKKLEKKRIkrrKGEAMALNEKTLLEKIdSIFVVSLAYAYETkdALCMVLT 254 starlet sea ane...
Feature 1         #   # #                                      # # ## #         ##  #            
2ACX_B       265 LMnGGDLKFHIYHmgqaGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDdhGHIRISDLGLAVHVPEGQTIKG 344 human
Q09537       282 LMnGGDLKFHLYNlmpgGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDdfGHVRISDLGLAVEIKDNEPIKG 361 nematode
Q8VEB1       265 IMnGGDLKFHIYNmgnpGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDdyGHIRISDLGLAVKIPEGDLIRG 344 house mouse
NP_001004056 234 IMnGGDLKFHIYNlgnpGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDdrGHIRISDLGLATEIPEGQRVRG 313 human
XP_001639641 255 LMnGGDLKFHVHNmgnpGFEEERAVFYAAQVTLGLIHLHSQRIVYRDLKPENLLLDdyGHVRISDLGLAVQIRNGETIRG 334 starlet sea ane...
Feature 1        ######                          #     #  #                                      
2ACX_B       345 RVGTVGYMAPEVVKNErytFSPDWWALGCLLYEMIAGQSPFQQRkkkiKREEVERLVKEVPEEYSERfsPQARSLCSQLL 424 human
Q09537       362 RVGTVGYMAPEIVKNErysYGVDWWGVGCLIYEMIEGKAPFRQRkekvKREEVERRVREDQEKYSEKfsEAARTLCRGLL 441 nematode
Q8VEB1       345 RVGTVGYMAPEVLNNQrygLSPDYWGLGCLIYEMIEGQSPFRGRkekvKREEVDRRVLETEEVYSSKfsEEAKSICNMLL 424 house mouse
NP_001004056 314 RVGTVGYMAPEVVNNEkytFSPDWWGLGCLIYEMIQGHSPFKKYkekvKWEEVDQRIKNDTEEYSEKfsEDAKSICRMLL 393 human
XP_001639641 335 RVGTIGYMAPEVVKNErytFSPDWWGLGCLIYEMIQGKSPFRARkekvKREEVERRVKEDQETYSDKftSYARSICVQTL 414 starlet sea ane...
Feature 1                                                                   
2ACX_B       425 CKdPAERLGCRg-----gSAREVKEHPLFKkln---------fkrLGAGMLEPPFKPDP 469 human
Q09537       442 HKePGFRLGCRrvgrpedGAEEIRAHPFFNtadtvtgrepvpwkkMEAGKVTPPFCPDP 500 nematode
Q8VEB1       425 TKdSKQRLGCQe-----eGAAEVKRHPFFRnmn---------fkrLEAGMLDPPFVPDP 469 house mouse
NP_001004056 394 TKnPSKRLGCRg-----eGAAGVKQHPVFKdin---------frrLEANMLEPPFCPDP 438 human
XP_001639641 415 QKdPTNRLGCK-------EDEDIRNHPFFRsvl---------wkqLEAGLIPPPFVPDP 457 starlet sea anemone

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