Conserved Protein Domain Family
STKc_SGK3

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cd05604: STKc_SGK3 (this model, PSSM-Id:173695 is obsolete and has been replaced by 270755)
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3
Serine/Threonine Kinases (STKs), Serum- and Glucocorticoid-induced Kinase (SGK) subfamily, SGK3 isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). SGK3 is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling.
Statistics
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PSSM-Id: 173695
View PSSM: cd05604
Aligned: 3 rows
Threshold Bit Score: 673.257
Threshold Setting Gi: 71896433
Created: 18-Oct-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The ATP binding site is based on the binding of AMP-PNP to SGK1. The substrate binding site is based on the binding of peptide substrates to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ## #### #            # #                                #                # #  
gi 119367372 166 KVIGKGSFGKVLLAKRKldgKFYAVKVLQKKIVLNRKeqKHIMAERNVLLKNvkHPFLVGLHYSFQTteKLYFVLDFVnG 245
gi 134026306 156 KVIGKGSFGKVLLAKRKrdgKCYAIKVLQKKVILNRReqKHIMAERNVLLKNvkHPFLVGLHYSFQTtdKLYFVLDFVnG 235
gi 71896433  160 KVIGKGSFGKVLLAKRKldgKYYAVKVLQKKIVLNRKeqKHIMAERNVLLKNvkHPFLVGLHYSFQTteKLYFVLDFVnG 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #                                    # # ## #         ##  #             #####
gi 119367372 246 GELFFHLQRersFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDsmGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
gi 134026306 236 GELFFHLQKertFPEPRAKFYIAEMASALGYLHSLNIVYRDLKPENILLDsqGHIVLTDFGLCKEGISQADTTTTFCGTP 315
gi 71896433  240 GELFFHLQRersFPEHRARFYAAEIASALGYLHSINIVYRDLKPENILLDslGHVVLTDFGLCKEGIASSDTTATFCGTP 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                          #     #  #                                           
gi 119367372 326 EYLAPEVIRKqpyDRTVDWWCLGAVLYEMLYGLPPFYCRdvAEMYDNILHKPLNLRPGvsLTAWSILEELLEknRQNRLG 405
gi 134026306 316 EYLAPEVLRKqpyDNTVDWWCLGSVLYEMLYGLPPFYSRdtHEMYDNILHKELVMRPGasTAAWSILQTLLEkdHTRRLG 395
gi 71896433  320 EYLAPEVIKKqpyDNTVDWWCLGAVLYEMLYGLPPFYCRdvAEMYENILHKPLVLRPGisLTAWSILEELLEkdRQSRLG 399
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 119367372 406 akedFLEIQNHPFFESLSWTDLVQKKIPPPFNPnvagpddirNFDAVFTEETVPYSVCVSSdysivnasvleaDDAFVGF 485
gi 134026306 396 yrddFNEVKEHEFFSSINWYDLEQKKLPPPFNPsvesqydisNFDPEFTEETVPNSVCFSSgpsivnasvmeaDDAFLGF 475
gi 71896433  400 akedFLEIQKHPFFESLSWTDLLQKKIPPPFNPnvvgpddigNFDAVFTEEMVPYSVCISSdysivnasvleaDDAFVGF 479

                 ....*
Feature 1             
gi 119367372 486 SYAPP 490
gi 134026306 476 SYAPP 480
gi 71896433  480 SYAPP 484

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