Conserved Protein Domain Family
STKc_LATS

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cd05598: STKc_LATS (this model, PSSM-Id:173689 is obsolete and has been replaced by 270749)
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor
Serine/Threonine Kinases (STKs), Large Tumor Suppressor (LATS) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation.
Statistics
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PSSM-Id: 173689
View PSSM: cd05598
Aligned: 6 rows
Threshold Bit Score: 676.527
Threshold Setting Gi: 17509105
Created: 24-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #####   #             # #                               #               
gi 52783106   703 SMFVKIKTLGIGAFGEVCLARKVDt-kALYATKTLRKKDVLlrNQVAHVKAERDILAEAdNEWVVRLYYSFQDkdNLYFV 781
gi 903942     711 SMFVKLKPIGVGAFGEVTLVSKIDtsnHLYAMKTLRKADVLkrNQVAHVKAERDILAEAdNNWVVKLYYSFQDkdNLYFV 790
gi 17509105   500 SHFTVISHIGVGAFGKVSLVRKNDt-rKVYAMKSLEKADVImkQQAAHVKAERDILAEAdSPWIVRLFFSFQDdaCLYFI 578
gi 115742081  779 SMFKKIKTLGIGAFGEVALARKVDt-nALYAVKKLRKLDVIqrNQAGHVKAERDILAEAdNEWVVKLYYSFQDkdNLYFV 857
gi 156369669   36 SMFEKIRTIGIGAFGEVWLVRKTDt-sMLYAMKILRKSEVFrrNQAAHVKAERDILAEAdNEWVVKLYYSFQDqeNLYFV 114
gi 118085059  705 SMFVKIKTLGIGAFGEVCLACKVDt-hALYAMKTLRKKDVLnrNQVAHVKAERDILAEAdNEWVVKLYYSFQDkeNLYFV 783
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ## #   # #                                    # # ## #         ##  #            
gi 52783106   782 MDYIpGGDMMSLLIRmgIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHDSKY 861
gi 903942     791 MDYIpGGDLMSLLIKlgIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHNSKY 870
gi 17509105   579 MEYVpGGDMMTLLIQkgIFEEDLARFYIAELACAIEYVHNVGFIHRDLKPDNILIDqhGHIKLTDFGLCTGLRWTHDRRY 658
gi 115742081  858 MDYIpGGDLMSLLIRleIFEEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDrdGHIKLTDFGLCTGFRWTHDSKY 937
gi 156369669  115 MDYVpGGDLMSLLIKfgIFPEDYAKFYIAELVLAIDSVHRMGFVHRDIKPDNILIDkdGHIKLTDFGLCTGFRWTHDSKY 194
gi 118085059  784 MDYIpGGDMMSLLIRmeVFPERLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDldGHIKLTDFGLCTGFRWTHNSKY 863
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     ######              
gi 52783106   862 Yqs-gDHPRQDSMDfsnewgdpsscrc----------gdrlkplerraaRQHQR-CLAHSLVGTPNYIAPEVLLRtGYTQ 929
gi 903942     871 YqengNHSRQDSMEpweeysengp---------------kptvlerrrmRDHQR-VLAHSLVGTPNYIAPEVLERsGYTQ 934
gi 17509105   659 YgpenDHHRVDSFSlppevaaid------------------ksvkvlnvRQQTRrITAHSLVGTGNYMAPEVIAKtGHNQ 720
gi 115742081  938 Yqk-sGHARQDSMEpfdtlssldkr--------------plktlerrrkRQQER-CKAHSLVGTPNYIAPEVLTRtGYTQ 1001
gi 156369669  195 Yek-gQHMRQDSMEpderaweemratchcgdisidkpysemkplerrhfRKHMR-CQAHSLVGTPNYIAPEVLLRiGYRQ 272
gi 118085059  864 Yqk-gSHIRQDSMEpsdlwddvsncrc----------gdrlktleqrakKQHQR-CLAHSLVGTPNYIAPEVLLRkGYTQ 931
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #     #  #                                                          
gi 52783106   930 LCDWWSVGVILFEMLVGQPPFLAQtPLETQMKVINWQTSLHIPPQaklSPEASDLIIKLCRGPEDRLGkn------gADE 1003
gi 903942     935 LCDYWSVGVILYEMLVGQPPFLANsPLETQQKVINWEKTLHIPPQaelSREATDLIRRLCASADKRLGk-------sVDE 1007
gi 17509105   721 SCDWWSTGVILYEMVFGRVPFHDDtPGGTQHRIKNWRNFLDFTYCgnlSKECLMMIQQLICDASSRLGshgkdvaerTAQ 800
gi 115742081 1002 LCDWWSVGVILYEMLVGQPPFHADsPAETQWKVINWKQCLHIPSQaklSRDASDFILRLCTGPEERLGkn------gVLD 1075
gi 156369669  273 SCDWWSVGVILYEMLVGQPPFLAPtPAETQLKIINWETELRIPHQarlSREAKDLILRLCTNADMRLGsn------gASE 346
gi 118085059  932 LCDWWSVGVILFEMLVGQPPFLAPtPTETQLKVINWESTLHIPSQiklSPEAADLITKLCCAAEDRLGrn------gADD 1005
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 52783106  1004 IKAHPFFKTIDFSSdl-rQQSASYIPKITHPTDTSNFDpvdpdklwsddneeenvndtlngwykngkhpEHAFYEFTFRR 1082
gi 903942    1008 VKSHDFFKGIDFADm--rKQKAPYIPEIKHPTDTSNFDpvdpeklrsndst-----mssgddvdqndrtFHGFFEFTFRR 1080
gi 17509105   801 VKNHPWFRGIDWVNlrklRADYIYIPRVTHDEDTSNFEtfqdndrad--------------kpnvrglhNPAFYEFTYRH 866
gi 115742081 1076 IKSHPFFQTIDLDSni-rKMKAPYIPTVRHPTDTSNFDpvspnklgsdsstds-wdsnpneeenhrqqtDHAFFEFTFRR 1153
gi 156369669  347 IKAHPFFACVDWAYla-kRVQAPYTPVIRFPTDTANFDpvdperlrtsdsged--spdrlvpdrsnhrpEHAFFEFTFRR 423
gi 118085059 1006 IKAHSFFHSMDFSTdi-rRQPAPYVPKISHPMDTSNFDpveeespwndasgds-trtwdplassnskhtEHAFYEFTFRR 1083

                  ..
Feature 1           
gi 52783106  1083 FF 1084
gi 903942    1081 FF 1082
gi 17509105   867 FF 868
gi 115742081 1154 FF 1155
gi 156369669  424 FF 425
gi 118085059 1084 FF 1085

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