Conserved Protein Domain Family
STKc_LATS

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cd05598: STKc_LATS (this model, PSSM-Id:173689 is obsolete and has been replaced by 270749)
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor
Serine/Threonine Kinases (STKs), Large Tumor Suppressor (LATS) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation.
Statistics
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PSSM-Id: 173689
View PSSM: cd05598
Aligned: 6 rows
Threshold Bit Score: 676.527
Threshold Setting Gi: 17509105
Created: 24-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #####   #             # #                               #               
O95835        703 SMFVKIKTLGIGAFGEVCLARKVDt-kALYATKTLRKKDVLlrNQVAHVKAERDILAEAdNEWVVRLYYSFQDkdNLYFV 781  human
AAA70336      711 SMFVKLKPIGVGAFGEVTLVSKIDtsnHLYAMKTLRKADVLkrNQVAHVKAERDILAEAdNNWVVKLYYSFQDkdNLYFV 790  fruit fly
NP_492699     500 SHFTVISHIGVGAFGKVSLVRKNDt-rKVYAMKSLEKADVImkQQAAHVKAERDILAEAdSPWIVRLFFSFQDdaCLYFI 578  nematode
XP_795100     779 SMFKKIKTLGIGAFGEVALARKVDt-nALYAVKKLRKLDVIqrNQAGHVKAERDILAEAdNEWVVKLYYSFQDkdNLYFV 857  purple urchin
XP_001628097   36 SMFEKIRTIGIGAFGEVWLVRKTDt-sMLYAMKILRKSEVFrrNQAAHVKAERDILAEAdNEWVVKLYYSFQDqeNLYFV 114  starlet sea a...
XP_417143     705 SMFVKIKTLGIGAFGEVCLACKVDt-hALYAMKTLRKKDVLnrNQVAHVKAERDILAEAdNEWVVKLYYSFQDkeNLYFV 783  chicken
Feature 1         ## #   # #                                    # # ## #         ##  #            
O95835        782 MDYIpGGDMMSLLIRmgIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHDSKY 861  human
AAA70336      791 MDYIpGGDLMSLLIKlgIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDrdGHIKLTDFGLCTGFRWTHNSKY 870  fruit fly
NP_492699     579 MEYVpGGDMMTLLIQkgIFEEDLARFYIAELACAIEYVHNVGFIHRDLKPDNILIDqhGHIKLTDFGLCTGLRWTHDRRY 658  nematode
XP_795100     858 MDYIpGGDLMSLLIRleIFEEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDrdGHIKLTDFGLCTGFRWTHDSKY 937  purple urchin
XP_001628097  115 MDYVpGGDLMSLLIKfgIFPEDYAKFYIAELVLAIDSVHRMGFVHRDIKPDNILIDkdGHIKLTDFGLCTGFRWTHDSKY 194  starlet sea a...
XP_417143     784 MDYIpGGDMMSLLIRmeVFPERLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDldGHIKLTDFGLCTGFRWTHNSKY 863  chicken
Feature 1                                                                     ######              
O95835        862 Yqs-gDHPRQDSMDfsnewgdpsscrc----------gdrlkplerraaRQHQR-CLAHSLVGTPNYIAPEVLLRtGYTQ 929  human
AAA70336      871 YqengNHSRQDSMEpweeysengp---------------kptvlerrrmRDHQR-VLAHSLVGTPNYIAPEVLERsGYTQ 934  fruit fly
NP_492699     659 YgpenDHHRVDSFSlppevaaid------------------ksvkvlnvRQQTRrITAHSLVGTGNYMAPEVIAKtGHNQ 720  nematode
XP_795100     938 Yqk-sGHARQDSMEpfdtlssldkr--------------plktlerrrkRQQER-CKAHSLVGTPNYIAPEVLTRtGYTQ 1001 purple urchin
XP_001628097  195 Yek-gQHMRQDSMEpderaweemratchcgdisidkpysemkplerrhfRKHMR-CQAHSLVGTPNYIAPEVLLRiGYRQ 272  starlet sea a...
XP_417143     864 Yqk-gSHIRQDSMEpsdlwddvsncrc----------gdrlktleqrakKQHQR-CLAHSLVGTPNYIAPEVLLRkGYTQ 931  chicken
Feature 1                     #     #  #                                                          
O95835        930 LCDWWSVGVILFEMLVGQPPFLAQtPLETQMKVINWQTSLHIPPQaklSPEASDLIIKLCRGPEDRLGkn------gADE 1003 human
AAA70336      935 LCDYWSVGVILYEMLVGQPPFLANsPLETQQKVINWEKTLHIPPQaelSREATDLIRRLCASADKRLGk-------sVDE 1007 fruit fly
NP_492699     721 SCDWWSTGVILYEMVFGRVPFHDDtPGGTQHRIKNWRNFLDFTYCgnlSKECLMMIQQLICDASSRLGshgkdvaerTAQ 800  nematode
XP_795100    1002 LCDWWSVGVILYEMLVGQPPFHADsPAETQWKVINWKQCLHIPSQaklSRDASDFILRLCTGPEERLGkn------gVLD 1075 purple urchin
XP_001628097  273 SCDWWSVGVILYEMLVGQPPFLAPtPAETQLKIINWETELRIPHQarlSREAKDLILRLCTNADMRLGsn------gASE 346  starlet sea a...
XP_417143     932 LCDWWSVGVILFEMLVGQPPFLAPtPTETQLKVINWESTLHIPSQiklSPEAADLITKLCCAAEDRLGrn------gADD 1005 chicken
Feature 1                                                                                         
O95835       1004 IKAHPFFKTIDFSSdl-rQQSASYIPKITHPTDTSNFDpvdpdklwsddneeenvndtlngwykngkhpEHAFYEFTFRR 1082 human
AAA70336     1008 VKSHDFFKGIDFADm--rKQKAPYIPEIKHPTDTSNFDpvdpeklrsndst-----mssgddvdqndrtFHGFFEFTFRR 1080 fruit fly
NP_492699     801 VKNHPWFRGIDWVNlrklRADYIYIPRVTHDEDTSNFEtfqdndrad--------------kpnvrglhNPAFYEFTYRH 866  nematode
XP_795100    1076 IKSHPFFQTIDLDSni-rKMKAPYIPTVRHPTDTSNFDpvspnklgsdsstds-wdsnpneeenhrqqtDHAFFEFTFRR 1153 purple urchin
XP_001628097  347 IKAHPFFACVDWAYla-kRVQAPYTPVIRFPTDTANFDpvdperlrtsdsged--spdrlvpdrsnhrpEHAFFEFTFRR 423  starlet sea a...
XP_417143    1006 IKAHSFFHSMDFSTdi-rRQPAPYVPKISHPMDTSNFDpveeespwndasgds-trtwdplassnskhtEHAFYEFTFRR 1083 chicken
Feature 1           
O95835       1083 FF 1084 human
AAA70336     1081 FF 1082 fruit fly
NP_492699     867 FF 868  nematode
XP_795100    1154 FF 1155 purple urchin
XP_001628097  424 FF 425  starlet sea anemone
XP_417143    1084 FF 1085 chicken

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