1XJD


Conserved Protein Domain Family
STKc_nPKC_theta_delta

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cd05592: STKc_nPKC_theta_delta (this model, PSSM-Id:173683 is obsolete and has been replaced by 270744)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinases, Novel Protein Kinase C theta and delta
Serine/Threonine Kinases (STKs), Novel Protein Kinase C (nPKC), theta and delta-like isoforms, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types.
Statistics
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PSSM-Id: 173683
Aligned: 5 rows
Threshold Bit Score: 604.864
Created: 4-Apr-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #####   #            # #                                #               ## #  
1XJD_A        23 KMLGKGSFGKVFLAEFkktnQFFAIKALKKDvvlmdDDVECTMVEKRVLSLAweHPFLTHMFCTFQTkeNLFFVMEYLnG 102 human
P34722       379 KVLGKGSFGKVMLVELkgknEFYAMKCLKKDviledDDTECTYIERRVLILAsqCPFLCQLFCSFQTneYLFFVMEYLnG 458 nematode
XP_787505    265 KVLGKGSFGKVMLAEQkgtkKYFAIKALKKEvvledDDIECTMVERHVLGLAwaHPFLTHLYCTFQSkeHLFFVMEYLnG 344 purple urchin
NP_511171    347 AVLGKGSFGKVLLAELrdttYYYAIKCLKKDvvledDDVDSTLIERKVLALGtkHPYLCHLFCTFQTesHLFFVMEYLnG 426 fruit fly
NP_001006133 361 KVLGKGSFGKVLLAELkgknEFFAIKALKKDvvlidDDVECTMVEKRVLALAweNPFLTHLYCTFQTkdHLFFVMEFLnG 440 chicken
Feature 1         # #                                                   # # ## #         ##  #   
1XJD_A       103 GDLMYHIQSchkFDLSRATFYAAEIILGLQFLHS---------------KGIVYRDLKLDNILLDkdGHIKIADFGMCKE 167 human
P34722       459 GDLMHHIQQikkFDEARTRFYACEIVVALQFLHT---------------NNIIYRDLKLDNVLLDcdGHIKLADFGMAKT 523 nematode
XP_787505    345 GDLMFHIQSslrFEEKRARFYAAEIICGLQFLHK---------------RGIIYRDLKLDNVLLDrdGHIKIADFGMCKQ 409 purple urchin
NP_511171    427 GDLMFHIQEsgrFSEERARFYGAEIISGLKFLHK---------------KGIIYRDLKLDNVLLDyeGHVRIADFGMCKL 491 fruit fly
NP_001006133 441 GDLMFHIQDkgrFDLYRATFYGAEILCGLQFLHSkgiiyrkftsitsepNWSSFRDLKLDNVMLDkeGRIKIADFGMCKE 520 chicken
Feature 1                   ######                          #     #  #                           
1XJD_A       168 NMLGD-AKTNXFCGTPDYIAPEILLGqkyNHSVDWWSFGVLLYEMLIGQSPFHGQdeEELFHSIRMDNPFYPRWleKEAK 246 human
P34722       524 EMNREnGMASTFCGTPDYISPEIIKGqlyNEAVDFWSFGVLMYEMLVGQSPFHGEgeDELFDSILNERPYFPKTisKEAA 603 nematode
XP_787505    410 NITGE-TKASTFCGTPDYIAPEILKGqkyAASVDWWSFGVLLYEMLIGQSPFHGEdeDQLFDCILHDAPHFPRWltKDAH 488 purple urchin
NP_511171    492 QIYLD-KTADSFCGTPDYMAPEIIKGekyNQNVDWWSFGVLLYEMLIGQSPFSGCdeDELFWSICNEIPWFPVYisAEAT 570 fruit fly
NP_001006133 521 NVVGE-NKASTFCGTPDYIAPEILQGlkyTFSVDWWSFGVLLYEMLIGQSPFHGDdeDELFESIRVDTPHYPRWitKESK 599 chicken
Feature 1                                                                                        
1XJD_A       247 DLLVKLFVrePEKRLGv----rGDIRQHPLFREINWEELERKEIDPPFRPkvkspfDCSNFDKEFLNEKPRLSFadra-l 321 human
P34722       604 KCLSALFDrnPNTRLGmpecpdGPIRQHCFFRGVDWKRFENRQVPPPFKPniksnsDASNFDDDFTNEKAALTPvhdknl 683 nematode
XP_787505    489 SCLIQLLErtPEVRLGv----kGDVRAHQFFKSIDFEKLERRELPPPFKPkiksdgDASNFDPEFTMEKVALSPtdts-m 563 purple urchin
NP_511171    571 GILKGLLEkdYTKRIGsqyspaGDIADHIFFRPIDWGLLEKRQIEPPFKPqvkhplDTQYFDRVFTRERVRLTPidke-i 649 fruit fly
NP_001006133 600 DLLEKLFErdPTRRLGv----tGNIRDHPFFKTINWTTLEKREIDPPFKPkvksasDYNNFDREFLNEKPKLSYsdkn-l 674 chicken
Feature 1                         
1XJD_A       322 inSMDQNMFRNFXFMNP 338 human
P34722       684 laSIDPEAFLNFSYTNP 700 nematode
XP_787505    564 lsSINQRQFRGFSFTNP 580 purple urchin
NP_511171    650 laSMDQKQFHGFTYTNP 666 fruit fly
NP_001006133 675 idSMDQSAFAGFSFTNP 691 chicken

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