Conserved Protein Domain Family
STKc_nPKC_epsilon

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cd05591: STKc_nPKC_epsilon (this model, PSSM-Id:173682 is obsolete and has been replaced by 270743)
Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C epsilon
Serine/Threonine Kinases (STKs), Novel Protein Kinase C (nPKC), epsilon isoform, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility.
Statistics
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Aligned: 9 rows
Threshold Bit Score: 649.216
Threshold Setting Gi: 156368406
Created: 4-Apr-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #####   #            # #                                #               ## #  
AAI09034     412 KVLGKGSFGKVMLAELkgkdEVYAVKVLKKDvilqdDDVDCTMTEKRILALArkHPYLTQLYCCFQTkdRLFFVMEYVnG 491 human
125547       307 KVLGKGSFGKVMLAEKkgtdEIYAIKVLKKDaiiqdDDVDCTMTEKRILALAanHPFLTALHSCFQTpdRLFFVMEYVnG 386 fruit fly
AAM90321     419 KVLGKGSFGKVMLGERkgtdEVYAIKVLRKDvilqdDDVDCTMTEKRILTLAakHPFLTALCCSFQTedRLFFVMEYVnG 498 Atlantic horses...
Q16975       407 KVLGKGSFGKVMLAEKkgtdEVYAIKVLKKDviiqdDDVECTMTEKRILALSakHPFLTALHSSFQTkeRLFFVMEYVnG 486 California sea ...
CAG00344     432 KVLGKGSFGKVMLAELkgsdEVYAVKVLKKDvilqdDDVDCTLTEKRILALArkHPYLTQLFCCFQTkdRLFFVMEYVnG 511 Tetraodon nigro...
XP_419464    418 KVLGKGSFGKVMLAELkgkdEVYAVKVLKKDvilqdDDVDCTMTEKRILALArkHPYLTQLYCCFQTkdRLFFVMEYVnG 497 chicken
NP_506014    382 KVLGKGSFGKVMLAERkgtdEVYAIKILKKDvivqdDDVECTMCEKRILSLAakHPFLTALHSSFQTsdRLFFVMEYVnG 461 nematode
AAI24569     417 KVLGKGSFGKVMLAELkgrdEVYAVKVLKKDvilqdDDVDCTMTEKRILALArrHPYLTQLYCCFQTkdRLFFVMEYVnG 496 western clawed ...
XP_001627685 387 KVLGKGSFGKVLLAERkgtdEVYAIKILKKEsvlqdDDVECTMIERRVLALSagHPFLTSLHSSFQTveRLFFVMEYVnG 466 starlet sea ane...
Feature 1         # #                                    # # ## #         ##  #             #####
AAI09034     492 GDLMFQIQRsrkFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDaeGHCKLADFGMCKEGILNGVTTTTFCGTP 571 human
125547       387 GDLMFQIQKarrFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDqeGHCKLADFGMCKEGIMNGMLTTTFCGTP 466 fruit fly
AAM90321     499 GDLMFQIQKarkFDEARARFYAAEVTLALMFLHRHGVIYRDLKLDNILLDseGHCKIADFGMCKEGIAGGATTTTFCGTP 578 Atlantic horses...
Q16975       487 GDLMFQIQRarkFDEPRARFYAAEVTLALMFLHRHGIIYRDLKLDNILLDaeGHCKIADFGMCKEGMTENKLTQTFCGTP 566 California sea ...
CAG00344     512 GDLMFQIQRsrkFDEARSRFYAAEVTSALMFLHRHGVIYRDLKLDNILLDadGHCKLADFGMCKEGILNGITTTTFCGTP 591 Tetraodon nigro...
XP_419464    498 GDLMFQIQRsrkFDEPRSRFYAAEVTSALMFLHQHGVIYRYLDSGNILLDaeGHCKLAAFGMCKEGILNGVTTTTFCGTP 577 chicken
NP_506014    462 GDLMFQIQRarkFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDaeGHCRLADFGMCKEGINKDNLTSTFCGTP 541 nematode
AAI24569     497 GDLMFQIQRsrkFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDaeGHCKLADFGMCKEGILNGVTTTTFCGTP 576 western clawed ...
XP_001627685 467 GDLMFQIQKsrkFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDadGHIKLADFGMCKENMAPGKTTTTFCGTP 546 starlet sea ane...
Feature 1        #                          #     #  #                                           
AAI09034     572 DYIAPEILQEleyGPSVDWWALGVLMYEMMAGQPPFEADneDDLFESILHDDVLYPVWlsKEAVSILKAFMTknPHKRLG 651 human
125547       467 DYIAPEILKEqeyGASVDWWALGVLMYEMMAGQPPFEADneDELFDSIMHDDVLYPVWlsREAVSILKGFLTknPEQRLG 546 fruit fly
AAM90321     579 DYIAPEILQEleyGPSVDWWALGVLMYEMMAGQPPFEADneDDLFESILHEDVVYPVWlsKEAVSVLKGFMTknPAKRLG 658 Atlantic horses...
Q16975       567 DYIAPEILQElkyDASVDWWALGVLMYEMMAGQPPFEADneDDLFESILHDDVLYPVWlsKEAVSILKGFMTknPAKRLG 646 California sea ...
CAG00344     592 DYIAPEILQEldyGPSVDWWALGVLMYEMMAGQPPFEADneDDLFESILHDDVLYPVWlsKEAVSILKAFMTksPNKRLG 671 Tetraodon nigro...
XP_419464    578 DYIAPEILQEleyGPSVDWWALGVLMYEMMAGQPPFEADneDDLFESILHDDVLYPVWlsKEAVSILKAFMTknPNKRLG 657 chicken
NP_506014    542 DYIAPEILQEmeyGVSVDWWALGVLMYEMMAGQPPFEADneDDLFEAILNDDVLYPVWlsKEAVNILKAFMTknAGKRLG 621 nematode
AAI24569     577 DYIAPEILQEleyGPSVDWWALGVLMYEMMAGQPPFEADneDDLFESILHDDVLYPVWlsKEAVSILKAFMTknPNKRLG 656 western clawed ...
XP_001627685 547 DYIAPEILQEqpyGFSVDWWALGVLMYEMMAGQPPFEAEneEDLFESILHDDVLYPVWlsREAVSILKGFMTknYLKRLG 626 starlet sea ane...
Feature 1                                                                                        
AAI09034     652 CvasqngeDAIKQHPFF-KEIDWVLLEqKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLvdeaivkqINQEEFKGFSY 730 human
125547       547 Ctg---deNEIRKHPFF-AKLDWKELEkRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPignevvrcINQDEFAGFSF 622 fruit fly
AAM90321     659 CvpsqgleQAILNHIFF-KEIDWDALEsRKVKPPFRPKIKTKRDVNNFDQDFTKEDPVLTQvnpdvirtINQEEFRGFSV 737 Atlantic horses...
Q16975       647 CvttqgceKAILVHPFFhEKIDWEALEqRKVKPPFKPKIKNKTDANNFDRDFTSEDPVLTPvdpaviktINQEEFRGFSF 726 California sea ...
CAG00344     672 CvvaqgleEAIKLHPFF-REIDWTLLEqRKIRPPFKPRIKTKRDVNNFDQDFTREEPVLTPvdnsiikqINQDEFKGFSY 750 Tetraodon nigro...
XP_419464    658 CvasqngeDAIKQHPFF-KEIDWVLLEqRKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLvdetiikqINQEEFKGFSY 736 chicken
NP_506014    622 CvvsqggeDAIRAHPFF-REIDWDALEsRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPsdpavvraINQDEFRGFSF 700 nematode
AAI24569     657 CvaaqgleEAIKQHPFF-KEIDWVLLEqRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLvdeaivkqINQEEFKGFSY 735 western clawed ...
XP_001627685 627 Ctpt-steSSIREHAFF-RLINFEKLEaRQINPPFKPKIRSRTDVGNFDTDFTKEEPKLTPtdrnvivnIDQREFRGFSF 704 starlet sea ane...
Feature 1          
AAI09034     731 FG 732 human
125547       623 VN 624 fruit fly
AAM90321     738 VN 739 Atlantic horseshoe crab
Q16975       727 AN 728 California sea hare
CAG00344     751 FG 752 Tetraodon nigroviridis
XP_419464    737 FG 738 chicken
NP_506014    701 IN 702 nematode
AAI24569     736 FG 737 western clawed frog
XP_001627685 705 VN 706 starlet sea anemone

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