Conserved Protein Domain Family
STKc_PKN

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cd05589: STKc_PKN (this model, PSSM-Id:173680 is obsolete and has been replaced by 270741)
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase N
Serine/Threonine Kinases (STKs), Protein Kinase N (PKN) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis.
Statistics
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PSSM-Id: 173680
Aligned: 15 rows
Threshold Bit Score: 594.737
Created: 23-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #####   #            # #                                  #               
Q16513     657 FRCCAVLGRGHFGKVLLAEYkntnEMFAIKALKKGDivarDEVDSLMCEKRIFETVnsvRHPFLVNLFACFQTkeHVCFV 736  human
NP_788290  863 FRLLSVLGRGHFGKVILSQLrsnnQYYAIKALKKGDiiarDEVESLLSEKRIFEVAnamRHPFLVNLYSCFQTeqHVCFV 942  fruit fly
AAM91026   703 FRCISVLGRGHFGKVLLAEYkttkELFAIKALKKGDiisrDEVDSLMSEKRIFETAnsvRHPFLVNLFSCFQTkdHVCFV 782  Hydra vulgaris
NP_509742  684 FRLISVLGRGHFGKVILSQHnptsNYYALKVLKKGDilgrDEVESLMVEKRIFEVSsraRHPFLVNLNGCFQTneHVFFC 763  nematode
AAB92244   635 FRCISVLGRGHFGKVLLAEYkntgELFAIKALKKGDiiarEEVESLMCESRILETAnsmRHPFLVNLFACFQTdaHVCFV 714  ochreous starfish
NP_037487  559 FRCLAVLGRGHFGKVLLVQFkgtgKYYAIKALKKQEvlsrDEIESLYCEKRILEAVgctGHPFLLSLLACFQTssHACFV 638  human
P36583     683 FTFLSVLGKGNFGKVMLAELksekQLYAIKVLKKEFilenDEVESTKSEKRVFLVAnreRHPFLVNLHSCFQTetRIYFV 762  Schizosaccharomy...
EAU86111   717 FNFLAVLGKGNFGKVMLAEEkktnGLYAIKVLKKEFiidnDEVESTRSEKRVFLTAakeRHPFLLGLHSCFQTetRIYFV 796  Coprinopsis cine...
P87253     817 FNFLAVLGKGNFGKVMLAETkksrKLYAIKVLKKEFiienDEVESIRSEKRVFLIAnreRHPFLTNLHACFQTetRVYFV 896  Neurospora crassa
CAM14026   577 FRLIAVLGRGHFGKVLLAEYkksgSMYAIKALKKGDivarDEVESLMCEKRIFEAVngaQHPFLVNLFACFQTpeHVCFV 656  zebrafish
Feature 1      ## #   # #                                   # # ## #         ##  #             
Q16513     737 MEYAaGGDLMMHIHTdvFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDteGFVKIADFGLCKEGMGYGDRTST 816  human
NP_788290  943 MEYAaGGDLMMHIHTdvFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDteGYVKIADFGLCKEGMGFGDRTGT 1022 fruit fly
AAM91026   783 MEYApGGDLMMHIHEevFSEPRTIFYSGCVILGLQYLHEHDIVYRDLKLDNLLLDaeGYVKIADFGLCKEGMGFGQKTGT 862  Hydra vulgaris
NP_509742  764 MEYSmGGDLMRHIHDdvFDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDreGYVKIADFGLCKENMGPFDKTST 843  nematode
AAB92244   715 MEYAiGGDLMMHIHTdvFSEPRTVFYAACVVLGLQYLHENNIVYRDLKLDNLLLDqeGFLKIADFGLCKEGMGFGDRTST 794  ochreous starfish
NP_037487  639 TEFVpGGDLMMQIHEdvFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDaqGFLKIADFGLCKEGIGFGDRTST 718  human
P36583     763 MDFVsGGDLMLHIQQeqFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNILLSpdGHVKVADYGLCKEDMWHDNTTAT 842  Schizosaccharomy...
EAU86111   797 MEYVsGGDLMLHIQRkqFSLRQAKFYASEVLLALEYFHQNGIIYRDLKLDNILLTldGHVKVADYGLCKEQMWYGQTTST 876  Coprinopsis cine...
P87253     897 MEYIsGGDLMLHIQRgmFGTKRAQFYAAEVCLALKYFHENGVIYRDLKLDNILLTldGHIKIADYGLCKEDMWYGSTTST 976  Neurospora crassa
CAM14026   657 MEYTaGGDLMMHIHAdvFTEPRAVFYSACVVLGLQFLHDNKIVYRDLKLDNLLLDteGYVKIADFGLCKEGMGFGDRTST 736  zebrafish
Feature 1      ######                          #     #  #                                      
Q16513     817 FCGTPEFLAPEVLTEtsYTRAVDWWGLGVLIYEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsTEAISIMRRLLRrNP 896  human
NP_788290 1023 FCGTPEFLAPEVLTEtsYTRAVDWWGLGVLIFEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsLEAIAVMRRLLRkNP 1102 fruit fly
AAM91026   863 FCGTPEFLAPEVLTEtsYTRAVDWWGLGVLIFEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsNDSIALMRRLLRkNP 942  Hydra vulgaris
NP_509742  844 FCGTPEFLAPEVLSDssYTRAIDWWGLGVLIFEMLVGEPPFSGDdeEEIFDSIISEDVRYPRYlsVESIAIMRRLLRkVP 923  nematode
AAB92244   795 FCGTPEFLAPEVLTEasYTRAVDWWGLGVLIFEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsTEAIAIMRRLLRrNP 874  ochreous starfish
NP_037487  719 FCGTPEFLAPEVLTQeaYTRAVDWWGLGVLLYEMLVGECPFPGDteEEVFDCIVNMDAPYPGFlsVQGLEFIQKLLQkCP 798  human
P36583     843 FCGTPEFMAPEILLEqqYTRSVDWWAFGVLIYQMLLGQSPFRGEdeEEIFDAILSDEPLYPIHmpRDSVSILQQLLTrDP 922  Schizosaccharomy...
EAU86111   877 FCGTPEFMAPEILLEqrYGRAVDWWAFGVLTYEMLLGQSPFRGDdeDEIFDAILEDEPLYPITmpRDAVSILQKLLTrDP 956  Coprinopsis cine...
P87253     977 FCGTPEFMAPEILLDkkYGRAVDWWAFGVLIYQMLLQQSPFRGEdeDEIYDAILADEPLYPIHmpRDSVSILQKLLTrEP 1056 Neurospora crassa
CAM14026   737 FCGTPEFLAPEVLTDtsYTRAVDWWGLGVLIYEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsAEAIGIMRRLLRrNP 816  zebrafish
Feature 1                                                                                      
Q16513     897 ERRLGASekDAEDVKKHPFFRLIDWSAlm--dKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPprepr-ilseeEQEM 973  human
NP_788290 1103 ERRLGSSerDAEDVKKQAFFRSIVWDDll--lRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPpkepr-hlteeEQLL 1179 fruit fly
AAM91026   943 ERRLGSSikDAEDIKKQPFYKDMKWDSli--qRKLKTPFIPTVKHPEDVSNFDSEFTSEDPVLTPakekr-glsqgEQAL 1019 Hydra vulgaris
NP_509742  924 EKRLGYGerDAEDIKIQRFFRHISWEWdkllnREIRPPFQPQIRNPEDVSNFDLEFTQEKARFSAasstr-piteaDQRL 1002 nematode
AAB92244   875 ERRLGSSrrDAEDVKKQAFFRNVQWEEll--mRKTTPPFVPNINHPEDVSNFDEEFTQERPVLTPptrdpraitdqEQNL 952  ochreous starfish
NP_037487  799 EKRLGAGeqDAEEIKVQPFFRTTNWQAll--aRTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPpaphs-lltarQQAA 875  human
P36583     923 KKRLGSGpnDAEDVMTHPFFSNINWDDiy--hKRTQPPYIPSLNSPTDTKYFDEEFTRELPVLTPvnsi---ltkeMQQH 997  Schizosaccharomy...
EAU86111   957 ARRLGSGkeDAEEIKRQPFFKDVNWDDvf--hKRIPPPYFPTISGSADTSNFDEEFTREQPTLTPvhgq---lssrDQAE 1031 Coprinopsis cine...
P87253    1057 DQRLGSGptDAQEIMSQPFFRNINWDDiy--hKRVQPPFLPQIKSATDTSNFDSEFTSVTPVLTPvqsv---lsqaMQEE 1131 Neurospora crassa
CAM14026   817 ERRLGSSekDAEDVKKQPFFRNMDWEAll--lRKLPPPFIPSIGGKEDVSNFDEEFTTEAPTLTPprepr-vlsrkDQDS 893  zebrafish
Feature 1             
Q16513     974 FRDFDYI 980  human
NP_788290 1180 FQDFSYT 1186 fruit fly
AAM91026  1020 FSGFEYT 1026 Hydra vulgaris
NP_509742 1003 FNNFDFS 1009 nematode
AAB92244   953 FKDFNYT 959  ochreous starfish
NP_037487  876 FRDFDFV 882  human
P36583     998 FEGFSYS 1004 Schizosaccharomyces pombe
EAU86111  1032 FNGFSWV 1038 Coprinopsis cinerea okayama7#130
P87253    1132 FRGFSYT 1138 Neurospora crassa
CAM14026   894 FRDFDYV 900  zebrafish

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