Conserved Protein Domain Family
STKc_PKN

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cd05589: STKc_PKN (this model, PSSM-Id:173680 is obsolete and has been replaced by 270741)
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase N
Serine/Threonine Kinases (STKs), Protein Kinase N (PKN) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis.
Statistics
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PSSM-Id: 173680
View PSSM: cd05589
Aligned: 15 rows
Threshold Bit Score: 594.737
Threshold Setting Gi: 40254851
Created: 23-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #####   #            # #                                  #               
gi 6225859    657 FRCCAVLGRGHFGKVLLAEYkntnEMFAIKALKKGDivarDEVDSLMCEKRIFETVnsvRHPFLVNLFACFQTkeHVCFV 736
gi 28573939   863 FRLLSVLGRGHFGKVILSQLrsnnQYYAIKALKKGDiiarDEVESLLSEKRIFEVAnamRHPFLVNLYSCFQTeqHVCFV 942
gi 22087742   703 FRCISVLGRGHFGKVLLAEYkttkELFAIKALKKGDiisrDEVDSLMSEKRIFETAnsvRHPFLVNLFSCFQTkdHVCFV 782
gi 25146933   684 FRLISVLGRGHFGKVILSQHnptsNYYALKVLKKGDilgrDEVESLMVEKRIFEVSsraRHPFLVNLNGCFQTneHVFFC 763
gi 2707262    635 FRCISVLGRGHFGKVLLAEYkntgELFAIKALKKGDiiarEEVESLMCESRILETAnsmRHPFLVNLFACFQTdaHVCFV 714
gi 40254851   559 FRCLAVLGRGHFGKVLLVQFkgtgKYYAIKALKKQEvlsrDEIESLYCEKRILEAVgctGHPFLLSLLACFQTssHACFV 638
gi 7404419    683 FTFLSVLGKGNFGKVMLAELksekQLYAIKVLKKEFilenDEVESTKSEKRVFLVAnreRHPFLVNLHSCFQTetRIYFV 762
gi 116503216  717 FNFLAVLGKGNFGKVMLAEEkktnGLYAIKVLKKEFiidnDEVESTRSEKRVFLTAakeRHPFLLGLHSCFQTetRIYFV 796
gi 67476858   817 FNFLAVLGKGNFGKVMLAETkksrKLYAIKVLKKEFiienDEVESIRSEKRVFLIAnreRHPFLTNLHACFQTetRVYFV 896
gi 122890948  577 FRLIAVLGRGHFGKVLLAEYkksgSMYAIKALKKGDivarDEVESLMCEKRIFEAVngaQHPFLVNLFACFQTpeHVCFV 656
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ## #   # #                                   # # ## #         ##  #             
gi 6225859    737 MEYAaGGDLMMHIHTdvFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDteGFVKIADFGLCKEGMGYGDRTST 816
gi 28573939   943 MEYAaGGDLMMHIHTdvFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDteGYVKIADFGLCKEGMGFGDRTGT 1022
gi 22087742   783 MEYApGGDLMMHIHEevFSEPRTIFYSGCVILGLQYLHEHDIVYRDLKLDNLLLDaeGYVKIADFGLCKEGMGFGQKTGT 862
gi 25146933   764 MEYSmGGDLMRHIHDdvFDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDreGYVKIADFGLCKENMGPFDKTST 843
gi 2707262    715 MEYAiGGDLMMHIHTdvFSEPRTVFYAACVVLGLQYLHENNIVYRDLKLDNLLLDqeGFLKIADFGLCKEGMGFGDRTST 794
gi 40254851   639 TEFVpGGDLMMQIHEdvFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDaqGFLKIADFGLCKEGIGFGDRTST 718
gi 7404419    763 MDFVsGGDLMLHIQQeqFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNILLSpdGHVKVADYGLCKEDMWHDNTTAT 842
gi 116503216  797 MEYVsGGDLMLHIQRkqFSLRQAKFYASEVLLALEYFHQNGIIYRDLKLDNILLTldGHVKVADYGLCKEQMWYGQTTST 876
gi 67476858   897 MEYIsGGDLMLHIQRgmFGTKRAQFYAAEVCLALKYFHENGVIYRDLKLDNILLTldGHIKIADYGLCKEDMWYGSTTST 976
gi 122890948  657 MEYTaGGDLMMHIHAdvFTEPRAVFYSACVVLGLQFLHDNKIVYRDLKLDNLLLDteGYVKIADFGLCKEGMGFGDRTST 736
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ######                          #     #  #                                      
gi 6225859    817 FCGTPEFLAPEVLTEtsYTRAVDWWGLGVLIYEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsTEAISIMRRLLRrNP 896
gi 28573939  1023 FCGTPEFLAPEVLTEtsYTRAVDWWGLGVLIFEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsLEAIAVMRRLLRkNP 1102
gi 22087742   863 FCGTPEFLAPEVLTEtsYTRAVDWWGLGVLIFEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsNDSIALMRRLLRkNP 942
gi 25146933   844 FCGTPEFLAPEVLSDssYTRAIDWWGLGVLIFEMLVGEPPFSGDdeEEIFDSIISEDVRYPRYlsVESIAIMRRLLRkVP 923
gi 2707262    795 FCGTPEFLAPEVLTEasYTRAVDWWGLGVLIFEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsTEAIAIMRRLLRrNP 874
gi 40254851   719 FCGTPEFLAPEVLTQeaYTRAVDWWGLGVLLYEMLVGECPFPGDteEEVFDCIVNMDAPYPGFlsVQGLEFIQKLLQkCP 798
gi 7404419    843 FCGTPEFMAPEILLEqqYTRSVDWWAFGVLIYQMLLGQSPFRGEdeEEIFDAILSDEPLYPIHmpRDSVSILQQLLTrDP 922
gi 116503216  877 FCGTPEFMAPEILLEqrYGRAVDWWAFGVLTYEMLLGQSPFRGDdeDEIFDAILEDEPLYPITmpRDAVSILQKLLTrDP 956
gi 67476858   977 FCGTPEFMAPEILLDkkYGRAVDWWAFGVLIYQMLLQQSPFRGEdeDEIYDAILADEPLYPIHmpRDSVSILQKLLTrEP 1056
gi 122890948  737 FCGTPEFLAPEVLTDtsYTRAVDWWGLGVLIYEMLVGESPFPGDdeEEVFDSIVNDEVRYPRFlsAEAIGIMRRLLRrNP 816
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 6225859    897 ERRLGASekDAEDVKKHPFFRLIDWSAlm--dKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPprepr-ilseeEQEM 973
gi 28573939  1103 ERRLGSSerDAEDVKKQAFFRSIVWDDll--lRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPpkepr-hlteeEQLL 1179
gi 22087742   943 ERRLGSSikDAEDIKKQPFYKDMKWDSli--qRKLKTPFIPTVKHPEDVSNFDSEFTSEDPVLTPakekr-glsqgEQAL 1019
gi 25146933   924 EKRLGYGerDAEDIKIQRFFRHISWEWdkllnREIRPPFQPQIRNPEDVSNFDLEFTQEKARFSAasstr-piteaDQRL 1002
gi 2707262    875 ERRLGSSrrDAEDVKKQAFFRNVQWEEll--mRKTTPPFVPNINHPEDVSNFDEEFTQERPVLTPptrdpraitdqEQNL 952
gi 40254851   799 EKRLGAGeqDAEEIKVQPFFRTTNWQAll--aRTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPpaphs-lltarQQAA 875
gi 7404419    923 KKRLGSGpnDAEDVMTHPFFSNINWDDiy--hKRTQPPYIPSLNSPTDTKYFDEEFTRELPVLTPvnsi---ltkeMQQH 997
gi 116503216  957 ARRLGSGkeDAEEIKRQPFFKDVNWDDvf--hKRIPPPYFPTISGSADTSNFDEEFTREQPTLTPvhgq---lssrDQAE 1031
gi 67476858  1057 DQRLGSGptDAQEIMSQPFFRNINWDDiy--hKRVQPPFLPQIKSATDTSNFDSEFTSVTPVLTPvqsv---lsqaMQEE 1131
gi 122890948  817 ERRLGSSekDAEDVKKQPFFRNMDWEAll--lRKLPPPFIPSIGGKEDVSNFDEEFTTEAPTLTPprepr-vlsrkDQDS 893

                  ....*..
Feature 1                
gi 6225859    974 FRDFDYI 980
gi 28573939  1180 FQDFSYT 1186
gi 22087742  1020 FSGFEYT 1026
gi 25146933  1003 FNNFDFS 1009
gi 2707262    953 FKDFNYT 959
gi 40254851   876 FRDFDFV 882
gi 7404419    998 FEGFSYS 1004
gi 116503216 1032 FNGFSWV 1038
gi 67476858  1132 FRGFSYT 1138
gi 122890948  894 FRDFDYV 900

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