Conserved Protein Domain Family
STKc_Sck1_like

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cd05586: STKc_Sck1_like (this model, PSSM-Id:173677 is obsolete and has been replaced by 270738)
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Protein Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Fission yeast Suppressor of loss of cAMP-dependent protein kinase (Sck1)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of fungal proteins with similarity to the Schizosaccharomyces pombe STK Sck1. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes.
Statistics
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PSSM-Id: 173677
View PSSM: cd05586
Aligned: 3 rows
Threshold Bit Score: 688.211
Threshold Setting Gi: 50254457
Created: 12-Oct-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #####   #            # #                                  #               ## #  
gi 19860360 308 IGKGTFGQVYLVRKndtnRIYAMKKISKKlivrkkevTHTLGERNILVRTsldeSPFIVGLKFSFQTasDLYLITDYMsG 387
gi 50254457 391 IGRGTFGRVFQVRKkdtrRIYAMKVLSKKeivakkevAHTIGERKILQCSl--eCPFLVGLKFSFQTdtELYFVTDYKcG 468
gi 85117676 512 IGKGTFGQVYQVRKkdtgRIYAMKVLSKKvivqkkevAHTVGERNILVRTamsdSPFIVGLKFSFQTpsDLYLVTDYMsG 591
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #                                    # # ## #         ##  #             #####
gi 19860360 388 GELFWHLQHegrFPEQRAKFYIAELVLALEHLHkHDIIYRDLKPENILLDadGHIALCDFGLSKANLSANATTNTFCGTT 467
gi 50254457 469 GELFWHLQKegrFSEDRARFYIAELVLALEHLHkYNIVYRDLKPENILLDatGHVALCDFGLSKPDLTDDKLTNTFCGTT 548
gi 85117676 592 GELFWHLQKdgkFEEKRAKFYIAELILAIQHLHeNDIVYRDLKPENILLDanGHIALCDFGLSKANLTKNDTTNTFCGTT 671
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       #                           #     #  #                                          
gi 19860360 468 EYLAPEVLLEdkgytKQVDFWSLGVLVFEMCCGWSPFYAPdvqQMYRNIAfgKVRFPKgvlsSEGRSFVRGLLNrnPNHR 547
gi 50254457 549 EYLAPEVLLDekgygKHVDFWSLGVLLFEMCCGWSPFYAEqtqEMYRLICygKIRFPKnvigDDGKQFVKGLLNrnPQNR 628
gi 85117676 672 EYLAPEVLLDeagytKMVDFWSLGVLVFEMCCGWSPFYAEdtqQMYKNIAfgKVRFPRdtlsLEGRNFVKGLLNrnPKHR 751
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 19860360 548 LGavadttELKEHPFFADINWDllskkkvqPPFKPNVQNDLDVSNFDKEFTNtnvkninivsnv---------------- 611
gi 50254457 629 LGshrgavELKEHPFFKNIDWDllykkqitPPFKPIVDSDESVANFDPEFTNsslldagivpwedvnatvdpgtasqpgk 708
gi 85117676 752 LGatddaeELKRHAFFADIDWDalskklitPPFKPQLKSDTDVSYFDPEFTNalnangslneraaa-------------- 817
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         
gi 19860360 612 ----------------------------dpanastplsnTIQDRFRGFTF 633
gi 50254457 709 hsylgpgagisgsvpgggvainkaqrpglpgangspltsSVQENFRGFTY 758
gi 85117676 818 --------------------------largyatstplspSVQANFQGFTF 841

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