Conserved Protein Domain Family
STKc_Sck1_like

?
cd05586: STKc_Sck1_like (this model, PSSM-Id:173677 is obsolete and has been replaced by 270738)
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Protein Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Fission yeast Suppressor of loss of cAMP-dependent protein kinase (Sck1)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of fungal proteins with similarity to the Schizosaccharomyces pombe STK Sck1. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes.
Statistics
?
PSSM-Id: 173677
Aligned: 3 rows
Threshold Bit Score: 688.211
Threshold Setting Gi: 50254457
Created: 12-Oct-2007
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1     #####   #            # #                                  #               ## #  
P50530    308 IGKGTFGQVYLVRKndtnRIYAMKKISKKlivrkkevTHTLGERNILVRTsldeSPFIVGLKFSFQTasDLYLITDYMsG 387 Schizosaccharomyce...
EAL17206  391 IGRGTFGRVFQVRKkdtrRIYAMKVLSKKeivakkevAHTIGERKILQCSl--eCPFLVGLKFSFQTdtELYFVTDYKcG 468 Cryptococcus neofo...
XP_965300 512 IGKGTFGQVYQVRKkdtgRIYAMKVLSKKvivqkkevAHTVGERNILVRTamsdSPFIVGLKFSFQTpsDLYLVTDYMsG 591 Neurospora crassa ...
EAL17206  391 IGRGTFGRVFQVRKkdtrRIYAMKVLSKKeivakkevAHTIGERKILQCSl--eCPFLVGLKFSFQTdtELYFVTDYKcG 468 Cryptococcus neofo...
XP_965300 512 IGKGTFGQVYQVRKkdtgRIYAMKVLSKKvivqkkevAHTVGERNILVRTamsdSPFIVGLKFSFQTpsDLYLVTDYMsG 591 Neurospora crassa ...
Feature 1      # #                                    # # ## #         ##  #             #####
P50530    388 GELFWHLQHegrFPEQRAKFYIAELVLALEHLHkHDIIYRDLKPENILLDadGHIALCDFGLSKANLSANATTNTFCGTT 467 Schizosaccharomyce...
EAL17206  469 GELFWHLQKegrFSEDRARFYIAELVLALEHLHkYNIVYRDLKPENILLDatGHVALCDFGLSKPDLTDDKLTNTFCGTT 548 Cryptococcus neofo...
XP_965300 592 GELFWHLQKdgkFEEKRAKFYIAELILAIQHLHeNDIVYRDLKPENILLDanGHIALCDFGLSKANLTKNDTTNTFCGTT 671 Neurospora crassa ...
EAL17206  469 GELFWHLQKegrFSEDRARFYIAELVLALEHLHkYNIVYRDLKPENILLDatGHVALCDFGLSKPDLTDDKLTNTFCGTT 548 Cryptococcus neofo...
XP_965300 592 GELFWHLQKdgkFEEKRAKFYIAELILAIQHLHeNDIVYRDLKPENILLDanGHIALCDFGLSKANLTKNDTTNTFCGTT 671 Neurospora crassa ...
Feature 1     #                           #     #  #                                          
P50530    468 EYLAPEVLLEdkgytKQVDFWSLGVLVFEMCCGWSPFYAPdvqQMYRNIAfgKVRFPKgvlsSEGRSFVRGLLNrnPNHR 547 Schizosaccharomyce...
EAL17206  549 EYLAPEVLLDekgygKHVDFWSLGVLLFEMCCGWSPFYAEqtqEMYRLICygKIRFPKnvigDDGKQFVKGLLNrnPQNR 628 Cryptococcus neofo...
XP_965300 672 EYLAPEVLLDeagytKMVDFWSLGVLVFEMCCGWSPFYAEdtqQMYKNIAfgKVRFPRdtlsLEGRNFVKGLLNrnPKHR 751 Neurospora crassa ...
EAL17206  549 EYLAPEVLLDekgygKHVDFWSLGVLLFEMCCGWSPFYAEqtqEMYRLICygKIRFPKnvigDDGKQFVKGLLNrnPQNR 628 Cryptococcus neofo...
XP_965300 672 EYLAPEVLLDeagytKMVDFWSLGVLVFEMCCGWSPFYAEdtqQMYKNIAfgKVRFPRdtlsLEGRNFVKGLLNrnPKHR 751 Neurospora crassa ...
Feature 1                                                                                     
P50530    548 LGavadttELKEHPFFADINWDllskkkvqPPFKPNVQNDLDVSNFDKEFTNtnvkninivsnv---------------- 611 Schizosaccharomyce...
EAL17206  629 LGshrgavELKEHPFFKNIDWDllykkqitPPFKPIVDSDESVANFDPEFTNsslldagivpwedvnatvdpgtasqpgk 708 Cryptococcus neofo...
XP_965300 752 LGatddaeELKRHAFFADIDWDalskklitPPFKPQLKSDTDVSYFDPEFTNalnangslneraaa-------------- 817 Neurospora crassa ...
EAL17206  629 LGshrgavELKEHPFFKNIDWDllykkqitPPFKPIVDSDESVANFDPEFTNsslldagivpwedvnatvdpgtasqpgk 708 Cryptococcus neofo...
XP_965300 752 LGatddaeELKRHAFFADIDWDalskklitPPFKPQLKSDTDVSYFDPEFTNalnangslneraaa-------------- 817 Neurospora crassa ...
Feature 1                                                       
P50530    612 ----------------------------dpanastplsnTIQDRFRGFTF 633 Schizosaccharomyces pombe
EAL17206  709 hsylgpgagisgsvpgggvainkaqrpglpgangspltsSVQENFRGFTY 758 Cryptococcus neoformans var. neoformans B-3501A
XP_965300 818 --------------------------largyatstplspSVQANFQGFTF 841 Neurospora crassa OR74A
EAL17206  709 hsylgpgagisgsvpgggvainkaqrpglpgangspltsSVQENFRGFTY 758 Cryptococcus neoformans var. neoformans B-3501A
XP_965300 818 --------------------------largyatstplspSVQANFQGFTF 841 Neurospora crassa OR74A

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap