Conserved Protein Domain Family
STKc_p70S6K

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cd05584: STKc_p70S6K (this model, PSSM-Id:173675 is obsolete and has been replaced by 270736)
Catalytic domain of the Protein Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
Serine/Threonine Kinases (STKs), 70 kDa ribosomal protein S6 kinase (p70S6K) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta).
Statistics
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PSSM-Id: 173675
View PSSM: cd05584
Aligned: 11 rows
Threshold Bit Score: 649.166
Threshold Setting Gi: 12620233
Created: 23-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #####   #                   # #                                #             
Q9UBS0        70 LRVLGKGGYGKVFQVRKVqgt----nlGKIYAMKVLRKAKIVRNAKdtAHTRAERNILESVkHPFIVELAYAFQTggKLY 145 human
NP_001025892  71 LRVLGKGGYGKVFQVRKVtga----ntGKIFAMKVLKKAMIVRSAKdtAHTKAERNIVEEVkHPFIVDLIYAFQTggKLY 146 chicken
AAH46888      68 LRVLGKGGYGKVFQVRKVsga----atGKIFAMKVLKKAMIVRNAKdtAHTKAERNILEEVkHPFIVDLIYAFQTggKLY 143 zebrafish
AAH73469      40 LRVLGKGGYGKVFQVRKViga----htGKIFAMKVLKKAMIVRNAKdtAHTKAERNILEEVkHPFIVDLIYAFQTggKLY 115 African clawed ...
NP_499447     86 LKVLGKGGYGKVFQVRKTtgs----dnGQIFAMKVLQKATIVRNQKdtAHTKAERNILEAVkSPFICDLLYAFQTggKLY 161 nematode
XP_781234     75 LKVLGKGGYGKVFQVRKTtgk----dsGKIFAMKVLKKAKIVRNQKdtAHTKAERNILEAVqHPFIVDLHYAFQTggKLY 150 purple urchin
AAC47429      80 KKVLGKGGYGKVFQVRKTagr----daNKYFAMKVLKKASIVTNQKdtAHTRAERNILEAVkHPFIVELVYAFQTdgKLY 155 fruit fly
AAG60621      77 ISLLGKGGYGKVLLAEMLdeskskydpPRLYAMKVLKKATIARNQKdtAHTRAERNILEAVkHPFIVDLHYAFQTdgKLY 156 California sea ...
XP_001633229  68 LKVLGKGGYGKVFLVKKNhgh----skEKIFAMKVLKKAAIIRSQKdtAHTKAERNILECVkHPFIVDLIYAFQTggKLY 143 starlet sea ane...
AAG48248      79 RKVLGKGGYGKVFQVRKLtgq----dsGHTFAMKVLKKATIVRNQKdtAHTKAERNILEAVkHPFIVDLIYAFQTggKLY 154 Artemia francis...
NP_003152     94 LRVLGKGGYGKVFQVRKVtga----ntGKIFAMKVLKKAMIVRNAKdtAHTKAERNILEEVkHPFIVDLIYAFQTggKLY 169 human
Feature 1          ## #   # #                                    # # ## #         ##  #          
Q9UBS0       146 LILECLsGGELFTHLERegiFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSsqGHIKLTDFGLCKESIHEGAV 225 human
NP_001025892 147 LILEYLsGGELFMQLERegiFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNhqGHVKLTDFGLCKESIHDGTV 226 chicken
AAH46888     144 LILEYLsGGELFMQLERegiFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNnqGHVKLTDFGLCKESIHDGTV 223 zebrafish
AAH73469     116 LILEYLsGGELFMQLERegiFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNlqGHVKLTDFGLCKESIHDGTV 195 African clawed ...
NP_499447    162 LILEYLsGGELFMHLERegmFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDayGHVKLTDFGLCKEEIEGDQK 241 nematode
XP_781234    151 LILAYLgGGELFMHLERegiFMEDTACFYLSEIVLALEHLHKLGIIYRDLKPENIMLNkqGHVVLTDFGLCKESLEEGSM 230 purple urchin
AAC47429     156 LILEYLsGGELFMHLERegiFLEDTTCFYLSEIIFALGHLHKLGIIYRDLKPENILLDaqGHVKLTDFGLCKEHIQEGIV 235 fruit fly
AAG60621     157 LILEYLpGGELFTHLERegiFMEDMASFYLGEILLAIEHLHTLGVIYRDLKPENVLLDckGHIKLTDFGLCKESISLGEV 236 California sea ...
XP_001633229 144 LILEYLsGGELFMQLERegiFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDanGHVKLTDFGLCKESIFENSL 223 starlet sea ane...
AAG48248     155 LILEYLsGGELFMHLERegiFMEDTACFYLSEIILALEHLHHQGIIYRDLKPENILLDaqGHVKLTDFGLCKESVIEGSV 234 Artemia francis...
NP_003152    170 LILEYLsGGELFMQLERegiFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNhqGHVKLTDFGLCKESIHDGTV 249 human
Feature 1           ######                          #     #  #                                   
Q9UBS0       226 THTFCGTIEYMAPEILVRsghNRAVDWWSLGALMYDMLTGSPPFTAEnrKKTMDKIIRGKLALPPYltPDARDLVKKFLK 305 human
NP_001025892 227 THTFCGTIEYMAPEILMRsghNRAVDWWSLGALMYDMLTGAPPFTGEnrKKTIDKILKCKLNLPPYltQEARDLLKKLLK 306 chicken
AAH46888     224 THTFCGTIEYMAPEILMRsghNRAVDWWSLGALMYDMLTGAPPFTGEnrKKTIDKILKCKLNLPPYltQEARDLLKRLLK 303 zebrafish
AAH73469     196 THTFCGTIEYMAPEILMRsghNRAVDWWSLGALMYDMLTGAPPFSGEnrKKTIDKILKCKLNLPPYltQEARDLLKKLLK 275 African clawed ...
NP_499447    242 THTFCGTIEYMAPEILMRcghGKAVDWWSLGALMFDMLTGGPPFTAEnrRKTIDKILKGRLTLPAYlsNEARDLIKKLLK 321 nematode
XP_781234    231 THTFCGTIEYMAPEIVSRsghGKDVDWWSLGALMYDMLTGGPPFTAEnrKKTIEKILKGKLSLPPYltHEARDLVRKLLK 310 purple urchin
AAC47429     236 THTFCGTIEYMAPEILTRsghGKAVDWWSLGALMFDMLTGVPPFTAEnrKKTIETILKAKLNLPAYltPEARDLVRRLMK 315 fruit fly
AAG60621     237 THTFCGTIEYMAPEIVQRsghGKGVDWWSLGALMYDMLTGQPPFSGEnrKKTIDKILRAKLSLPPYltNEARALLKKLLK 316 California sea ...
XP_001633229 224 THTFCGTIEYMAPEILTRsghGKAVDWWSLGALMYDMLTGTPPFCADnrKKTIDKILKGKLIIPPYltPEAKDFIRKLLK 303 starlet sea ane...
AAG48248     235 THTFCGTIEYMAPEILTRsghGKAVDWWSLGALMYDMLTGAPPFTAEnrKKTIEKILKGKLNLPPYlsPDARDLIRKLLK 314 Artemia francis...
NP_003152    250 THTFCGTIEYMAPEILMRsghNRAVDWWSLGALMYDMLTGAPPFTGEnrKKTIDKILKCKLNLPPYltQEARDLLKKLLK 329 human
Feature 1                                                                                        
Q9UBS0       306 rnPSQRIGGgpgdaADVQRHPFFRHMNWDDLLAWRVDPPFRPCLqseeDVSQFDTRFTRQTPVDSPDDtalsesaNQAFL 385 human
NP_001025892 307 rnAASRLGAgpgdaGEVQAHPFFRHINWDELLARKVEPPFKPLLqseeDVSQFDSKFTRQTPVDSPDDstlsesaNQVFL 386 chicken
AAH46888     304 rsASSRLGAgpgdaTEVQTHPFFRHVNWDDLLARKVEPPFKPFLqfaeDVSQFDSKFTSQTPVDSPDDstlsesaNQVFL 383 zebrafish
AAH73469     276 rnAASRLGAgvgdaGDVQGHSFFRHINWDDLLARKVEPPFKPLLqseeDVSQFDSKFTRQTPVDSPDDatlsesaNQVFV 355 African clawed ...
NP_499447    322 rhVDTRLGAglsdaEEIKSHAFFKTTDWNLVYARQLEAPFKPNIendeDTSLFDARFTKMTPVDSPCEtnfslngDNPFV 401 nematode
XP_781234    311 rhISARLGSgpedaTRIRKHPFFRHVKWDDVLARKGEPPITPAVvneeDVSQFDSKFTKQTPVDSPDDsmlsesaNQIFL 390 purple urchin
AAC47429     316 rqEPQRLGSgpedaAAVQIHPFFKHVNWDDVLARRLEPPIKPLLrsedDVSQFDTRFTRQIPVDSPDDttlsesaNLIFQ 395 fruit fly
AAG60621     317 knPSDRLGSgpddaAPIKSHMFFRHTNWDDLLNKRIEPPIKIGVtsayDVSLFDTKFTKQTPCDSPVDmtvfspsINIFD 396 California sea ...
XP_001633229 304 rhPQARLGGmagdaNPIKAHSFFRHICWEDLLAKKVEPPFRPSIsgeeDVSQFDSKFTRQTPVDSPDDsmlsesaSNIFQ 383 starlet sea ane...
AAG48248     315 rtVNQRLGSgpedgESLKDHPFFRLVNWNDVLMRRVDPPFKPALtsedDVSQFDTRFTKQTPVDSPDEstlsesaNLVFQ 394 Artemia francis...
NP_003152    330 rnAASRLGAgpgdaGEVQAHPFFRHINWEELLARKVEPPFKPLLqseeDVSQFDSKFTRQTPVDSPDDstlsesaNQVFL 409 human
Feature 1               
Q9UBS0       386 GFTYVAP 392 human
NP_001025892 387 GFTYVAP 393 chicken
AAH46888     384 GFTYVAP 390 zebrafish
AAH73469     356 GFTYVAP 362 African clawed frog
NP_499447    402 GFTYVAP 408 nematode
XP_781234    391 GFTYVAP 397 purple urchin
AAC47429     396 GFTYVAP 402 fruit fly
AAG60621     397 GFTYVAP 403 California sea hare
XP_001633229 384 GFTYVAP 390 starlet sea anemone
AAG48248     395 GFTYVAP 401 Artemia franciscana
NP_003152    410 GFTYVAP 416 human

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