Conserved Protein Domain Family
STKc_Yank1

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cd05578: STKc_Yank1 (this model, PSSM-Id:173669 is obsolete and has been replaced by 270730)
Catalytic domain of the Protein Serine/Threonine Kinase, Yank1
Serine/Threonine Kinases (STKs), Yank1 or STK32A subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily contains uncharacterized STKs with similarity to the human protein designated Yank1 or STK32A.
Statistics
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PSSM-Id: 173669
View PSSM: cd05578
Aligned: 12 rows
Threshold Bit Score: 383.975
Threshold Setting Gi: 3218400
Created: 4-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #####   #            # #                               #               ##
gi 93140693   22 HFEILRAIGKGSFGKVCIVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 101
gi 3218400    29 QFKIRNVIGKGSWSTVFVVKHrqtKQRFALKCINKKKHde-hkIKKLRNEVLLLQSLnHPLLCKFYSEFEDetKIYLVTD 107
gi 71043946   22 HFEILRAIGKGSFGKVCVVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 101
gi 49117936   22 HFEILRAIGKGSFGKVCIVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 101
gi 58262942   21 HFYLLRSVGKGAFGKVRVVQHkhtKTLFALKYINKQKCvkmraVANIVQERRLLEEIdHPFVVNLRYAFQDdeNCFFVLD 100
gi 17554256   27 HFSVIRSIGRGAFGKVCIVQErktKKYFALKYMNKRRCiekgvAANVIRELTLLSKMsHPFIVNLWYTFQDgdYMYMVSD 106
gi 50551661   63 NYELLQVVGSGAFSKVRVVRQmttNNVYALKYSVREDIvklgrTQLMLNERRILLRLqHPFLCNLHQTFCDseYLYTLLD 142
gi 14582566   18 HFRLLRVVGRGAFGKVRIVERrdtGLTFALKYIRKGDVirtesVRNILRERRMLEQLnYQFICNLRYSFQDieYMYLVVD 97
gi 115869839  22 HFQILRAIGKGSFGKVCIVQKrdtKKMYAMKYMNKAMCirkdaVRNVLREQEILQALeHPFLVNLWFTFQDeeDMFMVVD 101
gi 89297469   57 GYIFNQVIGKGGFGKVWNVQKrknKEVLAMKIMSKVKIlskksVNSVLNERKILSHLnHPLIVNMHNSFQDreNLYLTMD 136
gi 124421919 219 HFIYNYVIGKGGFGKVWKVELkknRQMFAMKEMMKSKIiakrsINSVMNEKELLSQLrHPFLVNMCYAFQDrdNLYLIMD 298
gi 2104851    33 HFLLQYIIGVGGFGRVWKVSYk--QQVFAMKEISKALVllkqsVQSIMNELQFLTELrHNLLVNVFSAFQDnqNLYLVLD 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #   # #                                     # # ## #         ##  #             
gi 93140693  102 LLlGGDLRYHLQQn-vHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDehGHVHITDFNIAAMLPRet----- 175
gi 3218400   108 LMlGGDLRYHISQr--KFNESVIRIWMVELVSALIYIHSKGVLHRDVKPDNILLDekGHCKLADFNVAAKVHTssspsks 185
gi 71043946  102 LLlGGDLRYHLQQk-vRFQEGTVKLFICELVLALDYLQSRHIIHRDIKPDNILLDehGHVHITDFNIATMLTKet----- 175
gi 49117936  102 LLlGGDLRYHLQQn-vRFTEASVKLYICELALALDYLQSKSIIHRDIKPDNVLLDeqGHVHITDFNIATLVSKgt----- 175
gi 58262942  101 LMlGGDLRFHLDRa-gAMSEEIVRFYVAEIALAIDYLHSKRIVHRDLKPDNILLDekGHAHITDFNIAVHFSDrr----- 174
gi 17554256  107 LLlGGDLRYHLSQq-gKFAEDRAKLYLCEICLAVEYLHEMKIVHRDIKPENILLDeqGHAHLTDLNLATQLEDdq----- 180
gi 50551661  143 LMtGGDLRWHIERk--TFSEATIRFWVVEVACAVAYLHEKGVVHRDIKPDNIMLDelGHARLGDFNVACMLPYge----- 215
gi 14582566   98 LMnGGDLRFHISRk--VFTEEAVRFWISELGLAIRYIHSQGIIHRDIKPDNVLLDaeGHVHLADFNVASDFTPgk----- 170
gi 115869839 102 LLlGGDLRYHILQg-vKFDAERVKLYLCEITLALDYLRTHLIIHRDIKPDNILLDedGHVHITDFNIATIVKAnv----- 175
gi 89297469  137 FIgGGDLRYHLIHqtePFSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDesGYLKVTDFGISRIWKPd------ 210
gi 124421919 299 LLtGGDLRYHIGKm-kRFKEHQTKFFIACIVSGLEYLHNNNIIHRDIKPENIVLDkrGYARITDLGIARKVRPd------ 371
gi 2104851   111 YLgGGDLRFHLGKl-rKFTEEQTKFFAACIIVGLEYLHEKNIIHRDIKPENLILDnqGYVRITDLGVAIKKTGq------ 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ######                               #     #  #                            
gi 93140693  176 -qITTMAGTKPYMAPEMFSSrkga--gysFAVDWWSLGVTAYELLRGRRPYHIRSst-sSKEIVHTFEt----TVVTYPS 247
gi 3218400   186 nmTVGRVGTPVYMAPETLIHav-----syKESDWWSLGITFYECLFQVRPFPNHLl---INWIRASEEekassADRLSSA 257
gi 71043946  176 -qVTTIAGTKPYMAPEMFNStkpi--gysFAVDWWSLGITAYELLRARRPYHIHSnt-pTNEIAHVFKt----ATVMYPA 247
gi 49117936  176 -kITTVAGTKPYMAPEMFCPrgqi--cysFAVDWWSLGVTAYELLRGRRPFHIHSst-aATDIVHVFHt----ATVTYPP 247
gi 58262942  175 -lLTGVAGSMAYMAPEVLTKrg-----ysAPVDFWSLGILAYELLFGKRPFRGRT----NSGLTNSIL-----NEPLSWP 239
gi 17554256  181 -lATSYSGTRPYMAPEIYATyleiedgydSRVDWWALGVCFYEMLRGRTPFEFSSrtkpEEAYVAFRE-----SSIPYPA 254
gi 50551661  216 ykTDSGCGTIGYMAPEVVRAky------nHLVDWWSLGAVFYECLYGTVPYRYHS----TDEYRRMKLk---eHSNLFPV 282
gi 14582566  171 -lLTSKSGTLAYLAPEVYKGkg-----ysSSVDWWSLGVLFYECIYNKRPFEKISs---SDLQEQILK-----ADPKFPV 236
gi 115869839 176 -yGTSMSGTKPYMAPEIFQTatddckgysYPVDWWSLGVCAYEMLRTKRPYDIHAns-sIADIQHLFSt----NTVHYPS 249
gi 89297469  211 -nSNETSGTPGYIAPEILMRqn-----ygVAVDYYALGIIMYEMAMGKRPYKAKDrkelREQILAKQVq---iKREEIPK 281
gi 124421919 372 -nSQDTSGTPGYMAPEVMCRqn-----hgIAVDYFALGVIAYEFMIGKRPYNGKSrkeiRDQILAKQAs---iKKEDLPN 442
gi 2104851   184 --NFETSGTPGYMAPEVIFRqd-----hgVAVDFFALGVICYEFMTGRRPYYGNRre-iREQIIAKQV-----QIQTSSE 250
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          
gi 93140693  248 AWs----------QEMVSLLKKLLEPNPDQRFSq------lSDVQNFPYM 281
gi 3218400   258 LHisrdkklttisKDARSAVMAFLEMDIKKRLGhs-----sKKLQTHPFF 302
gi 71043946  248 AWs----------EEMVMLIKKLLETNPDKRFSq------lKDIQDFPYL 281
gi 49117936  248 AWs----------KEIVSLLHKLLDRNTEERFSs------lETIQDFPYL 281
gi 58262942  240 EDapg-----rcsSDGMHAIRGFLERDPNKRLGyrpggggmDDIKNHPWF 284
gi 17554256  255 HWp----------TDLIQFINSMLKFDKEKRLVg------lEAIKKHSYT 288
gi 50551661  283 TQpq-------vsMAAIEALDLLLTVEAQYRLHd------vDQLLQLSYF 319
gi 14582566  237 TDpp-------vsIVCMHAISSALEQDPNKRMGctkd-egfSSFTDNPFF 278
gi 115869839 250 TWn----------PSLTDLIRQLLSVDPRERISd------lESLSKHPFM 283
gi 89297469  282 GWs----------LEAIDFINRLIQRKPSNRLGvn----gpQEVKDHVWI 317
gi 124421919 443 GWs----------IEAMDFVNKLLQRKPQNRLGfn----gpSDVKNHPWL 478
gi 2104851   251 GWs----------TESIDFINLLLQRKPQNRLMnpr---qhKWFKNFPFD 287

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