Conserved Protein Domain Family
STKc_Yank1

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cd05578: STKc_Yank1 (this model, PSSM-Id:173669 is obsolete and has been replaced by 270730)
Catalytic domain of the Protein Serine/Threonine Kinase, Yank1
Serine/Threonine Kinases (STKs), Yank1 or STK32A subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily contains uncharacterized STKs with similarity to the human protein designated Yank1 or STK32A.
Statistics
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PSSM-Id: 173669
View PSSM: cd05578
Aligned: 12 rows
Threshold Bit Score: 383.975
Threshold Setting Gi: 3218400
Created: 4-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #####   #            # #                               #               ##
Q8WU08        22 HFEILRAIGKGSFGKVCIVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 101 human
CAA19590      29 QFKIRNVIGKGSWSTVFVVKHrqtKQRFALKCINKKKHde-hkIKKLRNEVLLLQSLnHPLLCKFYSEFEDetKIYLVTD 107 fission yeast
NP_001020782  22 HFEILRAIGKGSFGKVCVVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 101 chicken
AAH72876      22 HFEILRAIGKGSFGKVCIVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 101 African clawed ...
XP_568881     21 HFYLLRSVGKGAFGKVRVVQHkhtKTLFALKYINKQKCvkmraVANIVQERRLLEEIdHPFVVNLRYAFQDdeNCFFVLD 100 Cryptococcus ne...
NP_499294     27 HFSVIRSIGRGAFGKVCIVQErktKKYFALKYMNKRRCiekgvAANVIRELTLLSKMsHPFIVNLWYTFQDgdYMYMVSD 106 nematode
XP_503305     63 NYELLQVVGSGAFSKVRVVRQmttNNVYALKYSVREDIvklgrTQLMLNERRILLRLqHPFLCNLHQTFCDseYLYTLLD 142 Yarrowia lipoly...
AAK69536      18 HFRLLRVVGRGAFGKVRIVERrdtGLTFALKYIRKGDVirtesVRNILRERRMLEQLnYQFICNLRYSFQDieYMYLVVD 97  grass mildew
XP_796535     22 HFQILRAIGKGSFGKVCIVQKrdtKKMYAMKYMNKAMCirkdaVRNVLREQEILQALeHPFLVNLWFTFQDeeDMFMVVD 101 purple urchin
EAR95457      57 GYIFNQVIGKGGFGKVWNVQKrknKEVLAMKIMSKVKIlskksVNSVLNERKILSHLnHPLIVNMHNSFQDreNLYLTMD 136 Tetrahymena the...
CAK86778     219 HFIYNYVIGKGGFGKVWKVELkknRQMFAMKEMMKSKIiakrsINSVMNEKELLSQLrHPFLVNMCYAFQDrdNLYLIMD 298 Paramecium tetr...
CAA73580      33 HFLLQYIIGVGGFGRVWKVSYk--QQVFAMKEISKALVllkqsVQSIMNELQFLTELrHNLLVNVFSAFQDnqNLYLVLD 110 Paramecium prim...
Feature 1         #   # #                                     # # ## #         ##  #             
Q8WU08       102 LLlGGDLRYHLQQn-vHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDehGHVHITDFNIAAMLPRet----- 175 human
CAA19590     108 LMlGGDLRYHISQr--KFNESVIRIWMVELVSALIYIHSKGVLHRDVKPDNILLDekGHCKLADFNVAAKVHTssspsks 185 fission yeast
NP_001020782 102 LLlGGDLRYHLQQk-vRFQEGTVKLFICELVLALDYLQSRHIIHRDIKPDNILLDehGHVHITDFNIATMLTKet----- 175 chicken
AAH72876     102 LLlGGDLRYHLQQn-vRFTEASVKLYICELALALDYLQSKSIIHRDIKPDNVLLDeqGHVHITDFNIATLVSKgt----- 175 African clawed ...
XP_568881    101 LMlGGDLRFHLDRa-gAMSEEIVRFYVAEIALAIDYLHSKRIVHRDLKPDNILLDekGHAHITDFNIAVHFSDrr----- 174 Cryptococcus ne...
NP_499294    107 LLlGGDLRYHLSQq-gKFAEDRAKLYLCEICLAVEYLHEMKIVHRDIKPENILLDeqGHAHLTDLNLATQLEDdq----- 180 nematode
XP_503305    143 LMtGGDLRWHIERk--TFSEATIRFWVVEVACAVAYLHEKGVVHRDIKPDNIMLDelGHARLGDFNVACMLPYge----- 215 Yarrowia lipoly...
AAK69536      98 LMnGGDLRFHISRk--VFTEEAVRFWISELGLAIRYIHSQGIIHRDIKPDNVLLDaeGHVHLADFNVASDFTPgk----- 170 grass mildew
XP_796535    102 LLlGGDLRYHILQg-vKFDAERVKLYLCEITLALDYLRTHLIIHRDIKPDNILLDedGHVHITDFNIATIVKAnv----- 175 purple urchin
EAR95457     137 FIgGGDLRYHLIHqtePFSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDesGYLKVTDFGISRIWKPd------ 210 Tetrahymena the...
CAK86778     299 LLtGGDLRYHIGKm-kRFKEHQTKFFIACIVSGLEYLHNNNIIHRDIKPENIVLDkrGYARITDLGIARKVRPd------ 371 Paramecium tetr...
CAA73580     111 YLgGGDLRFHLGKl-rKFTEEQTKFFAACIIVGLEYLHEKNIIHRDIKPENLILDnqGYVRITDLGVAIKKTGq------ 183 Paramecium prim...
Feature 1             ######                               #     #  #                            
Q8WU08       176 -qITTMAGTKPYMAPEMFSSrkga--gysFAVDWWSLGVTAYELLRGRRPYHIRSst-sSKEIVHTFEt----TVVTYPS 247 human
CAA19590     186 nmTVGRVGTPVYMAPETLIHav-----syKESDWWSLGITFYECLFQVRPFPNHLl---INWIRASEEekassADRLSSA 257 fission yeast
NP_001020782 176 -qVTTIAGTKPYMAPEMFNStkpi--gysFAVDWWSLGITAYELLRARRPYHIHSnt-pTNEIAHVFKt----ATVMYPA 247 chicken
AAH72876     176 -kITTVAGTKPYMAPEMFCPrgqi--cysFAVDWWSLGVTAYELLRGRRPFHIHSst-aATDIVHVFHt----ATVTYPP 247 African clawed ...
XP_568881    175 -lLTGVAGSMAYMAPEVLTKrg-----ysAPVDFWSLGILAYELLFGKRPFRGRT----NSGLTNSIL-----NEPLSWP 239 Cryptococcus ne...
NP_499294    181 -lATSYSGTRPYMAPEIYATyleiedgydSRVDWWALGVCFYEMLRGRTPFEFSSrtkpEEAYVAFRE-----SSIPYPA 254 nematode
XP_503305    216 ykTDSGCGTIGYMAPEVVRAky------nHLVDWWSLGAVFYECLYGTVPYRYHS----TDEYRRMKLk---eHSNLFPV 282 Yarrowia lipoly...
AAK69536     171 -lLTSKSGTLAYLAPEVYKGkg-----ysSSVDWWSLGVLFYECIYNKRPFEKISs---SDLQEQILK-----ADPKFPV 236 grass mildew
XP_796535    176 -yGTSMSGTKPYMAPEIFQTatddckgysYPVDWWSLGVCAYEMLRTKRPYDIHAns-sIADIQHLFSt----NTVHYPS 249 purple urchin
EAR95457     211 -nSNETSGTPGYIAPEILMRqn-----ygVAVDYYALGIIMYEMAMGKRPYKAKDrkelREQILAKQVq---iKREEIPK 281 Tetrahymena the...
CAK86778     372 -nSQDTSGTPGYMAPEVMCRqn-----hgIAVDYFALGVIAYEFMIGKRPYNGKSrkeiRDQILAKQAs---iKKEDLPN 442 Paramecium tetr...
CAA73580     184 --NFETSGTPGYMAPEVIFRqd-----hgVAVDFFALGVICYEFMTGRRPYYGNRre-iREQIIAKQV-----QIQTSSE 250 Paramecium prim...
Feature 1                                                          
Q8WU08       248 AWs----------QEMVSLLKKLLEPNPDQRFSq------lSDVQNFPYM 281 human
CAA19590     258 LHisrdkklttisKDARSAVMAFLEMDIKKRLGhs-----sKKLQTHPFF 302 fission yeast
NP_001020782 248 AWs----------EEMVMLIKKLLETNPDKRFSq------lKDIQDFPYL 281 chicken
AAH72876     248 AWs----------KEIVSLLHKLLDRNTEERFSs------lETIQDFPYL 281 African clawed frog
XP_568881    240 EDapg-----rcsSDGMHAIRGFLERDPNKRLGyrpggggmDDIKNHPWF 284 Cryptococcus neoformans var. neoformans JEC21
NP_499294    255 HWp----------TDLIQFINSMLKFDKEKRLVg------lEAIKKHSYT 288 nematode
XP_503305    283 TQpq-------vsMAAIEALDLLLTVEAQYRLHd------vDQLLQLSYF 319 Yarrowia lipolytica CLIB122
AAK69536     237 TDpp-------vsIVCMHAISSALEQDPNKRMGctkd-egfSSFTDNPFF 278 grass mildew
XP_796535    250 TWn----------PSLTDLIRQLLSVDPRERISd------lESLSKHPFM 283 purple urchin
EAR95457     282 GWs----------LEAIDFINRLIQRKPSNRLGvn----gpQEVKDHVWI 317 Tetrahymena thermophila SB210
CAK86778     443 GWs----------IEAMDFVNKLLQRKPQNRLGfn----gpSDVKNHPWL 478 Paramecium tetraurelia
CAA73580     251 GWs----------TESIDFINLLLQRKPQNRLMnpr---qhKWFKNFPFD 287 Paramecium primaurelia

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