2R5T


Conserved Protein Domain Family
STKc_SGK

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cd05575: STKc_SGK (this model, PSSM-Id:173666 is obsolete and has been replaced by 270727)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
Serine/Threonine Kinases (STKs), Serum- and Glucocorticoid-induced Kinase (SGK) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis.
Statistics
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PSSM-Id: 173666
Aligned: 7 rows
Threshold Bit Score: 611.794
Created: 23-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ## #### #            # #                                #                # #  
2R5T_A        44 KVIGKGSFGKVLLARHKaeeVFYAVKVLQKKAILKKKeeKHIMSERNVLLKNvkHPFLVGLHFSFQTadKLYFVLDYInG 123 human
CAJ55247     139 TTIGKGSFGRVYQVRHKetkKIYAMKILSKEHIRKKNevKHVMAERNVLINNfkHPFLVSLHFSFQNkeKLYFVLDHLnG 218 nematode
XP_781971     57 KVIGKGSFGKVLLAKHKidgKVYAVKVLQKAAIVKRNeaKHIMAERSVLLKNlkHPFLVSLHYSFQTadKLYFVLDYVnG 136 purple urchin
XP_001629863  78 KVIGKGSFGKVFLSKNKqedKFYAIKVLNKSAIRKRNeaKHIMAERNVLVQNvtHPFLVGLHYSFQTkdKLYFVLDYVnG 157 starlet sea ane...
Q8R4V0       166 KVIGKGSFGKVLLAKRKldgKFYAVKVLQKKIVLNRKeqKHIMAERNVLLKNvkHPFLVGLHYSFQTteKLYFVLDFVnG 245 Norway rat
NP_057360     99 KVIGKGNYGKVLLAKRKsdgAFYAVKVLQKKSILKKKeqSHIMAERSVLLKNvrHPFLVGLRYSFQTpeKLYFVLDYVnG 178 human
O00141       102 KVIGKGSFGKVLLARHKaeeVFYAVKVLQKKAILKKKeeKHIMSERNVLLKNvkHPFLVGLHFSFQTadKLYFVLDYInG 181 human
Feature 1         # #                                    # # ## #         ##  #             #####
2R5T_A       124 GELFYHLQRercFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDsqGHIVLTDFGLCKENIEHNSTTSTFCGTP 203 human
CAJ55247     219 GELFSHLQRekhFSESRSRFYAAEIACALGYLHEKNIIYRDLKPENLLLDdkGYLVLTDFGLCKEDMQGSKTTSTFCGTP 298 nematode
XP_781971    137 GELFFHLQReksFPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILLDhdGHVRLTDFGLCKEGIAAKKTTSTFCGTP 216 purple urchin
XP_001629863 158 GELFFHLQReryFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDskGHIVLTDFGLCKEGIDRSGTTSTFCGTP 237 starlet sea ane...
Q8R4V0       246 GELFFHLQRersFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDsmGHVVLTDFGLCKEGIAISDTTTTFCGTP 325 Norway rat
NP_057360    179 GELFFHLQRerrFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDcqGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258 human
O00141       182 GELFYHLQRercFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDsqGHIVLTDFGLCKENIEHNSTTSTFCGTP 261 human
Feature 1        #                          #     #  #                                           
2R5T_A       204 EYLAPEVLHKqpyDRTVDWWCLGAVLYEMLYGLPPFYSRntAEMYDNILNKPLQLKPNi-tNSARHLLEGLLQkdRTKRL 282 human
CAJ55247     299 EYLAPEIILKkpyDKTVDWWCLGSVLYEMIFGLPPFYSKdhNEMYDKIINQPLRLKHNi-sVPCSELITGLLQkdRSKRL 377 nematode
XP_781971    217 EYLAPEVLRKqeyDRSVDWWCLGAVLFEMMSGLPPFYSRdtAEMYDNILNKPLRMRSSvfsPSAKGLLEGLLHkeRAKRL 296 purple urchin
XP_001629863 238 EYLAPEVLRKqdyDKSVDWWCLGAVLYEMMYGLPPFYSRdtAEMYDNILHKPLRLRTNi-sQSARHILEGLLQkdKTKRL 316 starlet sea ane...
Q8R4V0       326 EYLAPEVIRKqpyDRTVDWWCLGAVLYEMLYGLPPFYCRdvAEMYDNILHKPLNLRPGv-sLTAWSILEELLEknRQNRL 404 Norway rat
NP_057360    259 EYLAPEVLRKepyDRAVDWWCLGAVLYEMLHGLPPFYSQdvSQMYENILHQPLQIPGGr-tVAACDLLQSLLHkdQRQRL 337 human
O00141       262 EYLAPEVLHKqpyDRTVDWWCLGAVLYEMLYGLPPFYSRntAEMYDNILNKPLQLKPNi-tNSARHLLEGLLQkdRTKRL 340 human
Feature 1                                                                                        
2R5T_A       283 Gak-ddFMEIKSHVFFSLINWDDLINKKITPPFNPnvsgpndlrHFDPEFTEEPVPNAIgkapdsvlvtasvkeaaeaFL 361 human
CAJ55247     378 Ghr-ndFRDIRDHPFFLPVDWDKLLNRELKAPFIPkvknamdtsNISKEFVEIQIDPSSlapqqla-----vthrdhdFE 451 nematode
XP_781971    297 GagdkgFKAVKHHEFFSSISWSDLDGKKITPPYNPrvsdsmdvkNIDPEFVREPVPNSVgksvdpntvsasvqdadnvFE 376 purple urchin
XP_001629863 317 GsgegdFEDIRTHSFFRSINWQQLVARGIEPPYNPnvsgqldlkHFDPEFVREPVPGSVgksadsnfvsasvddpddaFV 396 starlet sea ane...
Q8R4V0       405 Gak-edFLEIQNHPFFESLSWTDLVQKKIPPPFNPnvagpddirNFDAVFTEETVPYSVcvssdysivnasvleaddaFV 483 Norway rat
NP_057360    338 Gsk-adFLEIKNHVFFSPINWDDLYHKRLTPPFNPnvtgpadlkHFDPEFTQEAVSKSIgctpdtva---sssgassaFL 413 human
O00141       341 Gak-ddFMEIKSHVFFSLINWDDLINKKITPPFNPnvsgpndlrHFDPEFTEEPVPNSIgkspdsvlvtasvkeaaeaFL 419 human
Feature 1             
2R5T_A       362 GFSYA 366 human
CAJ55247     452 NFTFV 456 nematode
XP_781971    377 GFTYV 381 purple urchin
XP_001629863 397 GFTYV 401 starlet sea anemone
Q8R4V0       484 GFSYA 488 Norway rat
NP_057360    414 GFSYA 418 human
O00141       420 GFSYA 424 human

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