2F2U,2ESM,2VD5


Conserved Protein Domain Family
STKc_ROCK_NDR_like

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cd05573: STKc_ROCK_NDR_like (this model, PSSM-Id:173664 is obsolete and has been replaced by 270725)
Click on image for an interactive view with Cn3D
Catalytic domain of ROCK- and NDR kinase-like Protein Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Rho-associated coiled-coil containing protein kinase (ROCK) and Nuclear Dbf2-Related (NDR)-like kinase subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ROCK- and NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis.
Statistics
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PSSM-Id: 173664
Aligned: 17 rows
Threshold Bit Score: 464.462
Threshold Setting Gi: 47156963
Created: 4-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #####   #              # #                                              
2F2U_B      75 EDYDVVKVIGRGAFGEVQLVRHka--sqKVYAMKLLSKFEMikrsDSAFFWEERDIMAFAn------------------- 133  cattle
Q09898     206 GDFQTITQVGQGGYGSVWLARKrd--tkEIVALKIMNKSVLhkmdEIRHVLTERDILTTAn------------------- 264  Schizosaccharomy...
O95835     703 SMFVKIKTLGIGAFGEVCLARKvd--tkALYATKTLRKKDVllrnQVAHVKAERDILAEAd------------------- 761  human
2ESM_A      74 EDYEVVKVIGRGAFGEVQLVRHks--trKVYAMKLLSKFEMikrsDSAFFWEERDIMAFAn------------------- 132  human
XP_965970   43 SDYEIVKNVAKGGYGEVFLVRRe-----KIYAMKRVSKELVlkqpHTALFMAEKEAMVDCi------------------- 98   Encephalitozoon ...
AAT12343    49 DDFEIVGLLARGAYGEVFVARRs----dAVYAIKRVLKETAvqqpFTALFMAEKELMVDAr------------------- 105  Antonospora locu...
AAZ12641    67 DDFVLVKRIGKGAFGEVYLCYKkydndkQLYALKRMRKTDMirkkQISHVRSEKDVMAEAas------------------ 128  Trypanosoma brucei
AAA19808    52 NEFCVGDAIGRGAFAEVFQCWRpee-phIVYAMKKIRKDLIvkrkQSLNVHTERDLLSDAklrq---------------- 114  Trypanosoma brucei
XP_627966  146 DDFHTISVIGQGGYSIVRLVFDih--tgNVYALKQAKKCQImn-nQSQHDNLENLVKIDInsskkqveekqtlntgimln 222  Cryptosporidium ...
XP_758888  715 NSFLKLKTIGHGAFGVVALCKErq--sgQLYAMKQLRKADMlrkgQEGHVRAERDLMTSAsas----------------- 775  Ustilago maydis 521
Feature 1                    #               ## #   # #                                     # #
2F2U_B     134 ----------SPWVVQLFCAFQDdkYLYMVMEYMpGGDLVNLMSNy-DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVK 201  cattle
Q09898     265 ----------SEWLVRLLYAFQDtsNIYLAMEFVpGGDFRTLLSNsgVLRDHHAKFYATEMFLAIDALHQ-LGYIHRDLK 333  Schizosaccharomy...
O95835     762 ----------NEWVVRLYYSFQDkdNLYFVMDYIpGGDMMSLLIRmgIFPESLARFYIAELTCAVESVHK-MGFIHRDIK 830  human
2ESM_A     133 ----------SPWVVQLFYAFQDdrYLYMVMEYMpGGDLVNLMSNy-DVPEKWARFYTAEVVLALDAIHS-MGFIHRDVK 200  human
XP_965970   99 ---------gSEWLVCAHMTMQDeeYLYYLMDFIpGGDFMGLLSKedVLEEDWVRFYAAEIVAALDELHK-LGWIHRDLK 168  Encephalitozoon ...
AAT12343   106 ---------gSMWLLHAHWTFQDeeAVYYVTDFLpGGDFMGYLVRqeCVTEHEVRFYGAEIVAALEELHG-LGYVHRDLK 175  Antonospora locu...
AAZ12641   129 ---------tNPWVVKLYLSFQDeqYLYMVMEYMpGGDMISWLCIkqRFDVESTRFYIAELCAAVASVHD-MFFVHRDIK 198  Trypanosoma brucei
AAA19808   115 ------krvsCPWITDLVVAFQDqdFLYIVTEYCsGGDLISWLIRydVFPEETARFYFVELVLALNALHK-MGYVRRDVK 187  Trypanosoma brucei
XP_627966  223 teislmynsdSPWINKLYYYWEDnhFYYMLMEYMpGGDLMRHLIDlhTFDEETAKFYIAELLLALDYLNNiQGHIHRDIK 302  Cryptosporidium ...
XP_758888  776 --------atAKWIVKLIYSFQDvdHLYLIMEFMgGGDLLNLLIEkdIFEEDFARFYVAEMVLAIHEAHS-FGYIHRDIK 846  Ustilago maydis 521
Feature 1       ## #         ##  #                                                             
2F2U_B     202 PDNMLLDkhGHLKLADFGTCMKMDEtg----------------------------------------------------- 228  cattle
Q09898     334 PENFLVGasGHIKLTDFGLSSGIISkkkiesmkirlqevnnvvvp----------------------------------- 378  Schizosaccharomy...
O95835     831 PDNILIDrdGHIKLTDFGLCTGFRWthdskyyqsgdhprqdsmdfsnewg------------------------------ 880  human
2ESM_A     201 PDNMLLDksGHLKLADFGTCMKMNKeg----------------------------------------------------- 227  human
XP_965970  169 PDNVLIGidGHVKLADFGSCIKMKDgk----------------------------------------------------- 195  Encephalitozoon ...
AAT12343   176 PENMLIDakGHIRLADFGSCARMADgs----------------------------------------------------- 202  Antonospora locu...
AAZ12641   199 PDNILLDakGHIKLTDFGLSKRFAKvgeelldleegndalcssnssanlsntcgstcqgpn-------------svpvvs 265  Trypanosoma brucei
AAA19808   188 PDNVLIDreGHVKLADFGLSKRDPDqaestsvaddsyltedvt------------------------------------- 230  Trypanosoma brucei
XP_627966  303 PDNILLDvdGHIKLIDFGLSKQIIQskqrpfvsnasvnssf--------------------------------------- 343  Cryptosporidium ...
XP_758888  847 PDNFLYTsdGHIKLADFGLCQSFHWahdgayydqqrknllkkhgidlddshaaagmrraaqatgrrggapgqagaglsdk 926  Ustilago maydis 521
Feature 1                                       ######                              #     #  # 
2F2U_B     229 ---------------------------mvHCDTAVGTPDYISPEVLKSqggdgyYGRECDWWSVGVFLFEMLVGDTPFYA 281  cattle
Q09898     379 ---------ersmrerrqvfrtllsqdpvYAHSVVGSPDYMAPEVLRGe----nYNHSVDYWSLGCIMYECLSGFPPFSG 445  Schizosaccharomy...
O95835     881 ----dpsscrcgdrlkplerraarqhqrcLAHSLVGTPNYIAPEVLLRt----gYTQLCDWWSVGVILFEMLVGQPPFLA 952  human
2ESM_A     228 ---------------------------mvRCDTAVGTPDYISPEVLKSqggdgyYGRECDWWSVGVFLYEMLVGDTPFYA 280  human
XP_965970  196 ----------------------------aRSSITVGTPDYVSPDVLCSvneeceYGEDVDFWTLGVIIYEMIYGTTPFYS 247  Encephalitozoon ...
AAT12343   203 ----------------------------vRCRATVGTPDYVSPEVLCGtgceveYGCEVDLWALGVVLYEMLYEAPPFYS 254  Antonospora locu...
AAZ12641   266 phnphsptanynsltpagshasahpqarrIFESIVGSPGYIAPEILLRq----rYGVNCDWWSVGVIMYEMLYGIPPFFS 341  Trypanosoma brucei
AAA19808   231 ------------vdddvkkrfrdkkerkvMFFSTVGSPAYIAPEVLIGr----gYDYSCDWWSAGVILYEMIFGYPPFFN 294  Trypanosoma brucei
XP_627966  344 -------------qknvtaridphevlihDQNFHAGTPDYMAPEIHRGe----pYSLCVDLWSVGIILFEMLFGGPPLSD 406  Cryptosporidium ...
XP_758888  927 elieimsdrnadgtpkthvltwreknkkkIAYSVVGTNNYMAPEVLRGl----gYDQACDWWSLGVIVFEMLYGYPPFVS 1002 Ustilago maydis 521
Feature 1                                                                                      
2F2U_B     282 Ds--lVGTYSKIMdhkNSLCFPEdae-------isKHAKNLICAFLTdREVRLGrn------------------------ 328  cattle
Q09898     446 Sn--vNETWSNLKnwrKCFQRPHyddprdlefnwrDDAWDFVCHCITdPKDRFCs------------------------- 498  Schizosaccharomy...
O95835     953 Qt--pLETQMKVInwqTSLHIPPqak-------lsPEASDLIIKLCRgPEDRLGkn------------------------ 999  human
2ESM_A     281 Ds--lVGTYSKIMnhkNSLTFPDdnd-------isKEAKNLICAFLTdREVRLGrn------------------------ 327  human
XP_965970  248 Dt--lMETYRRITr--VEFGFPFkv---------sPELTSLIEGLIAaKDRRMR-------------------------- 288  Encephalitozoon ...
AAT12343   255 Et--lQETYERISs--IDLRLPAhg---------sAEFRDLVVRLLCrREERLS-------------------------- 295  Antonospora locu...
AAZ12641   342 Sd--tSSTCHKIThwrEYLTYPSdrg-------vpPEATDLLRRLMCdQRDRLD-------------------------- 386  Trypanosoma brucei
AAA19808   295 Dn--nTATAKKIIqfkEHLEFPKdqt------tvsKEAIDLISHLIAdSKERYG-------------------------- 340  Trypanosoma brucei
XP_627966  407 PgqnsLITRNKVMnwdKHFYLPSehh------kysPEAMDLICSLVCePSQRIKs------------------------- 455  Cryptosporidium ...
XP_758888 1003 Ks--rHLTRQKILnwkQTLRFPTkpr-------isREGQDFIARLVCeREDRLGstasasvsrpnsylqsarrsgfgnqg 1073 Ustilago maydis 521
Feature 1                                                                                      
2F2U_B     329 ----------gVEEIKQHPFFKNDQWNWdniretAAPVVPELSSDIDSSNFddieddkgdve------------------ 380  cattle
Q09898     499 -----------LKQVMQHPYFSKIDWKNvrt-ayRPPFVPDLNSEIDAGYFddftnendmskykevhe---------kqa 557  Schizosaccharomy...
O95835    1000 ----------gADEIKAHPFFKTIDFSSdlr-qqSASYIPKITHPTDTSNFdpvdpdklwsddneee----------nvn 1058 human
2ESM_A     328 ----------gVEEIKRHLFFKNDQWAWetlrdtVAPVVPDLSSDIDTSNFddleedkgeee------------------ 379  human
XP_965970  289 -----------IEEIKSHAFFEGVDWSRlk--elKPPFVPEVNGDSDTSHFvdtqfdaek-------------------- 335  Encephalitozoon ...
AAT12343   296 -----------LEDVKAHAFFAGTDWESlh--rrQSPFVPKVMGDADMSNFerategstlae------------------ 344  Antonospora locu...
AAZ12641   387 -----------FQGVKEHPFFNDIDWERlr--etPPAFVPELSDPLDTHYFpevedntpqqhhqr--------------- 438  Trypanosoma brucei
AAA19808   341 -----------FEEIIRHPFCKGVPLTDsir-neEAPFSVVLNDPKDLQYFepapdnadiqk------------------ 390  Trypanosoma brucei
XP_627966  456 -----------AKEALKHPFFKGMDFTKir--hqKPPIVPKVKHKLDHSNFdkfpddllvsfynsakastsv-pisnlse 521  Cryptosporidium ...
XP_758888 1074 qsntgsalqdgVEELMSHPWFRGIDWENlh--rtRPPFRPALSHPGDTKHFeddiedeplaapgaannpnadqprdpmlr 1151 Ustilago maydis 521
Feature 1                             
2F2U_B     381 --tfpipkafvgnQLPFIGFTYY 401  cattle
Q09898     558 aianmvntfnkpkRNAFIGFTFR 580  Schizosaccharomyces pombe
O95835    1059 dtlngwykngkhpEHAFYEFTFR 1081 human
2ESM_A     380 --tfpipkafvgnQLPFVGFTYY 400  human
XP_965970  336 -----rklnvkgnYMPFVGFTFD 353  Encephalitozoon cuniculi GB-M1
AAT12343   345 ---secgrggdahFLNFVGFTFD 364  Antonospora locustae
AAZ12641   439 peernavrevdprGVIFADYKFN 461  Trypanosoma brucei
AAA19808   391 ---qpmtavsredQSVFVGFTSK 410  Trypanosoma brucei
XP_627966  522 elnfnscntnkiqGESFVSEFFP 544  Cryptosporidium parvum Iowa II
XP_758888 1152 dqeqgpkllemrkQLAFMGYTFK 1174 Ustilago maydis 521

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