1O6K,2JDO,1MRY


Conserved Protein Domain Family
STKc_PKB

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cd05571: STKc_PKB (this model, PSSM-Id:173662 is obsolete and has been replaced by 270723)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase B
Serine/Threonine Kinases (STKs), Protein Kinase B (PKB) or Akt subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of PI3K and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis.
Statistics
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PSSM-Id: 173662
Aligned: 8 rows
Threshold Bit Score: 660.351
Threshold Setting Gi: 74962554
Created: 24-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1O6K_A; Human PKB-beta binds AMP-PNP and GSK3 peptide substrate; defined at 4A contacts.
    View structure with Cn3D
  • Structure:2JDO_A; Human PKB-beta binds inhibitor and GSK3 peptide substrate; defined at 4A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       ## ##   #            # #           #  #                #               ####   
1O6K_A     11 KLLGKGTFGKVILVREKatgRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTrHPFLTALKYAFQThdRLCFVMEYAnGG 90  human
Q01314    154 KLLGKGTFGKVILVKEKatgRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSrHPFLTALKYSFQThdRLCFVMEYAnGG 233 cattle
Q9WUA6    152 KLLGKGTFGKVILVREKasgKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTrHPFLTSLKYSFQTkdRLCFVMEYVnGG 231 house mouse
2JDO_A     16 KLLGKGTFGKVILVREKatgRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTrHPFLTALKYAFQThdRLCFVMEYAnGG 95  human
1MRY_A     14 KLLGKGTFGKVILVREKatgRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTrHPFLTALKYAFQThdRLCFVMEYAnGG 93  human
Q17941    197 KVLGKGTFGKVILCKEKrtqKLYAIKILKKDVIIAREEVAHTLTENRVLQRCkHPFLTELKYSFQEqhYLCFVMQFAnGG 276 nematode
Q8INB9    270 KVLGKGTFGKVILCREKataKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTnHPFLISLKYSFQTndRLCFVMQYVnGG 349 fruit fly
BAB69974  162 KMLGKGTFGKVLLVREKtggELYAIKILKKAVIVAKDEVAHTLTESHVLQRTcHPFLTSLKYSFQTtdRLCFVMEYVnGG 241 Patiria pectinifera
Feature 1     # #   #                                 # # ## #         ##  #             #####
1O6K_A     91 ELFFHLSRervFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDkdGHIKITDFGLCKEGISDGATMKXFCGTP 169 human
Q01314    234 ELFFHLSRervFSEDRARFYGAEIVSALDYLHSeKEVVYRDLKLENLMLDkdGHIKITDFGLCKEGIKDGATMKTFCGTP 313 cattle
Q9WUA6    232 ELFFHLSRervFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDkdGHIKITDFGLCKEGITDAATMKTFCGTP 310 house mouse
2JDO_A     96 ELFFHLSRervFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDkdGHIKITDFGLCKEGISDGATMKXFCGTP 174 human
1MRY_A     94 ELFFHLSRervFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDkdGHIKITDFGLCKEGISDGATMKTFCGTP 172 human
Q17941    277 ELFTHVRKcgtFSEPRARFYGAEIVLALGYLHR-CDIVYRDMKLENLLLDkdGHIKIADFGLCKEEISFGDKTSTFCGTP 355 nematode
Q8INB9    350 ELFWHLSHeriFTEDRTRFYGAEIISALGYLHS-QGIIYRDLKLENLLLDkdGHIKVADFGLCKEDITYGRTTKTFCGTP 428 fruit fly
BAB69974  242 ELFFHLSRervFSEDRTRFYGAEIISALTYLHE-CNVIYRDLKLENLLLDqfGHIKITDFGLCKEDLSYGNTTSTFCGTP 320 Patiria pectinifera
Feature 1     ###                        #     #  #                                           
1O6K_A    170 EYLAPEVLEDNdyGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTlsPEAKSLLAGLLKkDPKQRLG 249 human
Q01314    314 EYLAPEVLEDNdyGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTlsPEAKSLLSGLLKkDPKQRLG 393 cattle
Q9WUA6    311 EYLAPEVLEDNdyGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTlsSDAKSLLSGLLIkDPNKRLG 390 house mouse
2JDO_A    175 EYLAPEVLEDNdyGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTlsPEAKSLLAGLLKkDPKQRLG 254 human
1MRY_A    173 EYLAPEVLEDNdyGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTlsPEAKSLLAGLLKkDPKQRLG 252 human
Q17941    356 EYLAPEVLDDHdyGRCVDWWGVGVVMYEMMCGRLPFYSKDHNKLFELIMAGDLRFPSKlsQEARTLLTGLLVkDPTQRLG 435 nematode
Q8INB9    429 EYLAPEVLDDNdyGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNitDEAKNLLAGLLAkDPKKRLG 508 fruit fly
BAB69974  321 EYLAPEVLEDSdyGRAVDWWGTGVVMYEMMCGRLPFYSRDHEVLFELILVEEVKFPARlsESARSLLTGLLAkDPTKRLG 400 Patiria pectinifera
Feature 1                                                 #   #                               
1O6K_A    250 GGpsdAKEVMEHRFFLSINWQDvvqkkllPPFKPQVTSEVDTRYFDDEFTAQSITITPPdrydslgl---leldqrthFP 326 human
Q01314    394 GGsedAKEIMQHRFFASIVWQDvyekklsPPFKPQVTSETDTRYFDEEFTAQMITITPPdqddsmeg---vdserrphFP 470 cattle
Q9WUA6    391 GGpddAKEIMRHSFFSGVNWQDvydkklvPPFKPQVTSETDTRYFDEEFTAQTITITPPekydddgmd-gmdnerrphFP 469 house mouse
2JDO_A    255 GGpsdAKEVMEHRFFLSINWQDvvqkkllPPFKPQVTSEVDTRYFDDEFTAQSITITPPdrydslglleldqreeqemFE 334 human
1MRY_A    253 GGpsdAKEVMEHRFFLSINWQDvvqkkllPPFKPQVTSEVDTRYFDDEFTAQSITITPPdrydslgl---leldqrthFP 329 human
Q17941    436 GGpedALEICRADFFRTVDWEAtyrkeiePPYKPNVQSETDTSYFDNEFTSQPVQLTPPsrsgalatv-deqeemqsnFT 514 nematode
Q8INB9    509 GGkddVKEIQAHPFFASINWTDlvlkkipPPFKPQVTSDTDTRYFDKEFTGESVELTPPdptgplg-----siaeeplFP 583 fruit fly
BAB69974  401 GGqedAKEIMEHPFFACINWEDlfnkkiePPFKPSVKSDTDTRYFDEEFTAEPVELTPPddnklst------dsglpqFE 474 Patiria pectinifera
Feature 1            
1O6K_A    327 QFDYSAS 333 human
Q01314    471 QFSYSAS 477 cattle
Q9WUA6    470 QFSYSAS 476 house mouse
2JDO_A    335 DFDYIAD 341 human
1MRY_A    330 QFSYSAS 336 human
Q17941    515 QFSFHNV 521 nematode
Q8INB9    584 QFSYQGD 590 fruit fly
BAB69974  475 KFSYSGD 481 Patiria pectinifera

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