1ZRZ,1XJD,2I0E


Conserved Protein Domain Family
STKc_PKC

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cd05570: STKc_PKC (this model, PSSM-Id:173661 is obsolete and has been replaced by 270722)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase C
Serine/Threonine Kinases (STKs), Protein Kinase C (PKC) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs.
Statistics
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PSSM-Id: 173661
View PSSM: cd05570
Aligned: 8 rows
Threshold Bit Score: 560.458
Threshold Setting Gi: 6225859
Created: 23-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the binding of peptide substrates and ATP analogs to the AGC kinases, PKA and PKB.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #####   #            # #                                  #               ## #
1ZRZ_A     26 RVIGRGSYAKVLLVRLkktdRIYAMKVVKKelvnddediDWVQTEKHVFEQAs--nHPFLVGLHSCFQTesRLFFVIEYV 103  human
1XJD_A     23 KMLGKGSFGKVFLAEFkktnQFFAIKALKKdvvlmdddvECTMVEKRVLSLAw--eHPFLTHMFCTFQTkeNLFFVMEYL 100  human
2I0E_A     26 MVLGKGSFGKVMLSERkgtdELYAVKILKKdvviqdddvECTMVEKRVLALPg--kPPFLTQLHSCFQTmdRLYFVMEYV 103  human
Q16513    661 AVLGRGHFGKVLLAEYkntnEMFAIKALKKgdivardevDSLMCEKRIFETVnsvrHPFLVNLFACFQTkeHVCFVMEYA 740  human
AAI09034  412 KVLGKGSFGKVMLAELkgkdEVYAVKVLKKdvilqdddvDCTMTEKRILALAr--kHPYLTQLYCCFQTkdRLFFVMEYV 489  human
P13677    375 KVIGKGSFGKVLLAERrgtdELYAVKVLRKdviiqtddmELPMNEKKILALSg--rPPFLVSMHSCFQTmdRLFFVMEYC 452  fruit fly
CAA73553  347 VVLGKGSFGKVFLAEQkttkDVYAIKSLKKdlivqeddvECTLNERKVLALQe--kPPFLTGLHSCFQTrdHLFFVMEYI 424  Suberites domuncula
P24723    359 RVLGKGSFGKVMLARVketgDLYAVKVLKKdvilqdddvECTMTEKRILSLAr--nHPFLTQLFCCFQTpdRLFFVMEFV 436  human
Feature 1        # #                                    # # ## #         ##  #             ###
1ZRZ_A    104 nGGDLMFHMQRqrkLPEEHARFYSAEISLALNYLHeRGIIYRDLKLDNVLLDseGHIKLTDYGMCKEGLRPGDTTSXFCG 183  human
1XJD_A    101 nGGDLMYHIQSchkFDLSRATFYAAEIILGLQFLHsKGIVYRDLKLDNILLDkdGHIKIADFGMCKENMLGDAKTNXFCG 180  human
2I0E_A    104 nGGDLMYHIQQvgrFKEPHAVFYAAEIAIGLFFLQsKGIIYRDLKLDNVMLDseGHIKIADFGMCKENIWDGVTTKXFCG 183  human
Q16513    741 aGGDLMMHIHTd-vFSEPRAVFYAACVVLGLQYLHeHKIVYRDLKLDNLLLDteGFVKIADFGLCKEGMGYGDRTSTFCG 819  human
AAI09034  490 nGGDLMFQIQRsrkFDEPRSRFYAAEVTSALMFLHqHGVIYRDLKLDNILLDaeGHCKLADFGMCKEGILNGVTTTTFCG 569  human
P13677    453 kGGDLMYHMQQygrFKESVAIFYAVEVAIALFFLHeRDIIYRDLKLDNILLDgeGHVKLVDFGLSKEGVTERQTTRTFCG 532  fruit fly
CAA73553  425 nGGDLMFHILElgrFPENQTKFYAGEIVLGLRFLHkRGIIYRDLKLDNVMLDadGHIKIADFGLCKEGILGGNKTRTFCG 504  Suberites domuncula
P24723    437 nGGDLMFHIQKsrrFDEARARFYAAEIISALMFLHdKGIIYRDLKLDNVLLDheGHCKLADFGMCKEGICNGVTTATFCG 516  human
Feature 1     ###                          #     #  #                                         
1ZRZ_A    184 TPNYIAPEILRGedyGFSVDWWALGVLMFEMMAGRSPFDIVgssdnpdqnteDYLFQVILEKQIRIPRSmsVKAASVLKS 263  human
1XJD_A    181 TPDYIAPEILLGqkyNHSVDWWSFGVLLYEMLIGQSPFHGQd---------eEELFHSIRMDNPFYPRWleKEAKDLLVK 251  human
2I0E_A    184 TPDYIAPEIIAYqpyGKSVDWWAFGVLLYEMLAGQAPFEGEd---------eDELFQSIMEHNVAYPKSmsKEAVAICKG 254  human
Q16513    820 TPEFLAPEVLTEtsyTRAVDWWGLGVLIYEMLVGESPFPGDd---------eEEVFDSIVNDEVRYPRFlsTEAISIMRR 890  human
AAI09034  570 TPDYIAPEILQEleyGPSVDWWALGVLMYEMMAGQPPFEADn---------eDDLFESILHDDVLYPVWlsKEAVSILKA 640  human
P13677    533 TPNYMAPEIVSYdpySIAADWWSFGVLLFEFMAGQAPFEGDd---------eTTVFRNIKDKKAVFPKHfsVEAMDIITS 603  fruit fly
CAA73553  505 TPDYIAPEIISYqpyDAAVDWWALGVLTYEMLVGRPPFDGDd---------dDQLFNNIMEKPVHYPRGmsDPAKKIIQG 575  Suberites domuncula
P24723    517 TPDYIAPEILQEmlyGPAVDWWAMGVLLYEMLCGHAPFEAEn---------eDDLFEAILNDEVVYPTWlhEDATGILKS 587  human
Feature 1                                                                                     
1ZRZ_A    264 FLNkdPKERLGclpq-tgfADIQGHPFFRNVDWDMmeqKQVVPPFKPnisgefgldNFDSQFTNERVQLXPddddi-vrk 341  human
1XJD_A    252 LFVrePEKRLGv------rGDIRQHPLFREINWEElerKEIDPPFRPkvkspfdcsNFDKEFLNEKPRLSFadral-ins 324  human
2I0E_A    255 LMTkhPGKRLGcgp--egeRDIKEHAFFRYIDWEKlerKEIQPPYKPkacg-rnaeNFDRFFTRHPPVLXPpdqev-irn 330  human
Q16513    891 LLRrnPERRLGase--kdaEDVKKHPFFRLIDWSAlmdKKVKPPFIPtirgredvsNFDDEFTSEAPILTPpreprilse 968  human
AAI09034  641 FMTknPHKRLGcvasqngeDAIKQHPFFKEIDWVLleqKKIKPPFKPriktkrdvnNFDQDFTREEPVLTLvdeai-vkq 719  human
P13677    604 FLTkkPNNRLGagr--yarQEITTHPFFRNVDWDKaeaCEMEPPIKPmikhrkdisNFDDAFTKEKTDLTPtdklf-mmn 680  fruit fly
CAA73553  576 FLTkhPSRRLGchpe-tgeQDIKGAPFFKSIDWDRlgrRELKPPYKPkirgkksvsNFDPEFTKEPCRLSPvdptv-iga 653  Suberites domuncula
P24723    588 FMTknPTMRLGsltq-ggeHAILRHPFFKEIDWAQlnhRQIEPPFRPriksredvsNFDPDFIKEEPVLTPidegh-lpm 665  human
Feature 1                 
1ZRZ_A    342 idQSEFEGFEYI 353  human
1XJD_A    325 mdQNMFRNFXFM 336  human
2I0E_A    331 idQSEFEGFXFV 342  human
Q16513    969 eeQEMFRDFDYI 980  human
AAI09034  720 inQEEFKGFSYF 731  human
P13677    681 ldQNDFIGFSFM 692  fruit fly
CAA73553  654 iePEVFEGFSFT 665  Suberites domuncula
P24723    666 inQDEFRNFSYV 677  human

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