Conserved Protein Domain Family
PTKc_DDR2

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cd05095: PTKc_DDR2 (this model, PSSM-Id:173651 is obsolete and has been replaced by 270677)
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
Protein Tyrosine Kinase (PTK) family; mammalian Discoidin Domain Receptor 2 (DDR2) and homologs; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a member of the DDR subfamily, which are receptor tyr kinases (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens. More recently, it has been reported to also bind collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function.
Statistics
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PSSM-Id: 173651
View PSSM: cd05095
Aligned: 5 rows
Threshold Bit Score: 613.834
Threshold Setting Gi: 47215935
Created: 9-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #####   #                               # #                         
gi 55959764  557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFkdkdfal---dvsanqpVLVAVKMLRADANKnaRNDFLKEIKIMSRLK 633
gi 118094070 559 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFadkeftlegldaspncpVLVAVKMLRADANKnaRNDFLKEIKIMSRLK 638
gi 47216640  554 EFPRKMLTFKEKLGEGQFGEVHLCEAEGMHKFmdkeflf---dvpedqpVLVAVKMLRSDANKnaRSDFLKEIKIMSRLK 630
gi 47215935  549 EFPRDRLSFKEKLGEGQFGEVHLCEAEGLLDFleedlsv---epkgkspLLVAVKTLREDANKnaRNDFLKEIRIMSRLR 625
gi 148725482 526 EFPRDRLTFKEKLGEGQFGEVHLCEAEGMQEFmkdhcd-----dicvdpMLVAVKTLREDADKnaRNDFMKEIRIISRLR 600
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ####  ##                                                    
gi 55959764  634 DPNIIHLLAVCItdDPLCMITEYMENGDLNQFLSRHeppnss---------ssdvrtVSYTNLKFMATQIASGMKYLSSL 704
gi 118094070 639 DPNIIRLLAVCItdDPLCMITEYMENGDLNQFLSRHeaqspp---------dasvptISYSDLRFMATQIASGMKYLSSL 709
gi 47216640  631 DPNIIRLLAVCIcsDPLCMITEYMENGDLNQFLSRHepegqla-------lisnastVSFSNLCYMAAQIASGMKYLSSL 703
gi 47215935  626 DPNIVRLLAVCVdtDPLCMITEYMENGDLNQFLCSLrfkeaaekekrdpdekeekvfTSFSTLISMAVQIASGMKYLSSL 705
gi 148725482 601 DPNIIRLLAVCVesDPLCMITEYMENGDLNQFLSRHqlqedgv--------qadstsISYGTLINMASQISSGMKYLSSL 672
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #   ## #          #                 #####        #                         
gi 55959764  705 NFVHRDLATRNCLVGKnYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLgKFTTASDVWAFGVTLWETFTFC 784
gi 118094070 710 NFVHRDLATRNCLVGKrYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLgKFTTASDVWAFGVTLWETFTLC 789
gi 47216640  704 NFVHRDLATRNCLVGKnFTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLgKFTTASDVWAFGVTLWEILNFC 783
gi 47215935  706 NFVHRDLATRNCLVGRnCTIKIADFGMSRNLYRGDYYRIQGRAVLPIRWMSWESILLgKFTMASDVWAFGVTMWEILTLC 785
gi 148725482 673 NFVHRDLATRNCLVGMnNIIKIADFGMSRNLYRGDYYRIQGRAVLPIRWMSWESILLgKFTMASDVWAFGVTLWEILTLC 752
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                 #                                                          
gi 55959764  785 QEQPYSQLSDEQVIENTGEFFRDqgRQTYLPQPAICP-DSVYKLMLSCWRRdTKNRPSFQEIHLLLLQ 851
gi 118094070 790 REQPYSQLSDEQVIENTGEFFRDqgRQTYLPKPALCP-DSVYKLMLSCWRRdTKDRPSFQDLHRQLQE 856
gi 47216640  784 KEQPYSQLTDEQVIENTGEFFRDqkRQIYLPQPGLCP-DSLYKVMLSCWRRnAKERPSFQEIHTTLLE 850
gi 47215935  786 EEQPYSHLSDEQVIENTGEFFRDqgKQVYLPKPPRCPdRLYNDLMLSCWRRnAKQRPSFQEIHAQLME 853
gi 148725482 753 KEQPYAQFTDEQVIENTGEFFRDqnKQVYLLRPACCP-ESLYSLMLNCWRRnAKERPTFLEIHSTLTE 819

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