Conserved Protein Domain Family
PTKc_Axl

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cd05075: PTKc_Axl (this model, PSSM-Id:173642 is obsolete and has been replaced by 270660)
Catalytic domain of the Protein Tyrosine Kinase, Axl
Protein Tyrosine Kinase (PTK) family; Axl; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is a member of the Axl subfamily, which is composed of receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. Axl signaling is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. Axl is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas.
Statistics
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PSSM-Id: 173642
View PSSM: cd05075
Aligned: 3 rows
Threshold Bit Score: 596.629
Threshold Setting Gi: 47221063
Created: 23-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs including, the structure of human c-Mer tyr kinase bound with the ATP analog, ANP (2P0C_A).
  • Citation:PMID 9312016

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #####   #              # #                              #                 
gi 239938818 536 VALGKTLGEGEFGAVMEGQLNQDdsILKVAVKTMKIAICTRselEDFLSEAVCMKEFDHPNVMRLIGVCFQgseresfPA 615
gi 47221063  485 LTLGKTLGEGEFGSVMEGLLTQEesVLKVAVKTMKIAICTRsemEDFLREAACMKEFDHANVMRLLGVCLQtvesegyPS 564
gi 147904872 514 LALGKTLGEGEFGSVMEGQLNQDdyILKVAVKTMKIAICTRtemEDFLSEAVCMKEFDHPNVMRLIGVCLQntenegyPS 593
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ###   #                                                           #   ## # 
gi 239938818 616 PVVILPFMKHGDLHSFLLYSRLGDqp---------------vYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML 680
gi 47221063  565 PVVILPYMKHGDLHSYLLYSRLGDcpvlgrdtswlqplcpfqYLPSQMLVKFMTDIARGMEYLSSKSFIHRDLAARNCML 644
gi 147904872 594 PVVILPFMKHGDLHSFLLYSRLGDtp---------------lFLPTQTLVKFMTDIASGMAYLSSKNFIHRDLAARNCML 658
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                 #####        #                                 #     
gi 239938818 681 NEnMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADrVYTSKSDVWSFGVTMWEIATRgQTPYPGVENSEIYD 760
gi 47221063  645 NEnMNVCVADFGLSKKIYNGDYYRQGRISKMPVKWIAIESLADrVYTTKSDVWSFGVTMWEIATRgQTPYPGVENSEIYD 724
gi 147904872 659 NEnMNVSVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADrVYTTKSDVWSFGVTMWEIATRgQTPYPGVENSEIYD 738
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
gi 239938818 761 YLRQGNRLKQPADCLDGLYALMSRCWELnPQDRPSFTELREDLENTL 807
gi 47221063  725 YLRQGNRLKQPPDCLDCIYSLMFSCWLLsPKDRPSFETLRCELEKAL 771
gi 147904872 739 YLQQGNRLKQPPDCLDGLYELMSSCWQLnAKDRPCFDTLYRELEKIS 785

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