1Y6B


Conserved Protein Domain Family
PTKc_VEGFR

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cd05054: PTKc_VEGFR (this model, PSSM-Id:173635 is obsolete and has been replaced by 270647)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
Protein Tyrosine Kinase (PTK) family; Vascular Endothelial Growth Factor Receptor (VEGFR) subfamily; catalytic (c) domain. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. VEGFR1 binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow.
Statistics
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PSSM-Id: 173635
View PSSM: cd05054
Aligned: 5 rows
Threshold Bit Score: 634.967
Threshold Setting Gi: 70571445
Created: 17-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #####   #                 ###                #                    
1Y6B_A        21 KWEFPRDRLKLgKPLGRGAFGQVIEADAFGIDktaTCRTVAVKMLKEGathsEHRALMSELKILIHIGHHLNVVNLLGAC 100
gi 70571445  306 KWEFPRDRLRFgKTLGRGAFGKVIQATAFDLEkssSCKTVAVKMLKVGsrsnEYRALMTELRILIHLGPHLNIVNLLGAC 385
gi 72535148  809 KWEFPRDRLKLeKPLGRGAFGRVMQASAVGTGnsaSCTTVAVKMLKDGatpsEHKALMTELKILNHIGHHINVVNLLGAC 888
gi 82105132  811 KWEIARERLKLgKSLGHGAFGKVVQASAFGIKkspTCRIVAVKMLKEGatasEYKALMTELKILIHIGHHLNIVNLLGAC 890
gi 82071567  850 KWEFPRDRLRLgKVLGHGAFGKVVEASAFGINksnSCETVAAKMLKEGatasEQKALMSELKILIHIGNHLNVVNLLGAC 929
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # ##### ##                                                              
1Y6B_A       101 TkpGGPLMVIVEFCKFGNLSTYLRSKRneFVPYKTKGARfrqgkdyv-gaipvdlKRRLDSITSSQSSa--------sSG 171
gi 70571445  386 TtkEGPLMVIVEYCRHGNLSNYLRGLRhcYTGGRNEDTSkqe-----------ikKQRLMSDDSADDGafsgtdetdrSS 454
gi 72535148  889 TksGGPLMVIVEYCQFGNLSAYLKSKRevFLLNRVNKEEegvm--------kegcKGRLTSVSSRQSNa--------sSG 952
gi 82105132  891 TknGGPLMVIVEYCKYGNLSNYLKSKRnfFSPTKDPSLQgelmkdkkgiepvegkKQRLASVTSSESFa--------sSG 962
gi 82071567  930 TkpNGPLMVIVEFCKYGNLSNYLRTKRegFSPYREKSPRlriqv------qsiveAVRADRRSRSGTSdsa-----ifNR 998
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1Y6B_A       172 FVEEKSl-------------------------------------sDVEEEEAP-EDLYKd---FLTLEHLICYSFQVAKG 210
gi 70571445  455 WITDKRgsrasylsgtgsltshegdirshtrlssgcedsrmnlekHHEANDDG-DEKGKeqkdQLTLTDLLSYSLQVARG 533
gi 72535148  953 FSEERGe--------------------------------------ISEEDSYClSELSD----PLLLEDLISYSFQVARG 990
gi 82105132  963 FQEDKSl-------------------------------------sDAEEDEEDaAELYKl---PLTMEDLISYSFQVARG 1002
gi 82071567  999 FLMHKSq--------------------------------------TVQPIQEV-DDLWQs---PLTMEDLICYSFQVARG 1036
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #      # #   ## #         ###                 #####        #                 
1Y6B_A       211 MEFLASRKCIHRDLAARNILLSEkNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDrVYTIQSDVWSFGVL 289
gi 70571445  534 MEFLASKKCIHRDLAARNVLLSDyQVVKICDFGLARDIYKDPDYVRSGgDARLPIKWMAPESIFDkVYSNKSDVWSFGVL 613
gi 72535148  991 MEFLASRKCIHRDLAARNILLSNnNVVKICDFGLARDLYKDPDYVRNG-DARLPLKWMAPESIFDkVFTTQSDVWSYGVL 1069
gi 82105132 1003 MEFLSSRKCIHRDLAARNILLSEnNVVKICDFGLARDIYKNPDYVRKG-DARLPLKWMAPESIFDkIYNTKSDVWSYGVL 1081
gi 82071567 1037 MEFLASRKCIHRDLAARNILLSEnNVVKICDFGLARDIYKDPDYVRKG-SARLPLKWMAPESIFDkVYTTQSDVWSFGVL 1115
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                         #                                                       
1Y6B_A       290 LWEIFSLGASPYPGvkiDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGePSQRPTFSELVEHLGNLLQAN 362
gi 70571445  614 LWEIFTLGGSPYPGlqmDEDFCNKLRRGVRMGKPEHATDSVYSAMLGCWDNnPEDRPTFTKLCEEISDVLQEE 686
gi 72535148 1070 LWEIFSLGASPYPGlnmDEEFCRRLKHGTRMCSPQYSTPEIYSIMCACWENnPEDRPSFTTLVEILGDLLQTC 1142
gi 82105132 1082 LWEIFSLGASPYPGvqiDEDFCSKLKEGTRMRAPEQATEEIYQIMLDCWRSnPNERPWFSELVKRLGDLLQAS 1154
gi 82071567 1116 LWEIFSLGASPYPGvqiNEEFCQRFKDGTRMRAPEYTTAEIYRIMLSCWHGdPKERPTFSDLVEILGNLLQEN 1188

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