3CD3


Conserved Protein Domain Family
PTKc_Fes_like

?
cd05041: PTKc_Fes_like (this model, PSSM-Id:173629 is obsolete and has been replaced by 270637)
Click on image for an interactive view with Cn3D
Catalytic domain of Fes-like Protein Tyrosine Kinases
Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.
Statistics
?
PSSM-Id: 173629
View PSSM: cd05041
Aligned: 6 rows
Threshold Bit Score: 486.585
Threshold Setting Gi: 31746497
Created: 14-Aug-2006
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3CD3_A; Human Fes binds staurosporine and consensus peptide; contacts at 4A.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1        ###     #            # #                 #                            ####  ##
3CD3_A     120 EQIGRGNFGEVFSGRLradnTLVAVKSCRETLpp-dlKAKFLQEARILKQYSHPNIVRLIGVCTqkqPIYIVMELVQGGD 198  human
P18106    1067 ERIGRGNFGDVYKAKLkstkLDVAVKTCRMTLpd-eqKRKFLQEGRILKQYDHPNIVKLIGICVqkqPIMIVMELVLGGS 1145 fruit fly
AAP68901   965 QKIGQGNFGDVYRGVYn--gCEVAVKTCRVDMtasdlRRKFLQGETTALNFNHPNIVKLVGIAVqsyPIMIVMEYVPGGS 1042 Schistosoma mansoni
BAA81721   638 RKLGKGAFGDVWEAALkg-qGKVAVKTCRSTDvp--dREKFLQEAEILKQYDHPNIVKLIGVSWdtePVLIVMELMPGGS 714  Ephydatia fluvia...
AAA61190   567 ELLGKGNFGEVYKGTLkd-kTSVAVKTCKEDLpq-elKIKFLQEAKILKQYDHPNIVKLIGVCTqrqPVYIIMELVSGGD 644  human
CAA76605   624 EKIGKGNFGDVFKGYLkthnMEVAVKSCRSEDfp--dKQKFLQEAEILKQYRHPNIVELIGVCAekePLYIIMELMAGGN 701  Sycon raphanus
Feature 1                                              #   ## #         ##                 ####
3CD3_A     199 FLTFLRTEga-rLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEkNVLKISDFGMSREEAdgVXAASgGLRQV 277  human
P18106    1146 LLTYLRKNsn-gLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLeHSVKISDFGMSREEE--EYIVSdGMKQI 1222 fruit fly
AAP68901  1043 LLNHLRKSkn-aLPVMKLLQMSLDAANGMMYLEARNCIHRDLAARNCLISDdGQLKIADFGMSREEH--IYELSdKRGQI 1119 Schistosoma mansoni
BAA81721   715 LLDYLRKKaa-qMTKGKLLHMSIDACGGMEYLESKNCIHRDLAARNCLVGEnDIVKISDFGMSREEEggMYTVQsGTRQI 793  Ephydatia fluvia...
AAA61190   645 FLTFLRRKkd-eLKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGEnNVLKISDFGMSRQEDggVYSSS-GLKQI 722  human
CAA76605   702 FLSFLRGPegkrLKVNNLTEMCVEAAAGMVFLEQRNCIHRDLAARNCLVGDnNVLKISDFGMSREEDdgIYTVSsGLKQI 781  Sycon raphanus
Feature 1      ## #                                       #   #                                
3CD3_A     278 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLgASPYPNLSNQQTREFVEKGGRLPCPELcPDAVFRLMEQCWAYePG 357  human
P18106    1223 PVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKgDTPYSGMTNSRARERIDTGYRMPTPKStPEEMYRLMLQCWAAdAE 1302 fruit fly
AAP68901  1120 PIKWTAPEALRTGRYTIKCDVWSYGVLLWEIFTFgDVPYRNWSNQQTRDMIESGYRLPAPDLmPVWLRTLMNHCWHDePM 1199 Schistosoma mansoni
BAA81721   794 PIKWTAPEALNYGRYTSASDVWSFGVLLYEVFSGgSTPYPGMSNAETRTQVDSGYRMPPPQGcPAEIHQIMQLCWAYdAE 873  Ephydatia fluvia...
AAA61190   723 PIKWTAPEALNYGRYSSESDVWSFGILLWETFSLgVCPYPGMTNQQAREQVERGYRMSAPQHcPEDISKIMMKCWDYkPE 802  human
CAA76605   782 PIKWTSPEALNYGRYTTQSDVWSYGILLWETYTYgSGPYPGMNNRETRERIESNYRMPRPELcPHPVYKLMLSCWEYdPD 861  Sycon raphanus
Feature 1                    
3CD3_A     358 QRPSFSTIYQELQS 371  human
P18106    1303 SRPHFDEIYNVVDA 1316 fruit fly
AAP68901  1200 NRPSFSKISNEIQI 1213 Schistosoma mansoni
BAA81721   874 DRPKFGAVLESLKK 887  Ephydatia fluviatilis
AAA61190   803 NRPKFSELQKELTI 816  human
CAA76605   862 KRPSFAEIYDKLYS 875  Sycon raphanus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap