1Y57,2DQ7,1QCF,2HK5,1QPJ,3A4O,2SRC


Conserved Protein Domain Family
PTKc_Src_like

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cd05034: PTKc_Src_like (this model, PSSM-Id:173626 is obsolete and has been replaced by 270630)
Click on image for an interactive view with Cn3D
Catalytic domain of Src kinase-like Protein Tyrosine Kinases
Protein Tyrosine Kinase (PTK) family; Src kinase subfamily; catalytic (c) domain. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) proteins are cytoplasmic (or non-receptor) tyr kinases which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern.
Statistics
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PSSM-Id: 173626
View PSSM: cd05034
Aligned: 20 rows
Threshold Bit Score: 490.68
Threshold Setting Gi: 18250298
Created: 17-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    # ###   #           # #                                           #
1Y57_A      179 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSe-ePIYIVT 257
1QPJ_A        8 WEVPRETLKLVERLGAGQFGEVWMGYYNgHTKVAVKSLKQGSmsPDAFLAEANLMKQLQHQRLVRLYAVVTq-ePIYIIT 86
3A4O_X        8 WEIPRESIKLVKRLGAGQFGEVWMGYYNnSTKVAVKTLKPGTmsVQAFLEEANLMKTLQHDKLVRLYAVVTreePIYIIT 87
2SRC_A      179 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSe-ePIYIVT 257
gi 125717   233 WEIPRESLRLNRKLGAGQFGEVWAGVWNnTTQVAVKTLKPGTmsPASFLDEAGVMKKLRHKHLVQLYAICSdrePIYIVT 312
gi 17978636 239 WEIPRESLRMTRRLGHGQFGEVWQGVWNgNTPVAVKTLKEGTmsPAAFLAEANVMKKVRHERLVQLYAVCSdrePIYIVT 318
gi 37776869 339 WEIPKSSIILKEKIGQGQFGEVFKAVWNkTTIVAVKTLKPSScdAADFLREAQTMKRLHHPNLIQLYAVCTqtePFYIVT 418
gi 41352677 295 WEIPRRSIKLERKLGNGQFGEVWEGTWNgTVRVAVKTLKEGAmdPTAFLQEANIMKKLRHPKLVALLAVCSegePIYIVT 374
gi 4503787  227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNnTTPVAVKTLKPGSmdPNDFLREAQIMKNLRHPKLIQLYAVCTledPIYIIT 306
gi 7578848  297 WEISKSSIVLIEKLGAGQFGEVWKGTWNgTTEVAVKTLKQGTmtKEDFLKEARIMRAAQHPKLVRLYAVCTe-dPIYIVT 375
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ###   #                                        #   ## #          #              
1Y57_A      258 EYMsKGSLLDFLKgetgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEd---NE 334
1QPJ_A       87 EYMeNGSLVDFLKtpsgikLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEd---NE 163
3A4O_X       88 EYMaKGSLLDFLKsdeggkVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEd---NE 164
2SRC_A      258 EYMsKGSLLDFLKgetgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEd---NE 334
gi 125717   313 EYMsGGSLLDYLSkgegvnLQLPTLIDMAAQVASGMAFLEAQGYIHRDLAARNILVGENYICKVADFGLARLIEd---DE 389
gi 17978636 319 ELMsNGSLLDYLKdgtgkdTKLTTHVDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEe---DE 395
gi 37776869 419 EYMsKGSLLNYLQspegnaLNMQCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHAVKIADFGLARMIHn---RE 495
gi 41352677 375 ELMtNGCLLDYLHegegkqLREPELIDITAQVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRIIE----DE 450
gi 4503787  307 ELMrHGSLQEYLQndtgskIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKvdneDI 386
gi 7578848  376 ELMcNGSLLQYLRdgpgknLLINQLVDMMAQIANGMAYLEKEHYIHRDLAARNILVGENNCVKVADFGLARMVE----DH 451
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #####        #                                 #                        
1Y57_A      335 YTARq---GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPEcPESLH 411
1QPJ_A      164 XTARe---GAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHgRIPYPGMTNPEVIQNLERGYRMVRPDNcPEELY 240
3A4O_X      165 YTARe---GAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYgKIPYPGRTNADVMTALSQGYRMPRVENcPDELY 241
2SRC_A      335 YTARq---GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPEcPESLH 411
gi 125717   390 YTAHe---GAKFPIKWTAPEAALYNRFTIKSDVWSFGILMAEIVTKgRIPYPGMTNAQTIAEVEKGYRMPIMPGcPEPLY 466
gi 17978636 396 YMARv---GAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFgRIPYPGMTNREVLDQVDLGYRMPKMHHcPDSLY 472
gi 37776869 496 YVAHa---GARFPIKWTSPEAANYSRFTIKSDVWSFGILLTEIVTYgRSPYPGMHNAEVLRQVDAGYRMSKPPGcPPELY 572
gi 41352677 451 YIAKe---GAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKgRVPYPGMVNREVLDQVSRGYRMPKPPEcPDQLY 527
gi 4503787  387 YESRh---EIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYgKMPYSGMTGAQVIQMLAQNYRLPQPSNcPQQFY 463
gi 7578848  452 YCTYmaqkSTKFPIKWTAPEAALMGRFTIKSDVWSFGIVIYELITLgQVPYPSMNNTETLHQVSTGYRMPRPVNcPQPIY 531
                       250       260
                ....*....|....*....|....*..
Feature 1                                  
1Y57_A      412 DLMCQCWRKePEERPTFEYLQAFLEDY 438
1QPJ_A      241 QLMRLCWKErPEDRPTFDYLRSVLEDF 267
3A4O_X      242 DIMKMCWKEkAEERPTFDYLQSVLDDF 268
2SRC_A      412 DLMCQCWRKePEERPTFEYLQAFLEDY 438
gi 125717   467 NIMLQTWNKdPENRPTFDYLQGVLEDY 493
gi 17978636 473 EIMLKCWHKdPQQRPTFEFLHFCLDDY 499
gi 37776869 573 DLMLECWAAdENKRPSFATIHFRLEQF 599
gi 41352677 528 DITKQCWDAvPEKRPTFEFLHSFLDDF 554
gi 4503787  464 NIMLECWNAePKERPTFETLRWKLEDY 490
gi 7578848  532 DMLLRIWDScPEKRPTFSSLFEFFEDY 558

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