1Y57,2DQ7,1QCF,2HK5,1QPJ,3A4O,2SRC


Conserved Protein Domain Family
PTKc_Src_like

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cd05034: PTKc_Src_like (this model, PSSM-Id:173626 is obsolete and has been replaced by 270630)
Click on image for an interactive view with Cn3D
Catalytic domain of Src kinase-like Protein Tyrosine Kinases
Protein Tyrosine Kinase (PTK) family; Src kinase subfamily; catalytic (c) domain. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) proteins are cytoplasmic (or non-receptor) tyr kinases which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern.
Statistics
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PSSM-Id: 173626
View PSSM: cd05034
Aligned: 20 rows
Threshold Bit Score: 490.68
Threshold Setting Gi: 18250298
Created: 17-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ###   #           # #                                           #
1Y57_A    179 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSe-ePIYIVT 257 human
1QPJ_A      8 WEVPRETLKLVERLGAGQFGEVWMGYYNgHTKVAVKSLKQGSmsPDAFLAEANLMKQLQHQRLVRLYAVVTq-ePIYIIT 86  human
3A4O_X      8 WEIPRESIKLVKRLGAGQFGEVWMGYYNnSTKVAVKTLKPGTmsVQAFLEEANLMKTLQHDKLVRLYAVVTreePIYIIT 87  human
2SRC_A    179 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSe-ePIYIVT 257 human
P17713    233 WEIPRESLRLNRKLGAGQFGEVWAGVWNnTTQVAVKTLKPGTmsPASFLDEAGVMKKLRHKHLVQLYAICSdrePIYIVT 312 Hydra vulgaris
AAL50111  239 WEIPRESLRMTRRLGHGQFGEVWQGVWNgNTPVAVKTLKEGTmsPAAFLAEANVMKKVRHERLVQLYAVCSdrePIYIVT 318 purple urchin
CAE51198  339 WEIPKSSIILKEKIGQGQFGEVFKAVWNkTTIVAVKTLKPSScdAADFLREAQTMKRLHHPNLIQLYAVCTqtePFYIVT 418 Schistosoma mansoni
AAS01047  295 WEIPRRSIKLERKLGNGQFGEVWEGTWNgTVRVAVKTLKEGAmdPTAFLQEANIMKKLRHPKLVALLAVCSegePIYIVT 374 Patiria miniata
NP_002022 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNnTTPVAVKTLKPGSmdPNDFLREAQIMKNLRHPKLIQLYAVCTledPIYIIT 306 human
AAF64151  297 WEISKSSIVLIEKLGAGQFGEVWKGTWNgTTEVAVKTLKQGTmtKEDFLKEARIMRAAQHPKLVRLYAVCTe-dPIYIVT 375 Schistosoma mansoni
Feature 1     ###   #                                        #   ## #          #              
1Y57_A    258 EYMsKGSLLDFLKgetgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEd---NE 334 human
1QPJ_A     87 EYMeNGSLVDFLKtpsgikLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEd---NE 163 human
3A4O_X     88 EYMaKGSLLDFLKsdeggkVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEd---NE 164 human
2SRC_A    258 EYMsKGSLLDFLKgetgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEd---NE 334 human
P17713    313 EYMsGGSLLDYLSkgegvnLQLPTLIDMAAQVASGMAFLEAQGYIHRDLAARNILVGENYICKVADFGLARLIEd---DE 389 Hydra vulgaris
AAL50111  319 ELMsNGSLLDYLKdgtgkdTKLTTHVDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEe---DE 395 purple urchin
CAE51198  419 EYMsKGSLLNYLQspegnaLNMQCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHAVKIADFGLARMIHn---RE 495 Schistosoma mansoni
AAS01047  375 ELMtNGCLLDYLHegegkqLREPELIDITAQVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRIIE----DE 450 Patiria miniata
NP_002022 307 ELMrHGSLQEYLQndtgskIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKvdneDI 386 human
AAF64151  376 ELMcNGSLLQYLRdgpgknLLINQLVDMMAQIANGMAYLEKEHYIHRDLAARNILVGENNCVKVADFGLARMVE----DH 451 Schistosoma mansoni
Feature 1             #####        #                                 #                        
1Y57_A    335 YTARq---GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPEcPESLH 411 human
1QPJ_A    164 XTARe---GAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHgRIPYPGMTNPEVIQNLERGYRMVRPDNcPEELY 240 human
3A4O_X    165 YTARe---GAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYgKIPYPGRTNADVMTALSQGYRMPRVENcPDELY 241 human
2SRC_A    335 YTARq---GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPEcPESLH 411 human
P17713    390 YTAHe---GAKFPIKWTAPEAALYNRFTIKSDVWSFGILMAEIVTKgRIPYPGMTNAQTIAEVEKGYRMPIMPGcPEPLY 466 Hydra vulgaris
AAL50111  396 YMARv---GAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFgRIPYPGMTNREVLDQVDLGYRMPKMHHcPDSLY 472 purple urchin
CAE51198  496 YVAHa---GARFPIKWTSPEAANYSRFTIKSDVWSFGILLTEIVTYgRSPYPGMHNAEVLRQVDAGYRMSKPPGcPPELY 572 Schistosoma mansoni
AAS01047  451 YIAKe---GAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKgRVPYPGMVNREVLDQVSRGYRMPKPPEcPDQLY 527 Patiria miniata
NP_002022 387 YESRh---EIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYgKMPYSGMTGAQVIQMLAQNYRLPQPSNcPQQFY 463 human
AAF64151  452 YCTYmaqkSTKFPIKWTAPEAALMGRFTIKSDVWSFGIVIYELITLgQVPYPSMNNTETLHQVSTGYRMPRPVNcPQPIY 531 Schistosoma mansoni
Feature 1                                
1Y57_A    412 DLMCQCWRKePEERPTFEYLQAFLEDY 438 human
1QPJ_A    241 QLMRLCWKErPEDRPTFDYLRSVLEDF 267 human
3A4O_X    242 DIMKMCWKEkAEERPTFDYLQSVLDDF 268 human
2SRC_A    412 DLMCQCWRKePEERPTFEYLQAFLEDY 438 human
P17713    467 NIMLQTWNKdPENRPTFDYLQGVLEDY 493 Hydra vulgaris
AAL50111  473 EIMLKCWHKdPQQRPTFEFLHFCLDDY 499 purple urchin
CAE51198  573 DLMLECWAAdENKRPSFATIHFRLEQF 599 Schistosoma mansoni
AAS01047  528 DITKQCWDAvPEKRPTFEFLHSFLDDF 554 Patiria miniata
NP_002022 464 NIMLECWNAePKERPTFETLRWKLEDY 490 human
AAF64151  532 DMLLRIWDScPEKRPTFSSLFEFFEDY 558 Schistosoma mansoni

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