1VLG,3E6R,1KRQ,2JD6,1EUM,1Z4A


Conserved Protein Domain Family
Nonheme_Ferritin

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cd01055: Nonheme_Ferritin 
Click on image for an interactive view with Cn3D
nonheme-containing ferritins
Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.
Statistics
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PSSM-Id: 153113
View PSSM: cd01055
Aligned: 144 rows
Threshold Bit Score: 121.055
Threshold Setting Gi: 26553747
Created: 24-Sep-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ferroxidase
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ferroxidase diiron center [ion binding site]
Evidence:
  • Comment:Iron(II) oxidation by molecular oxygen to iron(III).
  • Structure:1VLG_A; Thermatoga maritima ferritin binds iron.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                ##  #                            
1VLG_A        17 SEKVRKALNDQLNREIYSSYLYLSMATYFDAe-GFKGFAHWMKKQAQEELTHAMKFYEYIYERGGRVELEAIEKPps--- 92
gi 33634684    1 MNDLTKAINLHLACEFQASHTYLAMSIWLREk-DLAGFSSYMQIKSQEERGHADRLIAYLVDCDEQVELPAVEAPqr--- 76
gi 113953047  19 NPDLLSAIQQHISIERYASVTYLAMSIWCAEr-ELAGFYQFFDGEAKDEQSHAVHFTQYLIARSQSNDLQTLDAPrq--- 94
gi 113954205  28 TQEMVEQLQAHLNLERQSSAAYFAAAIWFAEr-ELTGFAEYLRNEGKQEQEHAAKFADYLISRGQTVELDTIEAPrq--- 103
gi 116074582   2 SQELVGAIQQHINLELEASMTYLSMSIWCAEr-ELAGFYKFFSAESAEERGHAIQFADYLVARAQRNDLQPLQAPcq--- 77
gi 87302532   28 EAELHQGLCNHLQMELMASYTYFSLAVWFTQr-ELNGFAAFARAESDGERAHAGLFVDYLVARSQPVELSALSQPrq--- 103
gi 16760880    3 AVGMVQKLNTPMNLEFYASNLYLHLSEWCSEh-SLTGTATFLRTQAQGNVTQMMRMFNFMKNAGATPIVKAIDVPge--- 78
gi 26553747    9 DERIMDLVSKHYNVELCAANLYFHLATVSKAlgYDNVAAFFVKMGSDKQSAHMSRLVKYMMKVDSILKINQISVPel--v 86
gi 110004363   3 TKDIEKDLQHYIDEHIKMQFFCYNLSSAADKl-GFPGFSHYFQVQAQDEVLHQRRIMNFVLDRDGHYQIKNIAEEyk--- 78
gi 156933508   3 PLGVVQKLNAQMNQEFYASNLCLYYSDWCAQq-SLNGSATVLRQQAQHNVTQMMRLFDYLKQTGANPVVGALKSVkpdcs 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #                               #  ##                            
1VLG_A        93 nWNGIKDAFEAALKHEEFVTQSIYNILELASeekDHATVSFLKWFVDEQVEEEDQVREILDLLEKANGqmsVIFQLDRYL 172
gi 33634684   77 nWGSTQDLFDQVYELEKDVTASINRIYSIAEqagERSATAMLDWFIAEQLQEEAEARFVRKRLRLAGDntaALLLLDQQF 156
gi 113953047  95 nWDSLASLMATAFQMEADTTSSIQSVYALAErnsDTRTTVFLDPLIEAQIQSEDQFAYLLGRVKFANGdptALLVIDNEL 174
gi 113954205 104 tWPDPEEVIANVFRMEADVTTSVLLLYSIAErasDQRTTVFLDPVVDDQRISEHEAAYLLGRVKYANNeraAMMIIDAEL 183
gi 116074582  78 nWSKLEDVVFSSFRMEADTTSSIQHLYSIAErenDVRTTVFLDPLLEQQIGSEDQYAYLHGRIKFADNdstALLVIDGEV 157
gi 87302532  104 tWTNVEDVLVSVFEMEAEVTTSLQQLYSLAErcgDYRSSIFLDPLIKSQVDAESEVAHLLAQVRHCGTdfgALLILDQSL 183
gi 16760880   79 eLCSLEELFQKTLEDYQQRASTLSRLADEAKalnDASTLDFLHTLEKEQQQDGVLLQTILEEVRSAKRa--GLCLAQTDQ 156
gi 26553747   87 sFETIQEVLDAALKMESKVRESVKNVTEISLlakDFETFERMQWFVKDSIEDLEEISDVWTYVHSPNV---NLINIENIV 163
gi 110004363  79 dIKNIIELMETYQTKRAYFAELTNKLAQHANtvgDLVTYKFYDWFIIDFYEELAEVKDIIEWIKMSNN---NYYEIDRKM 155
gi 156933508  82 sLEAIFHQMQDELGGRHAALARLMSEAQAAR---DDAMLAMLGEFEQELRQDEALLATILNELTQARQaglCAEEADQRL 158

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