Conserved Protein Domain Family
CLECT_1

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cd03602: CLECT_1 
C-type lectin (CTL)/C-type lectin-like (CTLD) domain subgroup 1; a subgroup of protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins
CLECT_1: C-type lectin (CTL)/C-type lectin-like (CTLD) domain subgroup 1; a subgroup of protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers from which ligand-binding sites project in different orientations. In some CTLDs a loop extends to the adjoining domain to form a loop-swapped dimer.
Statistics
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PSSM-Id: 153072
View PSSM: cd03602
Aligned: 19 rows
Threshold Bit Score: 118.63
Threshold Setting Gi: 47213476
Created: 24-Mar-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
ligand binding
Feature 1:ligand binding surface [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 55963419   23 RRYLFINEKKNWTEAQRYCRENYTDLATVDNm-------NDMNQLKncvnn--ggnqNIWIGLhkts--vynWHWSSGdp 91
gi 33284862   21 RTHFFVTEQMTWKDAQTYCRKHHSDLSTVTK--------EEAQLLSsntd---atysFSWIGLyedpdradeWIWSGGqm 89
gi 47213476  139 RRFYLEERSMNWSDAQAFCRRRYADLAWVRNk-------QENQALRdvs-----rngTAWIGLsk-----qsWRWSDRsq 201
gi 47213476   20 NPYYFSNVSSTWLQAQQYCRKRLGDLATVNDl-------EDLEQLAalve---vsnrVMFLGLrrq----waWSVSDGdd 85
gi 68359004  228 SEFILINEVKSWTEAQAFCKEFHVDLPTVQMd-------KDRLEIQkassa--vngvKAWVGLygg---iceWRWSYDne 295
gi 68362756  150 KPYVLIDLLYTWREAQRYCRRYYTDLVSVRNr-------KEIEQIKklip----lppYAYIGLfr-----dtFLWSSNst 213
gi 68362756 1152 QEYIFIPKLMVWNQAQNYCRANHLDLATVQTd-------EDWATLQetafe-vgyygLAWIGLydd---vlyWLWTHNne 1220
gi 68399977  343 AEYVLVDTYKSWTEAADYCGQKYIDLASAQTagdwsrftELSAAYSq---------pEAWVGLydd---vdsWRWSYQee 410
gi 68400284  278 RGLVFVNESMNWREAQSYCRQKHIDLVSVRNq-------IESQQLEkfikdrnssgsAVWIGLfr-----dtWQWSDQsn 345
gi 68433115  411 RQFYILKQRVNVSAAQSLCRVNYTDLVTVCDq-------QDNIKLLqllrn--ssspAGWIGAsrg---nysLKWSNGdd 478
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                            #   # #      # ####  ###      
gi 55963419   92 ---aLFLNWtsgq---pagsDDCAYIIn----gQWCVWKCnVFLPFICYD 131
gi 33284862   90 ---eEVDNWdtdqp--ddntQHCVSLNqs--tsKLHDTLCsDMLSFYCMD 132
gi 47213476  202 ---aTFLPWktpa----ppqGDCGALDvrgetpAITQANCaGNASFLCSR 244
gi 47213476   86 yregEPAYWnwagd-depsgEACGTIGls---gKWFSSSCsSPMPFFCYN 131
gi 68359004  296 --dlQFSVWaptedpssttqSACAVIGnt---gFWYAKDCtQTKPFFCYN 340
gi 68362756  214 ---sSLRNWdlfq---pdiiGDCVAMLdd---kYWMTELCsKAKPFYCYH 254
gi 68362756 1221 --svVFTAWftfypdtytkhLDCGTQYfd---gRWYNFHCsELRYFVCMD 1265
gi 68399977  411 --alTFTAWesnqpnnyganEDCVMMRpn---gYWRDKKCnLICPFVKDD 455
gi 68400284  346 ---sSFRYWktkqp-ydqigEECAVIEkyt-qvQWADYTCeHQFPFVCHE 390
gi 68433115  479 --vsYSRYSlny-----snqSRCAAMTvn---gDWESILCtETKHFMCYK 518

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