1HTN


Conserved Protein Domain Family
CLECT_tetranectin_like

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cd03596: CLECT_tetranectin_like 
Click on image for an interactive view with Cn3D
C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)
CLECT_tetranectin_like: C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. TN binds to plasminogen and stimulates activation of plasminogen, playing a key role in the regulation of proteolytic processes. The TN CTLD binds two calcium ions. Its calcium free form binds to various kringle-like protein ligands. Two residues involved in the coordination of calcium are critical for the binding of TN to the fourth kringle (K4) domain of plasminogen (Plg K4). TN binds the kringle 1-4 form of angiostatin (AST K1-4). AST K1-4 is a fragment of Plg, commonly found in cancer tissues. TN inhibits the binding of Plg and AST K1-4 to the extracellular matrix (EMC) of endothelial cells and counteracts the antiproliferative effects of AST K1-4 on these cells. TN also binds the tenth kringle domain of apolipoprotein (a). In addition, TN binds fibrin and complex polysaccharides in a Ca2+ dependent manner. The binding site for complex sulfated polysaccharides is N-terminal to the CTLD. TN is homotrimeric; N-terminal to the CTLD is an alpha helical domain responsible for trimerization of monomeric units. TN may modulate angiogenesis through interactions with angiostatin and coagulation through interaction with fibrin. TN may play a role in myogenesis and in bone development. Mice having a deletion in the TN gene exhibit a kyphotic spine abnormality. TN is a useful prognostic marker of certain cancer types. CLECSF1 is expressed in cartilage tissue, which is primarily intracellular matrix (ECM), and is a candidate for organizing ECM. SCGF is strongly expressed in bone marrow and is a cytokine for primitive hematopoietic progenitor cells.
Statistics
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PSSM-Id: 153066
View PSSM: cd03596
Aligned: 11 rows
Threshold Bit Score: 207.241
Threshold Setting Gi: 34223087
Created: 21-Mar-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding surface [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1HTN         51 CLKGTKVHMKCFLAFTQTKTFHEASEDCISRGGTLSTPQTGSENDALYEYLrqsv-gneaEIWLGLNDMAAEGTWVDMTG 129
gi 45382787  70 CLKGTKIHLKCFLAFSESKTYHEASEHCISQGGTLGTPQGGEENDALYDYMrksi-gneaEIWLGLNDMVAEGKWVDMTG 148
gi 47208253  69 CLKGMKIHRKCYLVDPVRKSYHAASEDCSNLGGVLGTPTSSNENDQLRDYLrqsv-npgeQVWLGVSDMVKEGAWVDITS 147
gi 20137707  68 CLRGTKVHKKCYLASEGLKHFHEANEDCISKGGILVIPRNSDEINALQDYGkrsl-pgvnDFWLGINDMVTEGKFVDVNG 146
gi 50793953  67 CLRGTKAHKKCYLISEGTKHFHEANEDCIAKGGTLAIPRNSDEMNTLRDYGknsv-pggsEFWLGVNDMVNEGKFVDVNG 145
gi 51593195  66 CLRGTKIHKKCYLSFEETKHFHEANEDCIAKGGTLAIPRDSEENNALRDYGkksl-hgsgEFWLGINDMVNEGKFVDVNG 144
gi 68438079  36 CLRGIKAHRKCYLVSDQAKHYHEANEDCISQGGTLAIPRDVNENEELRDYAkrss-paarDFWIGITDIVREGQYVDVNS 114
gi 56971206  67 CLKGMKIYNKCFLAFNELKTYHQASDVCFAQGGTLSTPETGDENDSLYDYVrksi-gssaEIWIGINDMATEGTWLDLTG 145
gi 68429809  52 CLKGFKIPGKCFLVDTVKKDFHSANDDCIAKGGILSTPMSGHENDQLQEYVqqtv-gpetHIWLGVNDMIKEGEWIDLTG 130
gi 47222448  85 CQKGRRIGYKCYLVYNSYEDYAGASRKCLERGGRMAMPRDRKEQEALADYVkaffhpgnwPVWLGINDLQSEGTYLYDDG 164
gi 34223087 177 CLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLraalapynwPVWLGVHDRRAEGLYLFENG 256
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                            #   # #     # ####  ###      
1HTN        130 ARIAYKNWete----------------itaQPDGGKtENCAVLSgaanGKWFDKRCRDQLPYICQF 179
gi 45382787 149 SPIRYKNWete----------------ittQPDGGKlENCAALSgvavGKWFDKRCKEQLPYVCQF 198
gi 47208253 148 TNITYKNWdts-----------------ngQPDGGRsQNCAVLSgasnGKWLDENCKEEKASVCQF 196
gi 20137707 147 IAISFLNWdr-------------------aQPNGGKrENCVLFSqsaqGKWSDEACRSSKRYICEF 193
gi 50793953 146 MALQYFNWdr-------------------aQPNGGKrENCVFFSt--qGKWVDEICRTAKRYICEF 190
gi 51593195 145 VAITYFNWe--------------------rIPKGGKrKNCALLNqasqGKWVDEVCRSLKKYICEF 190
gi 68438079 115 LPVSFFYWdra-----------------kkEPTGGKrESCVALSlsaqGKWHDEVCRSQKKYICEY 163
gi 56971206 146 SPISFKHWete----------------ittQPDGGKqENCAALSasaiGRWFDKNCKTELPFVCQF 195
gi 68429809 131 SPIRFKNWese----------------ithQPDGGRtHNCAVLSstanGKWFDEDCRGEKASVCQF 180
gi 47222448 165 AQVSYFQWrkhf---------------lssQPDGGRrENCVAMAsd-dGDWWDHYCDRAMNYVCEF 214
gi 34223087 257 QRVSFFAWhrsprpelgaqpsasphplspdQPNGGTlENCVAQAsd-dGSWWDHDCQRRLYYVCEF 321

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