Conserved Protein Domain Family
APC_crr

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pfam05923: APC_crr 
APC cysteine-rich region
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Statistics
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PSSM-Id: 147850
View PSSM: pfam05923
Aligned: 30 rows
Threshold Bit Score: 30.0724
Threshold Setting Gi: 82178450
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam05923 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30
                  ....*....|....*....|....*....|
gi 74820257   506 QDQPKVYN-VENTPNHgTTSRSpkISRSPT 534
gi 82271974  1405 DDSSLTDS-AEGTPAY-FSTTT--SLSDET 1430
gi 81872882  1244 DAGSVRFT-VEKPDEN-FSCAS--SLSALA 1269
gi 12643510  1484 VDTLLHFA-TESTPDG-FSCSS--SLSALS 1509
gi 122098033 1212 SDEMSKYL-VEDSPCN-FSVVS--GLSNLT 1237
gi 74844798   736 EDKLNRFH-VEHTPAA-FSCAT--SLSNLS 761
gi 74834692  1065 EDDLSSFN-VEHTPAQ-FSTAT--SLSNLS 1090
gi 74820257  1038 MDQVKFFQmVEDTPNQgHSRTS--SNTSLV 1065
gi 122098033  835 DDSVKCYQ-TEDTPYV-ISNAA--SVTDLR 860
gi 122098033 1112 EETTRSYC-TEDTPAL-LSKVG--SHTNLS 1137
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