Conserved Protein Domain Family
ASF1_hist_chap

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pfam04729: ASF1_hist_chap (this model, PSSM-Id:147073 is obsolete and has been replaced by 309739)
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ASF1 like histone chaperone
This family includes the yeast and human ASF1 protein. These proteins have histone chaperone activity. ASF1 participates in both the replication-dependent and replication-independent pathways. The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers.
Statistics
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PSSM-Id: 147073
View PSSM: pfam04729
Aligned: 25 rows
Threshold Bit Score: 167.791
Threshold Setting Gi: 146082359
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2Z3F_G         1 MS---IVNILSVNVL-NNPAKFSDPYKFEITFECLEPLKSDLEWKLTYVGS----------------------------- 47
gi 122052169   1 MS---LINVTNIKIG-NNVCSIKLPLIFQIEFECLEDLKHDVEWKVIYITSdgsgyvnstsnsegntdnsvdnmmeqeke 76
gi 74776904   10 MS---LVNVTSVKVF-KNPTEITDPFEFEISFECLQNLEEDLEWKIVYISC----------------------------- 56
gi 121959603   1 MS---VVNVTNIRLG-NNPSPISSPFVFEICFEALTPLKEDIEWRVVYVGS----------------------------- 47
gi 124448369   1 MS---LVNITNIVID-DKPQPFQSPIIIDIYFDVLVDIEDEIEWMLLFIGS----------------------------- 47
gi 124447094   1 MA---LVEVTNIIFE-NELALFQTPISLQITFEVLNSLPDEIEWNLIYIGS----------------------------- 47
gi 124450092   1 MA---LINITNIVFD-QDTALFNSPIQMQITFDVMRQLDEEIEWKLIYIGS----------------------------- 47
gi 122049496   1 MSiqpIVQLLEIELIgDNPSSYTQPMHWRMRLEALEALDDTISIAFVWVGS----------------------------- 51
gi 156089725   1 MS---LVNVTNITVG-NNVCPVTAPLVFQIEFECLEDLKHDVEWKIIYVTSdghgyld------------------sqes 58
gi 156103281   1 MS---EVNVTKVIVN-NPICDILDPFVFTIEFEALNKLEADLEWKIFYISA----------------------------- 47
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2Z3F_G        48 --ATSQSY-----------------------------------------------DQILDTLLVGPIPIGINKFVFEADP 78
gi 122052169  77 ylVSNNKG-----------------------------------------------EIILDAVCLGPLYKGILEFEFRVNP 109
gi 74776904   57 --AESKDM-----------------------------------------------DQELDCIALGPITRGALKFIFKAPS 87
gi 121959603  48 --AECEKKarkkeklaalsssglpshqsladgervegdmdveedenakkkeegggDYLLDSVMLGPIERGVLAFEFAVNA 125
gi 124448369  48 --PKDESH-----------------------------------------------DQILDQFSMGPLQGGAKHFTLECNP 78
gi 124447094  48 --PLSDKY-----------------------------------------------DQVLDNFSMGPLQKGLMQFTITSQP 78
gi 124450092  48 --PNSDKY-----------------------------------------------DQVLEQFSMPPLQQGTMQFTLMSSG 78
gi 122049496  52 --AASPNH-----------------------------------------------DQVLDSFDVGPLAQGVTEFTMECDP 82
gi 156089725  59 ndTQNSEG-----------------------------------------------EIVLDAVCLGPIYKGILEFEFRVAP 91
gi 156103281  48 --VNNDGEgn--------------------------------------------qDIELDNIFLGPIERGVMMFDYAVNP 81
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2Z3F_G        79 PNIDLLPqLSDVLGVTVILLSCAYEDNEFVRVGYYVNNEMEGLNLQEMDDAeikkvKVDISKVWRSILaEKPRVTRFNIQ 158
gi 122052169 110 PNFSRLR-PESVLGMQAILISGNYCDQEFIRIGYYTNNVYDEESLVENPPD-----LPILDKIVRCII-DQPRVTRFPIK 182
gi 74776904   88 PDFTKIP-PEDIHGMAVVLILGSYRNEEFIRIGYYVHNVYTDPLLEDNPPD-----IPILDKLQRIILsESPRLTRFNIG 161
gi 121959603 126 PDYTKMD-PSSVVGMQAVLVCALYKQQEFMRIGYYLNNAYSDTVLRENPPD-----VPIYDKLVRCIV-DEPRVTRFPIV 198
gi 124448369  79 PDWQKIP-QNELLGITAFILTCSYREKEFFRAGYYVYTTYTSQENIENDPP-----EIIIEDISRQIFnNKPRITRFEID 152
gi 124447094  79 PNYQLIPsKEDLFSVSALILTAKYRQKEFFRVGYYVYNNYTEAELIENEPQ-----VVLIDRVYRQILgSNPRITKFPID 153
gi 124450092  79 PNFELIPsKDDLFGASAIILSVKYRKQEFFRVGYYVYNTYLEPELIENDPP-----QVLIDRVYRQINtSAPRVTRINID 153
gi 122049496  83 PQVELVP-TQEVLGVTILVISFQYREQEFLRVGYYTQVAYFDGRMNNCPPP-----VPQVELMGRFIAmPRPTVTVTPIA 156
gi 156089725  92 PDFNKLD-PNGILGMQAVLVTASYCDQEFIRIGYYTNNCYDDPELRECPPD-----TPIIEKMVRCII-DQPRVTRFPIK 164
gi 156103281  82 PDYKNMD-VDSVLGLQAILISANYKEKEFIRIAYYMNSFYKDTELREKPPA-----VPQYDKICRHIFvENPRIVKFCIT 155

                 ..
2Z3F_G       159 WD 160
gi 122052169 183 WD 184
gi 74776904  162 WD 163
gi 121959603 199 WD 200
gi 124448369 153 WK 154
gi 124447094 154 WE 155
gi 124450092 154 WE 155
gi 122049496 157 WN 158
gi 156089725 165 WD 166
gi 156103281 156 WD 157
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