Conserved Protein Domain Family
KilA-N

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pfam04383: KilA-N (this model, PSSM-Id:146823 is obsolete and has been replaced by 309501)
KilA-N domain
The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.
Statistics
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PSSM-Id: 146823
View PSSM: pfam04383
Aligned: 143 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 17-Nov-2009
Updated: 5-Jan-2010
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75549715   19 IYYGKLKVIVMK-DCGYFNATKICSHf----nKEFHNWQRFESSKCLTDVINKII---------------------R--- 69
gi 123202842  23 IQYNKQLRLIRSvKDDMYQMQSILTAcfapdtKLPKDWFRNQSTIELLNEAENST---------------------T--- 78
gi 123422794  23 IQFNKQLRLIRSvKDDMYQVQSILTAcfapdtKKPQDWFRNQSTIELLNEAENSTtdflvvakth--enreeqrvsK--- 97
gi 123316559  23 VQFNKQLRLIRSvKDDMYQMQSILTAcfapdtKHTDDWFKNQSTQELLSEAQRDI---------------------Lfse 81
gi 123349267  23 VQFNKQLRLIRSvKDDMYQMQSILTAcfapdtKKPQDWFRNQSTQELLNEAQRDI---------------------L--- 78
gi 123291919  20 GTYNGIEVL-RRdKDGYINATKMAREag--klNHLNRFLNSAKMQEILEFWLKEY---------------------G--- 72
gi 123470538   8 alislcieVLRRdKDGYINATKMAREag--klNHLNRFLNSAKMQEILEFWMNEYgraksgstskqafceeytnrkN--- 82
gi 123976963  23 IQFNKQLRLIRSvKDDMYQMKSILTAcfapdtKKPQDWFRNQSTIELLNEAENST---------------------Trnp 81
gi 123346680  23 VQFNKQLRLIRSvKDDMYQMQSILTAcfapdtKKPQDWFRNQSTQELLSEAQRDI---------------------L--- 78
gi 123382171  23 VQFNKQLRLIRSvKDDMYQMQSILTAcfapdtKKPQDWFELNSTHELLSEFEHEE------------------------- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75549715   70 ---------------------------P------------------------------NK-------------------- 72
gi 123202842  79 ---------------------------DflvvaktrvgekpqspklyenseeqrvgekPQ-------------------- 111
gi 123422794  98 ---------------------------K------------------------------PQ-------------------- 100
gi 123316559  82 nseeqrarlpsgspkthenseeqrarlP------------------------------SG-------------------- 111
gi 123349267  79 ---------------------------F------------------------------SEnreeqrvggkpqspk----- 96
gi 123291919  73 ---------------------------R------------------------------AK-------------------- 75
gi 123470538  83 ---------------------------F------------------------------DG-------------------- 85
gi 123976963  82 vvaktrvgekpqspklyenseeqrlreK------------------------------PQ-------------------- 111
gi 123346680  79 ---------------------------F------------------------------SEnseeqrvskkpqspklyenr 101
gi 123382171     --------------------------------------------------------------------------------
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75549715   73 ----------------------------CLIni-----pSEYGRDNCTSGTYVHPLLFPHVLSWLSFRYAIQISKIINNM 119
gi 123202842 112 ----------------------------SPKly-----eNREKLPNGLRGYYVHRLLVNAVAMWASPRYAWYIYRLLDEI 158
gi 123422794 101 ----------------------------SPKly-----eNRQNLPNGLRGWYVHRLLVNSVAMWASPRYAWYIFMMLDEI 147
gi 123316559 112 ----------------------------SPKly-----eNRKNLPNGLRGWYVHRLLVNAVAMWASPRYAWNVYKLLDEI 158
gi 123349267  97 -------------lyenseeqrvrkkpqSPKly-----eNREKLPNGLRGYYVHRLLVNAVAMWASPRYACYIFMMLDEI 158
gi 123291919  76 ----------------------------SGStskqafyeLTKGVMNEFKGIYIHADLVHFVAEWCSVKYAFYVKDIMDSI 127
gi 123470538  86 ----------------------------CFLykv---haGIPDEIKQVRGTYVDPRLVNYIAMWASPKYCIAVGKILDSI 134
gi 123976963 112 ----------------------------SPKly-----eNREKLPNGLRGYYVHRLLVNNVAQWASARYSWYVCKLLDEI 158
gi 123346680 102 eeqrvskkpqspklyenseeqrvskkpqSPKly-----eNREKLPNGLRGYYVHRLLVNAVAMWASPRYAWYIYRLLDEI 176
gi 123382171  78 ----------------------------LKKmy-----qDRQNLPSHLKGIYVHKFLVSSIAMWASPRYAIYILMLLDEL 124

                 ...
gi 75549715  120 HSR 122
gi 123202842 159 HRQ 161
gi 123422794 148 HRQ 150
gi 123316559 159 HRQ 161
gi 123349267 159 HRQ 161
gi 123291919 128 DKK 130
gi 123470538 135 DKK 137
gi 123976963 159 HRQ 161
gi 123346680 177 HRQ 179
gi 123382171 125 CTK 127
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