Conserved Protein Domain Family
Creatininase

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pfam02633: Creatininase (this model, PSSM-Id:145669 is obsolete and has been replaced by 335018)
Creatinine amidohydrolase
Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyses the hydrolysis of creatinine to creatine.
Statistics
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PSSM-Id: 145669
View PSSM: pfam02633
Aligned: 164 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 17-Nov-2009
Updated: 5-Jan-2010
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123523859   6 LLECSYVDA-QEW----FKETDTVMVPVGS-CEKHGAHVPLGTDSFTTISVTERAAKIA----N-----VPYTPLLPFGY 70
gi 123381567  29 WEELTASDFiKGM----GDAHNTCALPIGI-LEKHGPHMPIGTDLLNVRYAALHAAEKE----Y-----VIVFPEYYFGQ 94
gi 81481957    3 LINYTSDDF-QKH----LQKSDTVIVPIGS-VEAHGHHLPLGTDIFSPRLFCQMIEEKI----Gd---yVWIAPEIPYGQ 69
gi 74509002    2 LVELNL----DAGniisEDVHRIGILAVGShLENHGPALPIDTDAKIASYVALEAALRT----Gar-flGVLYAASEFPY 72
gi 145591227   3 WAELTWPDF-ERV----DK--KVAVLPVGV-IEAHGPHLPLGTDALMALYVAEKAAEEA----G-----VLLLPPIWYGS 65
gi 159040706   3 WWELTWPDF-EKV----DK--TIAILPTGI-VEAHGPHLPLGTDALMATYIAEEAARRTn---------ALLLPTVWYG- 64
gi 149174717  12 LSEINYAYV-KE------NPYQVAVLPMGA-TEPHNLHLPYGTDTYEADAISSRVCEAA----HqrgakVVMLPPIPYGT 79
gi 260063609   6 LAETNWKAL-KE------TRFDLAILPWGA-TEAHNYHLPYGTDNYEADALAAAAAAHAweagGr----VVVLPTIPFGV 73
gi 87307228    9 LSEVNYGYV-KE------NPYEVAVLPLGA-TEPHNLHLPYGTDMYEGTVIGERICAAA----HqqgakVVLLPTMPYGT 76
gi 150399755   1 --mdkmelrynsgnilnEEVHKIGIIALGSfLENHGSALPIDTDAKIASYIGLNVSILT----Gak-flGVVIPSTEYSY 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123523859  71 --SAHHMgR-VGegcGTVTLSAETFRRV-LYDIARSLI-YHGANKIVFVTHHGSNTKPIDELLRKLRYQ-TGAFVAFYKT 144
gi 123381567  95 ifEARQE----P---GTIAYSLDLQLKL-LQETVNEMA-RNGCKKIVIINGHGGNESLLPLFAQAQLATpKDFVVFVYGL 165
gi 81481957   70 --SYDLS-V-YP---GTIHVPSEVLAEY-VYAVGKSLY-ENELKKLIFLNGHGGNINALNLASEKLAQL--GMTVLTINW 138
gi 74509002   73 ----------VK---HGIHMDRDELVEReLKPVLRKARrLLNLEAAVIVNGHGGNK--LEDCMDDLEEE-LGLEIAWNNR 136
gi 145591227  66 --TYVLE-K-FP---GTISISGETLYRL-YKEVFMEVA-RNGVRYLVVVNGHGGNIDALKMAAKDV-AKsTYLNIVLVNW 135
gi 159040706  65 --NTYVL-DkFP---GTISISNEVLYML-YREIFREVV-RNGVKYLVVVNGHGGNVDALSMASKDVAKE-TNLVIILVNW 135
gi 149174717  80 --ETNQA-A-FP---LSMNVNPSTLGQM-IMDLVDSLA-NHGVNKLLILNSHGGND--FKPLLRELHGs-TSVQIFLADW 147
gi 260063609  74 --NTGQA-D-IY---LDMNLNPSTQLAI-LDDVAATLH-RHGIQKLVVFNSHGGNN--FKALLRELGLRyPDLFVCMTNW 142
gi 87307228   77 --ETNMN-Q-FP---LAMNVNPSTLFLL-VTDLVKSLV-ESGIRKVVLLNSHGGNE--FKPLLRELYGK-TEAQLFLCNW 144
gi 150399755  74 ----------VK---HGIHNSPNEVVEY-IKIMIEHSK-KIGINKFLIINCHGGNT-LIKDLISELNDKkTSVIL----- 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123523859 145 PTERECEVvkgiLEGPPEETPGWHAGEMETAQMMAYDERLVDMSRavndrahapawmgpnfskkDGTVTV--------MF 216
gi 123381567 166 PRLEVP------GRPAKNDSVDMHAGSSETSHMMVTHPELLKMDKvn---------------teSGRDQD--------RL 216
gi 81481957  139 WLDFS-------KEILTITEGQGHAGEDETSAILYYDERLVQMDK---------------------ATKN--------FK 182
gi 74509002  137 ----------------IVEIEGPHAGSGELSAGLIL--GIADLRRldecip-------elypeiGMIGLK--------EA 183
gi 145591227 136 WIDLAKEA----RRKVLETPEG-HAAEDETSEVMAAYPHLV---Ke-----------------iPRDADE--------WA 182
gi 159040706 136 WIDLGREA----RRKVLETPEG-HAAEDETSEVWAAYPHLVKWIp------------------rDGSADE--------WV 184
gi 149174717 148 FRGTSADV----KAEIFEN-PDDHAGEMETSLALAYFPQLVNRDAe-----------------tGALHAD--------DG 197
gi 260063609 143 FRAMDRET--------YWEAPGDHADEAETSLMLHLRPDLVLPREs-----------------wGDGASR--------KF 189
gi 87307228  145 FRILSPED----YYEIFE-HMDDHAGEMETSLIMACQGHLVEKNAd-----------------gTLNADAgsqramqfEA 202
gi 150399755 133 -----------------ENVCFTHAAFEEIAIGYAV--GILSEDKmkthsf-------ktypeiGMIGLT--------EA 178
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 123523859 217 RG---------Se----NIFVPMEHHEYSDHATIGNPFRGTKEKGLKLFEKEAEHLAAFLE 264
gi 123381567 217 KL---------Pd----SLYTGIWWYAKFPDHFSGDPSKATRALGEFDVNTWVNSIADAFK 264
gi 81481957  183 KP---------Ly----RVYFKDRGKILYENAMSGDATLATKEKGEKIFKLLTEKIVEIIL 230
gi 74509002  184 RE---------A-----NREIDKAARICERDGVN-----PDPVLGQRILDDAVESVISDVK 225
gi 145591227 183 EA---------Ky----AVYGARVYAMMYKKAVQGYPSRASREKGEAILKAAVEELKSLLE 230
gi 159040706 185 EV---------Kf----RVYGKDAYALEYTKAVQGYPSRASVEKGKVILESAINELTQLIn 232
gi 149174717 198 ATnatrfsavnEg----WVSITRPWHLLTTNSGSGNPHQATAEKGERLMQILVDRLSQFVv 254
gi 260063609 190 RI---------EglnqdWAWAERKWSEVSADTGVGDPSAASAEKGARFFRDVSRKIGAFLl 241
gi 87307228  203 LQ---------Qg----WVSITRPWHLLTTNSGSGYPHASTAEKGEKLLEKMTERLAKFLv 250
gi 150399755 179 RL---------K-----NTDIDNEAKILEEKGAIFL----DKNYGKTLLKNLINNHVEIVK 221
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