1R4R,1R4O,1R4R,3G9P,3G6T,2C7A


Conserved Protein Domain Family
NR_DBD_GR_PR

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cd07172: NR_DBD_GR_PR 
Click on image for an interactive view with Cn3D
DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
DNA-binding domains of glucocorticoid receptor (GR) and progesterone receptor (PR) are composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinate a single zinc atom. The DBD from both receptors interact with the same hormone response element (HRE), which is an imperfect palindrome GGTACAnnnTGTTCT, upstream of target genes and modulates the rate of transcriptional initiation. GR is a transcriptional regulator that mediates the biological effects of glucocorticoids and PR regulates genes controlled by progesterone. GR is expressed in almost every cell in the body and regulates genes controlling a wide variety of processes including the development, metabolism, and immune response of the organism. PR functions in a variety of biological processes including development of the mammary gland, regulating cell cycle progression, protein processing, and metabolism. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, GR and PR have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143546
View PSSM: cd07172
Aligned: 20 rows
Threshold Bit Score: 126.869
Threshold Setting Gi: 227343768
Created: 2-Feb-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:1R4R_A; C4 type zinc finger of Rattus norvegicus Glucocorticoid Receptor, contacts determined by 4A
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the coordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1            #  #             #  #               #     #         #  #                  
1R4R_A         3 PARPCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTK 80
gi 126885    599 PSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSK 676
gi 73978292  596 PSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPVCRLQKCLLAGMKFRTRKSK 673
gi 88604786   27 PSKVCLVCADEASGCHYGVLTCGSCKVFFKRAVEGQQNYLCAGRNDCIIDKIRRKNCPACRLRKWLNAGMNLGARKSK 104
gi 13919634   64 PQKACLICSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLRKCIQAGMTLGARKLK 141
gi 88604780  233 PHKACLICRDEASGCHYGVLTCGSCKVFFKRAIEGQHNYLCAGRNDCIIDKIRRKNCPACRLRKCIQAGMMLGARKMK 310
gi 169146179 183 SQRQCVICGDEASGCHYGVLTCGSCKVFFKRAVEGHHNYLCAGRNDCIVDKIRRKNCPACRLRKCYQAGMMLGGRKMK 260
gi 19386568  319 SQKFCLICGDEASGCHYGVLTCGSCKVFYKRAVEGHQNYLCAGRNDCIVDKIRRKNCPACRLRKCYQAGMTLGGRKMK 396
gi 88604782  239 LQKLCLICGDEASGCHYGVITCGSCKVFFKRASEGHNNYLCAGRNDCIIDKMRRKNCPACRLRKCCHAGMVLGAHRSK 316
gi 45383982  417 PQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK 494

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