1HLZ,3DZU


Conserved Protein Domain Family
NR_DBD_Ppar_like

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cd07158: NR_DBD_Ppar_like 
Click on image for an interactive view with Cn3D
The DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) like nuclear receptor family
The DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) like nuclear receptor family is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. These domains interact with specific DNA sites upstream of the target gene and modulate the rate of transcriptional initiation. This family includes three known types of nuclear receptors: peroxisome proliferator-activated receptors (PPAR), REV-ERB receptors and Drosophila ecdysone-induced protein 78 (E78). Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, PPAR-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143533
View PSSM: cd07158
Aligned: 4 rows
Threshold Bit Score: 111.885
Threshold Setting Gi: 17942647
Created: 3-Feb-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:3DZU_D; Zn binding site of human Rxr Alpha Nuclear Receptor Complex DNA binding domain, contacts determined at 3.5A
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the coordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1        #  #             #  #                #     #         #  #                
1HLZ_A        10 CKVCGDVASGFHYGVLACEGCKGFFRRSIQQnIQYkRCLknenCSIVRINRNRCQQCRFKKCLSVGMSRDAVR 82
3DZU_D        53 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLkLIYdRCDl--nCRIHKKSRNKCQYCRFQKCLAVGMSHNAIR 123
gi 34223729  367 CKVCGDKASGYHYGVTSCEGCKGFFRRSIQKqIEY-RCLrdgkCLVIRLNRNRCQYCRFKKCLSAGMSRDSVR 438
gi 115728480  52 CQVCGDKASGFHYGVHSCEGCKGFFRRTVQHnLTYrPCPnggkCVIQRKNRNQCQSCRLRKCILMGMSKNAVR 124

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