Conserved Protein Domain Family
STKc_PFTAIRE2

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cd07870: STKc_PFTAIRE2 (this model, PSSM-Id:143375 is obsolete and has been replaced by 270852)
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
Serine/Threonine Kinases (STKs), PFTAIRE-2 subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PFTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known.
Statistics
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PSSM-Id: 143375
Aligned: 3 rows
Threshold Bit Score: 628.15
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ####    #            # #               #             #              
EAW70296      97 FGAASSYLNLEKLGEGSYATVYKGISRIngQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTF 176 human
NP_001035398  78 FGNATSYLNLEKLGEGTYATVYKGISRIngHLVALKVIHMKTEEGIPFTAIREASLLKGLKHANIVLLHDIIHTRESLTF 157 zebrafish
XP_421941     65 FGAATSYVHLKKLCEGSSATVYKGISRIngQLVALKVISLETEEGVPFTAIREASLLKHLKHANIVLLHDIIQTKETLTF 144 chicken
Feature 1         ####  # ##                                    # # ## #          #  #           
EAW70296     177 VFEYMHTDLAQYMSQHPggLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTY 256 human
NP_001035398 158 VFEYVQTDLAQYMIQHPggLHSYNIRLFMFQLLRGLSYIHGRRILHRDLKPQNLLISYLGELKLADFGLARSKSIPCQTY 237 zebrafish
XP_421941    145 VLEYMHTDLAQYMAQHPggLHPCNVMLFMFQLLRGLAYIHRQHILHRDLKPQNLLISCLGELKLADFGLARAKSIPSQTY 224 chicken
Feature 1        # #### #                                     ##                                 
EAW70296     257 SSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVsnILEQLEKIWEVLGVPTEDTWPGVSkLPNYNP 336 human
NP_001035398 238 SAEVVTLWYRPPDVLMGSTDYSTALDIWGAGCIFIEMLQGSPAFPGVadVFEQLLKIWTVIGVPTEEIWPGVSdLPNYKP 317 zebrafish
XP_421941    225 SSEVVTLWYRPPDVLLGATDYSSDLDIWSAGCVFVEMVQGQPVFAGTssAPEQLEKIWTVLGVPTEDTWPGLSkLPKYKP 304 chicken
Feature 1                                                               
EAW70296     337 EWFPLPTPRS---LHVVWNRLGr-vPEAEDLASQMLKGFPRDRVSAQEALVHDYF 387 human
NP_001035398 318 EWFLPCKPQQ---FRDVWKRLSqlpYKTEDLAQQMLMMNPKDRISAQDALLHPYF 369 zebrafish
XP_421941    305 EIQKWSPCPLperLRVICDRLSr-aPAAEDLASRMLTAFPPGRISAQDALLHGFF 358 chicken

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