Conserved Protein Domain Family
STKc_BUR1

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cd07866: STKc_BUR1 (this model, PSSM-Id:143371 is obsolete and has been replaced by 270849)
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Bypass UAS Requirement 1 and similar proteins.
Serine/Threonine Kinases (STKs), Bypass UAS Requirement 1 (BUR1) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. BUR1, also called SGV1, is a yeast Cyclin-Dependent protein Kinase (CDK) that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin.
Statistics
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PSSM-Id: 143371
View PSSM: cd07866
Aligned: 11 rows
Threshold Bit Score: 532.276
Threshold Setting Gi: 45185408
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         ####    #            # #                #             #         
gi 74697003    17 FVGCsr-iaDYEVLGKLGEGTFGEVHRARSRktGALVALKKIIMHNErDGFPITALREIKLLKLLsHKNVLRLEEMAIeh 95
gi 32363142    27 FVGCsh-ltDYHLMEKLGEGTFGEVYKSQRRkdGKVYALKRILMHTEkEGFPITAIREIKILKSIkHENIIPLSDMTVvr 105
gi 74689025    30 FRDMsk-lrNYEIIQKLGQGTFGVVQKARNIktKELVALKQLINHSAkEGFPITAMREITILKKLnHKNILKIIDMIYee 108
gi 74689564    28 YYGCsnvteSYKPLGKIGEGTFGEVFRAEQIttKRHVALKKILLHSEkEGFPVTALREIRILKLLrHENVIPLVDLAVer 107
gi 71021733   598 FVGCss-ldDYEISIKLGQGTFGEVLKGRQIltGTQVALKKVTIHDAkDGLPITALREIKLLKKLrHPSVVPVIDMAFrp 676
gi 57228628   434 FGGSst-lmRYNMGTKLGEGTFGVVTKAVENdtKRAVALKKITQHNFrDGAHITTLREIKILKSLqHPNVVPLLNMVIsr 512
gi 116499913  234 FVGCgq-qsDYEVTTKLGEGTFGEVHKAIQKatGASVALKRILMHHEkEGMPVTALREIKILKALkHPCIVNILDMFVvr 312
gi 194707680   24 FQGCsk-isDFEFLEKLGEGTFGEVYKARCKrnGTVVALKKILMHNQkDGFPITALREIKLLKMLsHPNVLRLPEMAVek 102
gi 45185408    46 VYGVtkflgNYKEEKKLGQGTFGEVYRGVHLatQRQVAMKKILVKTEnDLFPITAQREITILKRLnHRNVVQLIEMVYdy 125
gi 238032395   16 FYGIsa-lrDYKIVGKLGEGTFGEVSKALQRrtGRVCALKKLMVLNSkDGFPITSFREVSILKKLkHKNVLQLVDMIYek 94
gi 6325419     50 VYGCtvfqnHYREDEKLGQGTFGEVYKGIHLetQRQVAMKKIIVSVEkDLFPITAQREITILKRLnHKNIIKLIEMVYdh 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      ####  # ##                                    # # #
gi 74697003    96 pprt--------------dkrtrpIVYMVTPYMDHDLSGLLDNPSVrFTEPQVKCYLLQLLEGLKYLHANHILHRDMKAA 161
gi 32363142   106 adkk---------------hrrrgSIYMVTPYMDHDLSGLLENPSVkFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAA 170
gi 74689025   109 pkisnp----------qdilhqrgCFYTVSPYMCSDLVGLLENPNInLEVSHIKCFMEQLLHGIQYIHEQMFLHRDIKAA 178
gi 74689564   108 gdqs---------------kkergCVYMVTPYMDHDLAGLLGNQSVqLSPAHIKCYMLQLLEGIGYLHAKKFLHRDIKAA 172
gi 71021733   677 sge----------------rgklgDVYMVEPYMDHDLNGMLENPSIrLEHSQIKLYMKQLLEGTLYLHKNRILHRDMKAA 740
gi 57228628   513 hdnhs------------entfiknEVFMVFPYMDHDLCGLLSNNDFkVNHSGAKCIMKQLLDGMAYIHSNNIIHRDIKTA 580
gi 116499913  313 sse-----------------kdplSVYMVFPYMDHDLAGLLENERVkLQPSQIKLYMKQLLEGTEYMHRNHILHRDMKAA 375
gi 194707680  103 skge---------------grkkpVMYMVMFYQEHDLAGLLENPNVhFTEPQIKCYMLQLLEGVRYLHESGILHRDMKAA 167
gi 45185408   126 ppaqngaaygqdssqasasadtmkSFYMILPYMVADLSGILHNPRVtLEMADIKNMMLQILEGINYIHCKKFMHRDIKTA 205
gi 238032395   95 pek----------------qespgIFYTVSPYMASDLTGLLNNPRVhLTQSQIKGIVYQMLEGINYVHQNHYFHRDIKAS 158
gi 6325419    130 spditn----------aassnlhkSFYMILPYMVADLSGVLHNPRInLEMCDIKNMMLQILEGLNYIHCAKFMHRDIKTA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #          #  #                             # #### #                          
gi 74697003   162 NLLINnkGVLQIADFGLARHYEGDIPQPGkgs-------geGKRDYTSLVVTRWYRPPELLMHLkrYTTAIDMWGVGCVF 234
gi 32363142   171 NLLIDnhGILKIADFGLARVITEESYANKnpgl-----pppNRREYTGCVVTRWYRSPELLLGErrYTTAIDMWSVGCIM 245
gi 74689025   179 NILIDrnGTLKIADFGLARVYHGSPPKFMsgp-------ggGERAYTGLVVTRWYRPPELLLGErrYTTAVDMWGIGCVF 251
gi 74689564   173 NILVNdqGILKLADFGLARGYDGPAPNSQta--------gvNTENLTAMVVTRWYRPPELILGDrkYTTAIDMWGIGCVF 244
gi 71021733   741 NLLIDnqGQLQIADFGLARPYRDPGQSWTgkg------wtaGTHRYTNMVVTRWYRPPELLAGEkkYGPPIDMWGIGCIL 814
gi 57228628   581 NILVDkhGQIMIADFGLARPWTDNKKMPPh-----------LATEYTNMVVTRWYRAPELLLGWcnYGPAVDIWSIGCVL 649
gi 116499913  376 NLLISntGNLRIADFGLARSFDTNITKGG------------STRKYTNCVVTRWYRPPELLLGArqYGGEVDIWGIGCVL 443
gi 194707680  168 NLLISnkGILQIADFGLARPYDEKPPQPGrgg-------geAKRDYTPLVVTRWYRPPELLLQLrrYTTAIDLWGVGCVF 240
gi 45185408   206 NILLDhkGILKIADFGLARNYYGAPPNLKypg------gagTDAKYTSVVVTRWYRAPELVLGDknYTTAVDIWGIGCVF 279
gi 238032395  159 NILIDsqGIVKIADFGLARIYYGPKPTPNggpggydsatgmGLASYTGLVVTRWYRPPELVLGEknYTTSVDIWGIGCIF 238
gi 6325419    200 NILIDhnGVLKLADFGLARLYYGCPPNLKypg------gagSGAKYTSVVVTRWYRAPELVLGDkqYTTAVDIWGVGCVF 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##                                                                   
gi 74697003   235 AEMLEgKPVLQGESDLHQLELVWDLCGTPSEETMPGWrTLPGGQa----------------FSSKPRPGNLAR-RFEKHg 297
gi 32363142   246 AEMYKgRPILQGSSDLDQLDKIFRLCGSPTQATMPNWeKLPGCEg---------------vRSFPSHPRTLET-AFFTFg 309
gi 74689025   252 GELFTrKPILVGKTDSHQAQLIFDLVGPPNSISWSEAtSLPNKHd---------------lNIGLTCQRSLES-KFAPLm 315
gi 74689564   245 GEFFTrKPIFPGASDVDQGSKIFQAVGVPTEDTMPGWsVLPGAQns--------------nIWGTDATNKLDK-LFGRLs 309
gi 71021733   815 AEMITgRPLFKGTSEINQLELIAKLCGSPNETNFPGWsSLPGVKdadptgrpdphpeipgqHAFGDYPRKVKD-HFRSVy 893
gi 57228628   650 GEMYLrRPILPGGGDREQLSMIFAKCGPLNEETWSGWqDLPGFPeahg----------fawDKTPRDTSILEEsKSWHMd 719
gi 116499913  444 GEMFNrRPILPGSSDLDQLEKIWYLCGTPTQHSWPNFdALPGCDgv--------------kHFKSNHIRRVKM-TYESVg 508
gi 194707680  241 GEMFKgRPILAGTSDLNQAQLIFSLVGSPTEETMPGYtSLPGCEg---------------vKDFGNKPGNLSQ-VFKEQg 304
gi 45185408   280 AEFFEkRPILQGKTDIDQGHVIFKLMGTPSDSDWQLArYLPGAE-----------------LTRTSYEPTYKE-RFGKYl 341
gi 238032395  239 AELFKrKPILEGKTEIDQGHLIFNLCGPLTPTSFPNAdKLPGYNn----------------YVSARYTRTLEQ-NYRKHl 301
gi 6325419    274 AEFFEkKPILQGKTDIDQGHVIFKLLGTPTEEDWAVArYLPGAE-----------------LTTTNYKPTLRE-RFGKYl 335
                         330       340       350
                  ....*....|....*....|....*....|...
Feature 1                                          
gi 74697003   298 ---PVVISLLKELFKLDWRSRINAIDALNHPYF 327
gi 32363142   310 ---KEMTSLCGAILTLNPDERLSASMALEHEYF 339
gi 74689025   316 --nPDGINLLSGLLTLDPYKRFNALDALNHNYF 346
gi 74689564   310 ---KDGLDFLKGLLLLDPTKRLTAIGGKNHAYF 339
gi 71021733   894 dagPGCADLIDKLLVLDPRKRLTAQQALEHEWF 926
gi 57228628   720 ---RGGADLLVKLLSLDPSKRPTASEALDHPWF 749
gi 116499913  509 ---AETADLLDKLLVCNPKERITAAQALEHEYF 538
gi 194707680  305 ---PLMISLLSEFLKLDWRKRITAVDALKHPYF 334
gi 45185408   342 --tEKGLDLLSTLLSLDPYKRLTAMAAMQHPFF 372
gi 238032395  302 --cSEGLRLLASLLEIDPVKRINALDALAHPYF 332
gi 6325419    336 --sETGLDFLGQLLALDPYKRLTAMSAKHHPWF 366

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