Conserved Protein Domain Family
STKc_TEY_MAPK

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cd07858: STKc_TEY_MAPK 
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143363
View PSSM: cd07858
Aligned: 16 rows
Threshold Bit Score: 659.447
Threshold Setting Gi: 66807963
Created: 24-Sep-2008
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #### ## #            # #                #             #            
gi 15218451   26 FEIDTKYMPIK-PIGRGAYGVVCSSVNSDTnEKVAIKKIHNVYENRIDALRTLRELKLLRHLRHENVIALKDVMMPihkm 104
gi 75321971   26 FEIDTKYVPIK-PIGRGAYGIVCSSINRATnEKVAIKKINNVFDNRVDALRTLRELKLLRHLRHENVIALKDIMMPvhrr 104
gi 2499614    26 FEIDTKYVPIK-PIGRGAYGIVCSSVNRETnEKVAIKKINNAFENRIDALRTLRELKLLRHLRHENVIALKDVMMPihrr 104
gi 18406388   26 FEIDTKYVPIK-PIGRGAYGVVCSSVNRESnERVAIKKIHNVFENRIDALRTLRELKLLRHLRHENVVALKDVMMAnhkr 104
gi 92700087   52 FECPAKYLPIK-PIGKGAYGVVCSAKNLDNqEKVAIKKIANAFDNVIDAKRTLREIKLLRHLQHENIVQIKDIIPPtnrd 130
gi 66807963  143 FTVPRRYSIVK-CIGHGAYGVVCSAKDNLTgEKVAIKKISKAFDNLKDTKRTLREIHLLRHFKHENLISIKDILKPnske 221
gi 116059852  95 FEVDAKYAPIK-PVGKGAYGVVCSAREVETnRKVAIKKIVNVFENVVDAKRTLREIKLLRHLRHENVIDIIDCVRPeamd 173
gi 168048183  26 FEIDTKYAPIK-PIGKGAYGVVCSAKNNETgDRVAIKKITNAFENTTDARRTLREIRLLRHLFHENIIAVKDIMKPvgrq 104
gi 2499610    56 FEVTAKYKPPImPIGKGAYGIVCSAMNSETnESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPplrn 135
gi 2499615    53 FEVTAKYKPPImPIGKGAYGIVCSALNSETnEHVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPpqre 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ####  # ##                                   # # ## #         ##  #     
gi 15218451  105 sFKDVYLVYELMDTDLHQIIKSSQVlSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARASN 184
gi 75321971  105 sFKDVYLVYELMDTDLHQIIKSSQPlSNDHCQYFLFQLLRGLKYLHSAGILHRDLKPGNLLVNANCDLKICDFGLARTNN 184
gi 2499614   105 sFKDVYLVYELMDTDLHQIIKSSQTlSNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTSS 184
gi 18406388  105 sFKDVYLVYELMDTDLHQIIKSSQVlSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARTSN 184
gi 92700087  131 aFKDLYVVYELMDTDLHQIIRSPQAlSNDHSQYFLYQLLRGLKYIHSANILHRDLKPSNLLVNANCDLKICDFGLARTST 210
gi 66807963  222 qFEDVYIVSELMDTDLHQIITSPQPlSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVED 301
gi 116059852 174 aFEDVYLMYDLMDTDLYQIIRSSQSlTDEHCQYFLYQILRGLKYIHSADVLHRDLKPGNLLLNANCDLKICDFGLARTAL 253
gi 168048183 105 tFNDVYIVYELMDTDLHQIIRSSQTlTDDHCQYFIYQLLRGLKYVHSANVLHRDLKPSNLLLNASCDLKICDFGLARTGS 184
gi 2499610   136 aFNDVYIAYELMDTDLHQIIRSNQAlSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS 215
gi 2499615   133 aFNDVYIAYELMDTDLHQIIRSNQGlSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # #### #                                      #                        
gi 15218451  185 TKg---QFMTEYVVTRWYRAPELLLCCDN-YGTSIDVWSVGCIFAELLGRKPIFQGTECLNQLKLIVNILGSQREEDl-e 259
gi 75321971  185 TK----GQFMTEYVVTRWYRAPELLLCCDnYGTSIDVWSVGCIFAELLGRKPIFPGTECLNQLKLIVNVLGTMSEADi-e 259
gi 2499614   185 GKd---QFMTEYVVTRWYRAPELLLCCDN-YGTSIDVWSVGCIFAELLGRKPVFPGTECLNQLKLIINILGSQREEDi-e 259
gi 18406388  185 TKg---QFMTEYVVTRWYRAPELLLCCDN-YGTSIDVWSVGCIFAELLGRKPVFPGTECLNQIKLIINILGSQREEDl-e 259
gi 92700087  211 SNe--kEFMTEYVVTRWYRAPELLLSCSG-YTTAIDVWSVGCIFAELLGRKPLFPGKDYVHQLSLITKVIGSPSEEEl-g 286
gi 66807963  302 ATh--qGFMTEYVATRWYRAPEVILSWNK-YTKAIDIWSVGCIFAELLGRKPLFQGKDYIHQITLIIETIGSPSEEDi-c 377
gi 116059852 254 VDaeasEFMTEYVVTRWYRAPELLLSCAE-YTSAIDVWSVGCIFAELLGRKTLFPGKDYVHQLNLIMRVIGTPRDDSeld 332
gi 168048183 185 DKg---QFMTEYVVTRWYRAPELLLSCDE-YTSAIDMWSVGCIFAELLGRKPLFPGKDYIHQLKLIISIIGSPDETDl-h 259
gi 2499610   216 ES----DFMTEYVVTRWYRAPELLLNSSD-YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEl-- 288
gi 2499615   213 ET----DFMTEYVVTRWYRAPELLLNSSD-YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEAEm-- 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 15218451  260 FIDNPKAKRYIRSLPYSPGMSLSRLYPGaHVLAIDLLQKMLVFDPSKRISVSEALQHPYMAPLYDPNANPpaqVPIDLDV 339
gi 75321971  260 FIDNPKARKYIKTLPYTPGIPLTSMYPQaHPLAIDLLQKMLVFDPSKRISVTEALEHPYMSPLYDPSANPpaqVPIDLDI 339
gi 2499614   260 FIDNPKARKYIKSLPYSPGTPFSRLYPHaHPLAIDLLQRMLVFDPSKRISVIEALQHPYMSPLYDPNTDPpaqVPINLDI 339
gi 18406388  260 FIDNPKAKRYIESLPYSPGISFSRLYPGaNVLAIDLLQKMLVLDPSKRISVTEALQHPYMAPLYDPSANPpaqVPIDLDV 339
gi 92700087  287 FITSEKAKRYIRSLPRSERVDFGQLWPHvTKTALDLIDKMLVFDPTKRITVEQALEHPYLASLHDVSDEPvcpTPFTFDF 366
gi 66807963  378 NIANEQARQFIRNMGNQPKVNFANMFPKaNPDAIDLLERMLYFDPSKRLTVEEALAHPYFQSLHDPSDEPiclHKFSLNF 457
gi 116059852 333 FINNEKARRYIKSLPVTARCNFRKLFPNaSPKAVDLVDKMLVLDPARRITVEDALAHPYLESLHDEVDEPcaeTPFTFNF 412
gi 168048183 260 FIQSQKARSYIRSLPFTPRVSLARLYPRaNPLAIQLIDKMLVFDPRKRITVHEALEHPYLSMLHDATVEPsapAPFEFDF 339
gi 2499610   289 EFLNENAKRYIRQLPPYPRQSITDKFPTvHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPectIPFNFDF 368
gi 2499615   286 EFLNENAKRYIRQLPLYRRQSFVEKFPHvNPAAIDLVEKMLTFDPRRRITVEDALAHPYLTSLHDISDEPvcmTPFNFDF 365
                        330       340
                 ....*....|....*....|....*
Feature 1                                 
gi 15218451  340 DEd---lREEMIREMMWNEMLHYHP 361
gi 75321971  340 DEn---lGVDMIREMMWQEMLHYHP 361
gi 2499614   340 DEd---lGEETIREMMWSEILEYHP 361
gi 18406388  340 DEde-dlGAEMIRELMWKEMIHYHP 363
gi 92700087  367 DSeh--lTPDVVREVILQDMAELHT 389
gi 66807963  458 EAwd--lNRDLLKELIYNEMLAYHP 480
gi 116059852 413 EEdgrylTGTDIRELIYTELCSLSD 437
gi 168048183 340 EDed--lKEDALRERVWNEMLFYHP 362
gi 2499610   369 ENha--lSEEQMKELIYREALAFNP 391
gi 2499615   366 EQha--lTEEQMKELIYREGLAFNP 388

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