Conserved Protein Domain Family
STKc_MAPK4_6

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cd07854: STKc_MAPK4_6 
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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Aligned: 7 rows
Threshold Bit Score: 606.776
Threshold Setting Gi: 70569439
Created: 27-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #### ## #            # #                 #             #            
2499596       14 FDLGSRYMDLKPLGCGGNGLVFSAVDNdcdKRVAIKKIVLTDp---QSVKHALREIKIIRRLDHDNIVKVFEILGpsgsq 90  human
NP_001025720  14 FDLGSRYMDLKPLGCGGNGLVFSAVDNdcdKRVAVKKIVLTDp---QSVKHALREIKIIRRLDHDNIVKVFEILGpsgsq 90  chicken
P31152        14 YDLGGRFVDFQPLGFGVNGLVLSAVDSracRKVAVKKIALSDa---RSMKHALREIKIIRRLDHDNIVKVYEVLGpkgtd 90  human
NP_001039017  14 FDLGPRYMDLKPLGYGGNGLVFSAVDTdcdKRVAVKKIVLTDp---QSVKHALREIKIIRRLDHDNIVKVFETLGpsgrr 90  zebrafish
AAH44411      13 FDLGAQYQDLRPLGTGASGLVLSALDRrsgLRVAVKKLVMRDa---VSVKHALREVKITRRLQHENVVRVYDVLGssghp 89  zebrafish
BAE06413      36 SDISSRYRDVYPLGCGSRALIFSAIDQqcrRRVAVKKIFVKQctpsHKLKQLIREIRILRKMDHDNIVRMYHALAssssr 115 Ciona intestinalis
XP_792156     15 HGIGSRFCDLRPLGYGSSGTVFSAVDSecdKSVAIKRVSLTDk---KSCKSALREIRILRKLQHENIVKIYDVIFdgnsd 91  purple sea urchin
Feature 1                                  ####  # ##                                  # # ## #  
2499596       91 ltd---------dvgsltelNSVYIVQEYMETDLANVLEQgpLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFIN 161 human
NP_001025720  91 ltd---------dvgsltelNCVYIVQEYMETDLANLLEQgpLLEDHARLFMYQLLRGLKYIHSANVLHRDLKPANLFIN 161 chicken
P31152        91 lq------------gelfkfSVAYIVQEYMETDLARLLEQgtLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFIS 158 human
NP_001039017  91 lte---------dvssltevNSVYIVQEYMETDLCKVLEQglLSEDHARLFMYQLLRGLKYIHSANVLHRDLKPANLFVN 161 zebrafish
AAH44411      90 lp------------rdlthvAAIYIVQECMETDLARLLEQgpLPAEHATLLFYQLLRGLKFIHSANVLHRDLKPANIFIN 157 zebrafish
BAE06413     116 dnsspvnmasnlslknqvsfDSVYIGMELMDTDLRNVINHnqLSSNYIKLFTYQLLRGLKYLHSANVIHRDLTPSNVFIN 195 Ciona intestinalis
XP_792156     92 nsed-------edisipselRTLCIVQELVDADLRVVMEQqrISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLIN 164 purple sea urchin
Feature 1                ##  #              # #### #                                     #       
2499596      162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQM 241 human
NP_001025720 162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQM 241 chicken
P31152       159 TEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQM 238 human
NP_001039017 162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQM 241 zebrafish
AAH44411     158 TEQMLLKIGDFGLARIVDPHYSHKGYLSEGMVTKWYRSPRLLLSPnnYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQM 237 zebrafish
BAE06413     196 TDTLMLKIGDFGISRILDSEYEHSGYLSMTTTSTWYQSPEILLHPrhYNQAADMWAAGCIFAEMLIGKPLFNGSNAMEQI 275 Ciona intestinalis
XP_792156    165 QEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPtdYTKAIDLWSAGCILAEMVTGKPLFPGDHDLELM 244 purple sea urchin
Feature 1                                                                                        
2499596      242 QLILESIPVVHEe----------DRQELLSVIPVYIRn-DMTEPHKPLTQLLPGiSREALDFLEQILTFSPMDRLTAEEA 310 human
NP_001025720 242 QLILESIPVVHEe----------DRQELLNVIPVYIRn-DMTEPHKPLTQLLPGiSPEALDFLEQILTFSPMDRLTAEEA 310 chicken
P31152       239 QLILETIPVIREe----------DKDELLRVMPSFVS--STWEVKRPLRKLLPEvNSEAIDFLEKILTFNPMDRLTAEMG 306 human
NP_001039017 242 QLILESIPVVHEe----------DRLELQSVIPVFIKn-DMSEPHTPLAKLLPGvSPEALDFLEKILTFNPMDRLTAEEA 310 zebrafish
AAH44411     238 QLILDTVPVIREe----------DRQELLRVMPSLVG--HGWQIRRSFRDLMPEvEDKAIDFLESILTFNPMDRLTAEAA 305 zebrafish
BAE06413     276 NLILKSVAVTREnwlsvttavcqDENCCLNKDAYNVRe-NGGIPRRPLRDLLPTsNHMAVNLLNQMLTFAQTDRVTAIDA 354 Ciona intestinalis
XP_792156    245 MLVLDSVQLNDR-----------DLNEILCTLPSKLLknYNGYPRHPLKEVLCNlDCHALDLLLAMLTFDPSERITAEEA 313 purple sea urchin
Feature 1                                                       
2499596      311 LSHPYMsIYSFPMDEPissHPFHIEDEVdd--iLLMDETHSHIYNWE 355 human
NP_001025720 311 LSHPYMsIYSFPTDEPissHPFHIEDEVdd--iLLMDESHSHIYNWE 355 chicken
P31152       307 LQHPYMsPYSCPEDEPtsqHPFRIEDEIdd--iVLMAANQSQLSNWD 351 human
NP_001039017 311 LAHPYMsDYSFPLDEPvslHPFHIEDEVdd--iLLMDESHSHVYNWD 355 zebrafish
AAH44411     306 LCQPFLqRYSCPQDEPvslQPFRIEDELedslvTESTHTHGLRSHWD 352 zebrafish
BAE06413     355 LMHPYLaCYSNPFDEPvcgMPFSLEDELd---eMDVTNIKQIIWNET 398 Ciona intestinalis
XP_792156    314 LRSPYFkVYSCIRDEAkatHPFHIENEId---dLPPIVIKKIILEEC 357 purple sea urchin

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