Conserved Protein Domain Family
STKc_MAPK4_6

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cd07854: STKc_MAPK4_6 
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143359
View PSSM: cd07854
Aligned: 7 rows
Threshold Bit Score: 606.776
Threshold Setting Gi: 70569439
Created: 27-Jul-2006
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #### ## #            # #                 #             #            
gi 2499596    14 FDLGSRYMDLKPLGCGGNGLVFSAVDNdcdKRVAIKKIVLTDp---QSVKHALREIKIIRRLDHDNIVKVFEILGpsgsq 90
gi 71895653   14 FDLGSRYMDLKPLGCGGNGLVFSAVDNdcdKRVAVKKIVLTDp---QSVKHALREIKIIRRLDHDNIVKVFEILGpsgsq 90
gi 215274102  14 YDLGGRFVDFQPLGFGVNGLVLSAVDSracRKVAVKKIALSDa---RSMKHALREIKIIRRLDHDNIVKVYEVLGpkgtd 90
gi 113930769  14 FDLGPRYMDLKPLGYGGNGLVFSAVDTdcdKRVAVKKIVLTDp---QSVKHALREIKIIRRLDHDNIVKVFETLGpsgrr 90
gi 27882123   13 FDLGAQYQDLRPLGTGASGLVLSALDRrsgLRVAVKKLVMRDa---VSVKHALREVKITRRLQHENVVRVYDVLGssghp 89
gi 70569439   36 SDISSRYRDVYPLGCGSRALIFSAIDQqcrRRVAVKKIFVKQctpsHKLKQLIREIRILRKMDHDNIVRMYHALAssssr 115
gi 390363388  15 HGIGSRFCDLRPLGYGSSGTVFSAVDSecdKSVAIKRVSLTDk---KSCKSALREIRILRKLQHENIVKIYDVIFdgnsd 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  ####  # ##                                  # # ## #  
gi 2499596    91 ltd---------dvgsltelNSVYIVQEYMETDLANVLEQgpLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFIN 161
gi 71895653   91 ltd---------dvgsltelNCVYIVQEYMETDLANLLEQgpLLEDHARLFMYQLLRGLKYIHSANVLHRDLKPANLFIN 161
gi 215274102  91 lq------------gelfkfSVAYIVQEYMETDLARLLEQgtLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFIS 158
gi 113930769  91 lte---------dvssltevNSVYIVQEYMETDLCKVLEQglLSEDHARLFMYQLLRGLKYIHSANVLHRDLKPANLFVN 161
gi 27882123   90 lp------------rdlthvAAIYIVQECMETDLARLLEQgpLPAEHATLLFYQLLRGLKFIHSANVLHRDLKPANIFIN 157
gi 70569439  116 dnsspvnmasnlslknqvsfDSVYIGMELMDTDLRNVINHnqLSSNYIKLFTYQLLRGLKYLHSANVIHRDLTPSNVFIN 195
gi 390363388  92 nsed-------edisipselRTLCIVQELVDADLRVVMEQqrISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLIN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ##  #              # #### #                                     #       
gi 2499596   162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQM 241
gi 71895653  162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQM 241
gi 215274102 159 TEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQM 238
gi 113930769 162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPnnYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQM 241
gi 27882123  158 TEQMLLKIGDFGLARIVDPHYSHKGYLSEGMVTKWYRSPRLLLSPnnYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQM 237
gi 70569439  196 TDTLMLKIGDFGISRILDSEYEHSGYLSMTTTSTWYQSPEILLHPrhYNQAADMWAAGCIFAEMLIGKPLFNGSNAMEQI 275
gi 390363388 165 QEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPtdYTKAIDLWSAGCILAEMVTGKPLFPGDHDLELM 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2499596   242 QLILESIPVVHEe----------DRQELLSVIPVYIRn-DMTEPHKPLTQLLPGiSREALDFLEQILTFSPMDRLTAEEA 310
gi 71895653  242 QLILESIPVVHEe----------DRQELLNVIPVYIRn-DMTEPHKPLTQLLPGiSPEALDFLEQILTFSPMDRLTAEEA 310
gi 215274102 239 QLILETIPVIREe----------DKDELLRVMPSFVS--STWEVKRPLRKLLPEvNSEAIDFLEKILTFNPMDRLTAEMG 306
gi 113930769 242 QLILESIPVVHEe----------DRLELQSVIPVFIKn-DMSEPHTPLAKLLPGvSPEALDFLEKILTFNPMDRLTAEEA 310
gi 27882123  238 QLILDTVPVIREe----------DRQELLRVMPSLVG--HGWQIRRSFRDLMPEvEDKAIDFLESILTFNPMDRLTAEAA 305
gi 70569439  276 NLILKSVAVTREnwlsvttavcqDENCCLNKDAYNVRe-NGGIPRRPLRDLLPTsNHMAVNLLNQMLTFAQTDRVTAIDA 354
gi 390363388 245 MLVLDSVQLNDR-----------DLNEILCTLPSKLLknYNGYPRHPLKEVLCNlDCHALDLLLAMLTFDPSERITAEEA 313
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
gi 2499596   311 LSHPYMsIYSFPMDEPissHPFHIEDEVdd--iLLMDETHSHIYNWE 355
gi 71895653  311 LSHPYMsIYSFPTDEPissHPFHIEDEVdd--iLLMDESHSHIYNWE 355
gi 215274102 307 LQHPYMsPYSCPEDEPtsqHPFRIEDEIdd--iVLMAANQSQLSNWD 351
gi 113930769 311 LAHPYMsDYSFPLDEPvslHPFHIEDEVdd--iLLMDESHSHVYNWD 355
gi 27882123  306 LCQPFLqRYSCPQDEPvslQPFRIEDELedslvTESTHTHGLRSHWD 352
gi 70569439  355 LMHPYLaCYSNPFDEPvcgMPFSLEDELd---eMDVTNIKQIIWNET 398
gi 390363388 314 LRSPYFkVYSCIRDEAkatHPFHIENEId---dLPPIVIKKIILEEC 357

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