1CM8,3COI,3GP0,1LEW,1LEZ,2FST,3HVC,2NPQ,1BL7,1ZZ2,3PY3,3NEW


Conserved Protein Domain Family
STKc_p38

?
cd07851: STKc_p38 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
?
PSSM-Id: 143356
View PSSM: cd07851
Aligned: 26 rows
Threshold Bit Score: 539.573
Threshold Setting Gi: 30315977
Created: 18-Jul-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1CM8_B; Human p38gamma binds MgAMP-PNP; defined at 4A contacts.
    View structure with Cn3D
  • Structure:3GP0_A; Human p38beta binds Nilotinib inhibitor; defined at 4A contacts.
    View structure with Cn3D
  • Structure:1ZZ2_A; Human p38alpha binds inhibitor; defined at 4A contacts.
    View structure with Cn3D
  • Structure:1BL7_A; Human p38alpha binds inhibitor SB220025; defined at 4A contacts.
    View structure with Cn3D
  • Citation:PMID 9753691

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                              ##   # ##                   # #                     #     
1CM8_B        11 FYRQEVtkTAWEVRAVYRDLQpVGSGAYGAVCSAVDGr-------tGAKVAIKKLYRPFQseLFAKRAYRELRLLKHMRH 83  human
CAQ34816       9 FVPVEInqLRWDLPDRYTPVNvAGQGSFGTVSSAFDKy-------lQREVAIKKLDRPFEnaEFAKRTYRELAILAQMDH 81  Echinococcus mu...
NP_001104637   9 FHRLDIqkTTWDVPDRYTSLKpVGSGAYGTVCFAVDQk-------tKEKVAIKKLYRPFQslIHAKRAYRELRLLRHIQH 81  zebrafish
Q17446        19 YYVVELnrSVWVVPNYYINLTpIGTGAYGTVCAAECTr-------sGTRVAIKKFNRPFQsiIHARRTYRELRLLRCMCH 91  nematode
AAH99322       9 FYRQDInkTKWEAPVRYRELAaVGSGAYGTVCSAQDRl-------tGERVAIKKLLRPFQslVHAKRAYRELRLLKHMKH 81  African clawed ...
3COI_A        10 FYKQDVnkTAWELPKTYVSPThVGSGAYGSVCSAIDKr-------sGEKVAIKKLSRPFQseIFAKRAYRELLLLKHMQH 82  human
XP_002111921  11 YYRCELnkTVWEIPIHYQNLSpIGSGAYGQVCSAIDTr-------tNIEIAIKKLSRPFEsnTFGKRTFREMKLLMHMNQ 83  Trichoplax adha...
XP_001638944   8 FYRTELvnTVYEVPRKYQELSpIGTGAYGQVCSSTITepdptnpdgPNTVAIKKLSRPFQstMHAKRTYRELKLLRHMRH 87  starlet sea ane...
P83100         4 FVRVAIneSLWEFPDIYEFVRfLGGGSFGQVAKVRLRg-------tENYFAMKRLMRPFEreEDAKGTYREIRLLKHMNH 76  fruit fly
XP_002137490   4 FTKFVMdeKAWEVPDVYEIERlLGAGSFGQVSKAKLRg-------gDVNVAIKKLLQPFEtaEHAKRVYREIRLLKHMDH 76  Drosophila pseu...
Feature 1           # #                    # ####  #                                     # # ##  
1CM8_B        84 ENVIGLLDVFTPdetl---ddfTDFYLVMPFMGTDLGKLMKheKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA 160 human
CAQ34816      82 ENVICLIDAFTPqtsl---etfEDVYLVTPLMDADLGAIVAqqVLTDDQICFLAYQMLRALKYMHGAHIIHRDLKPSNIG 158 Echinococcus mu...
NP_001104637  82 DNVICLLNVFTPdssl---ekfDTFYMVMPFVAQDLGHIMKrkQLTSNVITYLFYQILRGLKYIHSAGIIHRDLKPNNLA 158 zebrafish
Q17446        92 ENIIDLLDVFTPnenv---ndiEDVYFVSMLMGADLSNILKiqRLNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIA 168 nematode
AAH99322      82 ENVISLLNVFTPdesv---etfQTFYLVMPFIAVDLSRVMRmqRLNQSTIVYLLYQILRGLQYIHSAGIVHRDLKPSNLG 158 African clawed ...
3COI_A        83 ENVIGLLDVFTPassl---rnfYDFYLVMPFMQTDLQKIMGl-KFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 158 human
XP_002111921  84 EQVISLLDTFTPtsgr---snfSDVYLVTPLMGADLNTVIKcqPLSDDHVKFLVYQLMRGLKYIHSCRIIHRDLKPSNIA 160 Trichoplax adha...
XP_001638944  88 ENVISLLDVFTTasaf---ehfQDVYMVTELMGSDLNGILRfqKLSDEHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIA 164 starlet sea ane...
P83100        77 RNVISLLNVFHPpahn--mmefQQVYLVTHLMDADLHRYSRskRMSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIA 154 fruit fly
XP_002137490  77 PNVISLLDVFHPsspsptlenfQQVYLVTHLMDADLHKTIRsqKLSDNQIRVILYQILRALKYIHSAGVLHRDLKPGNIA 156 Drosophila pseu...
Feature 1                 ## #                                                                   
1CM8_B       161 VNEDCELKILDFGLARQADSEMXGXVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSdHLDQLKEIMK 240 human
CAQ34816     159 VNSDVELRIIDFGLARQKNHLMTGYVATRWYRAPEVMLNWMHYNDSVDVWSVACILVELKTRQPLFRGLnHIDQVKQIMS 238 Echinococcus mu...
NP_001104637 159 VDENCELKILDFGLARHTETEMTGYVVTRWYRAPEVIFNWMHYTQTVDVWTAGCILAEMITGEVLFPGSdSIDQLKKILN 238 zebrafish
Q17446       169 VNEDCELKILDFGLARQTDSEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSdHIDQLTRIMS 248 nematode
AAH99322     159 VNEDYELKILDFGLARQTEFEMTGYVVTRWYRAPEVILNWMHYNQTVDIWSVGCILAEMITGKVLFPGGdYFDELNRIIE 238 African clawed ...
3COI_A       159 VNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKdYLDQLTQILK 238 human
XP_002111921 161 VNENCELKILDFGLARKASEELTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEMLTSRPLFPGNdHIDQLTRILE 240 Trichoplax adha...
XP_001638944 165 VNEDCELKILDFGLARMTDAEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTSKTLFPGNdHIDQLTKIMQ 244 starlet sea ane...
P83100       155 VNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITDRVLFRGEnYVSQIRCLIN 234 fruit fly
XP_002137490 157 VNKDCELRILDFGMARLNSKDMTTYVTTRWYRAPEILFCWRNYSKAIDMWSVGCIFAEMITGRPLFPGRdYTNQLDCIID 236 Drosophila pseu...
Feature 1                                                                                        
1CM8_B       241 VTGTPPAEFVQRLqsDEAKNYMKGLPELEKKDFASILTNaSPLAVNLLEKMLVLDAEQRVTAGEALAHPYFe----SLHD 316 human
CAQ34816     239 IVGAPDEELMQKItsSSAREFIEKLNYTSKKDLKDAFPWaSPVLLDLLSKMLVLDPDRRLTAAQALAHPYFa----EYHN 314 Echinococcus mu...
NP_001104637 239 LTGTPNSTLVLKMqsKDAQSYVRSLPVQKKKAFKEVFSGmDPNAIDLLEGMLVLDPEVRLSAKNGLSHPYLs----EFHD 314 zebrafish
Q17446       249 VTGTPDEEFLKKIssEEARNYIRNLPKMTRRDFKRLFAQaTPQAIDLLEKMLHLDPDRRPTAKEAMEHEYLa----AYHD 324 nematode
AAH99322     239 VTGSPQPSLINKMesSHAQDYVRMLPKKQKKNFKELFPTmSSIETELLEKMLDLDPEKRINATEALAHPYLe----EYND 314 African clawed ...
3COI_A       239 VTGVPGTEFVQKLndKAAKSYIQSLPQTPRKDFTQLFPRaSPQAADLLEKMLELDVDKRLTAAQALTHPFFe----PFRD 314 human
XP_002111921 241 LVGCPSDEFIRKIqsEAARNYVAGMPKFPRKDFSTVFLGaNPEAIDLLEKMLTLDSSQRIDAIEALAHPYLa----EYAD 316 Trichoplax adha...
XP_001638944 245 LVGKPSDDFLQKIdsESARNYIAQMPDYRKTPFDEYFVGaNPLAVDLLEKMLNLDTDHRITAVEALSHPYLa----SYAD 320 starlet sea ane...
P83100       235 IMGTPTREFITGIsmERSRNYLEGYPLRQRCDFHHLFMGyDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLrdliePHHH 314 fruit fly
XP_002137490 237 IMGTPSDEFKSKIdlESARTYVESLPRRTKSDFMELFGMgNYQAVDLIEKMLVMDPDNRITADEALRHPFLknlvqPQHN 316 Drosophila pseu...
Feature 1                                               
1CM8_B       317 TEDEPq-vQKYDDSFDDv-dRTLDEWKRVTYKEVLSFKP 353 human
CAQ34816     315 ESDEPvgePLEDDLIDSd-nLTMEEWKEATWNLLQNFKP 352 Echinococcus multilocularis
NP_001104637 315 PENEPv-sPPYDDSFESm-dLAVSEWKSLIHMEIMTFDP 351 zebrafish
Q17446       325 ETDEPi-aEEMDLNDDVr-aDTIDEWKKIIWEEISDFQK 361 nematode
AAH99322     315 SDPDPp-aEKYDDSFESl-dLDVHEWKSLSHMEIMTFEP 351 African clawed frog
3COI_A       315 PEEETeaqQPFDDSLEHe-kLTVDEWKQHIYKEIVNFSP 352 human
XP_002111921 317 PDDEPs-gEPFDEGFEDl-eISVEQWKDMVYKQIEEFKR 353 Trichoplax adhaerens
XP_001638944 321 PNDEPt-cSTFDDSFDEk-eLSIEGWRALVYQEILDFQQ 357 starlet sea anemone
P83100       315 AEDTA---PVYDQNFENm-vLPVKCWKELVSHEIRNFRP 349 fruit fly
XP_002137490 317 DEDTA---PLYDQNFENmdwLSVKCWKELVLNEIMNFRP 352 Drosophila pseudoobscura pseudoobscura

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap