Conserved Protein Domain Family
STKc_PCTAIRE_like

?
cd07844: STKc_PCTAIRE_like (this model, PSSM-Id:143349 is obsolete and has been replaced by 270835)
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), PCTAIRE-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this subfamily share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events.
Statistics
?
PSSM-Id: 143349
Aligned: 13 rows
Threshold Bit Score: 577.025
Created: 31-Jul-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                     ####    #            # #               #             #              
266425        159 FGKLETYIKLDkLGEGTYATVYKGKSKLtdNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTL 238  human
O94921        129 FGKADSYEKLEkLGEGSYATVYKGKSKVngKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTL 208  human
CAA67862      186 FGKQEAYVKLEpLGEGSYATVYKGFSKLtyQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTF 265  fruit fly
O35831        186 FGKMETYIKLEkLGEGTYATVYKGRSKLteNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTL 265  Norway rat
XP_001640180    5 YGKMETYTKLDkLGEGTYATVFKGKSKLtdNIVALKEIRLEHEEGAPCTAIREVSLLKGLKHANIVTLHDTVHTQKSLTL 84   starlet sea a...
XP_782022      51 FGKVETYKKICpLGEGSYAKVYKAVSCInqQVVALKEIRLQQDEGTPFTAIREASLLKDLKHANIVCLHDIIHTKTTLSF 130  purple urchin
Q07002        136 FGKLETYVKLDkLGEGTYATVFKGRSKLteNLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTL 215  human
CAZ33684      603 FGCVDSYQKLDvLGEGSYATVYRGYSHVmrRAVAVKEIRINPEEGLPFTAIREASLLKALRHANIVILHDIVHTKKTLNF 682  Schistosoma m...
XP_002407369  100 FGKMETYTKLDkLGEGTYAMVFKGKSRLtdNLVALKEIRLEHEEGAPCTAIREVSLLKDLRHNNIVTLHDIVHTEKSLTL 179  black-legged ...
EAW70296       97 FGAASSYLNLEkLGEGSYATVYKGISRIngQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTF 176  human
XP_002108187    5 FGKLESYDKLHkLGEGTYATVFKGRSKLtnDFVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDTIHTERSLVL 84   Trichoplax ad...
AAB00656      232 FGKLETYEKLDkLGEGTYATVFRGRSILtnKFVALKEIRLEQEEGAPCTAIREVSLLRNLRHANVVTLHDIIHTDRLLTL 311  nematode
XP_002131308  112 YGKLETYKKLGvLGEGSYATVYKGQSKHtgQLVALKEISLNAEEGAPFTAIREASLLKTLKHANIITLHDIVHATTTLTL 191  Ciona intesti...
Feature 1          ####  # ##                                     # # ## #          #  #          
266425        239 VFEYLDKDLKQYLDDCGn-iINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKT 317  human
O94921        209 VFEYVHTDLCQYMDKHPg-gLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHT 287  human
CAA67862      266 VFEYCDTDLSQYMEKHPg-gLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHT 344  fruit fly
O35831        266 VFEYLDKDLKQYMDDCGs-iMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKT 344  Norway rat
XP_001640180   85 VFEYLEKDLKQYMDDCGg-iMSMNNVRIFLFQLLRGLDYCHKRKVLHRDLKPQNLLINDKGELKLADFGLARAKSVPTKT 163  starlet sea a...
XP_782022     131 VFEYVHTDLSTYLERHPg-gLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRT 209  purple urchin
Q07002        216 VFEYLDSDLKQYLDHCGn-lMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKT 294  human
CAZ33684      683 IFEFVQSDLSKYIENHPr-gIKLHNVRLFLYQLLRGLAYCHDRHILHRDLKPQNLLISIQGELKLADFGLARAKSVPSRT 761  Schistosoma m...
XP_002407369  180 VFEYLEKDLKQYMDDCGn-fLSMNNVKCFLFQLLRGLAYCHGRRILHRDLKPQNLLINERGELKLADFGLARAKSVPIKT 258  black-legged ...
EAW70296      177 VFEYMHTDLAQYMSQHPg-gLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQT 255  human
XP_002108187   85 VFEYLDRDLKQYMDSCGs-iLDMSNVKIFLFQLLRGLAYCHSRRVLHRDLKPQNLLINERGELKLADFGLARAKSVPSKT 163  Trichoplax ad...
AAB00656      312 VFEYVDRDLKQYMDSCNn-aMQMNNIRLFLYQLLRGLAYCHQRRVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKT 390  nematode
XP_002131308  192 VFEYMVTDLSTYMEWYGscgIHPSNAVLFTFQLLRGLDYCHQRRILHRDLKPQNLLLSDLGELKLADFGLARAKSIPTNT 271  Ciona intesti...
Feature 1          # #### #                                     ##                                
266425        318 YSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSt-VEEQLHFIFRILGTPTEETWPGIl--sNEE 394  human
O94921        288 YSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMkdIQDQLERIFLVLGTPNEDTWPGVh--sLPH 365  human
CAA67862      345 YSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIrdTYDQLDKIFKLLGTPTEDTWPGVt--hFPG 422  fruit fly
O35831        345 YSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSt-VEDELHLIFRLLGTPSQETWPGVs--sNDE 421  Norway rat
XP_001640180  164 YSNEVVTLWYRPPDVLLGSTAYSTQIDMWGVGCIFFEMATGRPLFPGSt-VEDELLLIFKVLGTPSEEVWPGIs--aNEA 240  starlet sea a...
XP_782022     210 YSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEMMWGQPAFPGLkdATDQLEKIFKVLGTPTEQTWHGVsrlpNYG 289  purple urchin
Q07002        295 YSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSt-VKEELHLIFRLLGTPTEETWPGVt--aFSE 371  human
CAZ33684      762 YSHEVVTLWYRPPDVLLGSTCYTASLDIWGVGCIFTEMISGVATFPGSkdSVDQLDKIFRVMGTPCEETWPGVs--kLPK 839  Schistosoma m...
XP_002407369  259 FSNEVVTLWYRPPDVLLGSTDYSTSIDMWGVGCIFYEMASGRPLFPGSt-VEDELHLIFRSLGTPTEATWPGIe--sRAE 335  black-legged ...
EAW70296      256 YSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVsnILEQLEKIWEVLGVPTEDTWPGVs--kLPN 333  human
XP_002108187  164 YSSEVVTLWYRPPDVLLGSTEYSTSIDMWGVGCIFYEMATGLPMFPGSs-TENQLQTIWEILGTPTEEEWSGLt--rNLK 240  Trichoplax ad...
AAB00656      391 YSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMIAGRALFPGGt-PTEQLGLIFRTLGSPRPDRHPTIc--eKPT 467  nematode
XP_002131308  272 YSNEVVTLWYRPPDVLLGSRNYTTSLDMWGVGCIFLEMLTGMPVFPGHsdANDQLTKIFKVLGTPTPQTWRKLp--sFPC 349  Ciona intesti...
Feature 1                                                                  
266425        395 FKTYNYPKYRAEA---LLSHAPRLd--SDGADLLTKLLQFEGRNRISAEDAMKHPFF 446  human
O94921        366 FKPERFTLYSSKN---LRQAWNKLsyvNHAEDLASKLLQCSPKNRLSAQAALSHEYF 419  human
CAA67862      423 YKPHKLGFYRPRK---LGHNFPRLydiIEGETIANGFLQLNPEQRLGADDALQHPYF 476  fruit fly
O35831        422 FKNYNFPKYKPQP---LINHAPRLd--SEGIELITKFLQYESKKRAPAEEAMKHVYF 473  Norway rat
XP_001640180  241 FIAGKFPDYPREN---LIIHAPRLd--NSGLELLEKFLEYTVKDRVSAHDAMRHDYF 292  starlet sea anemone
XP_782022     290 KVAAAGRFHKPKL---LCEILPSIlliPGAESLMTDMLQLEPRKRISTVQAMTCQYF 343  purple urchin
Q07002        372 FRTYSFPCYLPQP---LINHAPRLd--TDGIHLLSSLLLYESKSRMSAEAALSHSYF 423  human
CAZ33684      840 YKTLRLHFYPNRP---LHRVISRLsraPHAESLALQFLQLQPSKRISARAAMRSAYF 893  Schistosoma mansoni
XP_002407369  336 FVAYHFPRYAPEP---LGSRVPRIg--SSGAALLLDFLKFEPRARVSAAEAMRHSYF 387  black-legged tick
EAW70296      334 YNPEWFPLPTPRS---LHVVWNRLgrvPEAEDLASQMLKGFPRDRVSAQEALVHDYF 387  human
XP_002108187  241 VNSLSFHDCKGEP---LRNRAPRLe--ADGLDLLAKFLQYKAKSRISSADAMKHKYF 292  Trichoplax adhaerens
AAB00656      468 FYPYANRHYNPDP---LCRQIPRId--AHGFELLMKFLQYEGKDRVSAAEAVKHPFL 519  nematode
XP_002131308  350 YEDYSSCFTPVRNrvtFDETFTKIsriEFGVEFALDLLQFEPDNRLSGAEALHHPIF 406  Ciona intestinalis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap