1UA2


Conserved Protein Domain Family
STKc_CDK7

?
cd07841: STKc_CDK7 (this model, PSSM-Id:143346 is obsolete and has been replaced by 270833)
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 7 (CDK7) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation.
Statistics
?
Aligned: 29 rows
Threshold Bit Score: 444.711
Threshold Setting Gi: 1695919
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structure of human CDK7 bound with ATP

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                #### ## #             # #                            #              #   
1UA2_D        11 RYEKLDF-LGEGQFATVYKARDKNT-NQIVAIKKIKLGHRse---------akDGINRTALREIKLLQELs-HPNIIGLL 78  human
Q12126        10 TYVKERK-VGEGTYAVVFLGRQKET-NRRVAIKKIKVGQFk------------DGIDISALREIKFLRESr-HDNVIELV 74  Schizosaccharom...
XP_960739     62 KYIKGKK-LGEGTYANVYLGHSRLDsSTQVAIKKIKVQKEy-----------qDGIAPDAIREMKYLQKLrgHANIIILH 129 Neurospora cras...
XP_001939125  22 QFVMGAK-LGEGTYAIVWQAHYRDNpKHVVAIKKIKVNAEy-----------pNGIAPDAIREMQFLFELs-HPNVIKLH 88  Pyrenophora tri...
125399         6 EYTKEKK-VGEGTYAVVYLGCQHST-GRKIAIKEIKTSEFk------------DGLDMSAIREVKYLQEMq-HPNVIELI 70  baker's yeast
AAW47177      12 RWDKGIK-IGEGTFANVYKGTEKAT-GRKVAIKKIKVGEMk------------HGLDMTALREVKFLQELk-HPNIISLL 76  Cryptococcus ne...
XP_502400      8 KYTKDKK-VGEGTFAVVYVGKQVKT-DRKIAIKQIKEGEFk------------DGVDMSAIREIKFLQEIr-HANVIELI 72  Yarrowia lipoly...
EAU90613      14 KWLKDRK-VGEGAYAVVYQGREAST-GRKVAIKKIKVGQFk------------DGLDMSAIREVKFLRELk-HQNVIELL 78  Coprinopsis cin...
XP_665899      7 RYEQINAhIGQGTYGKVEKAIDKNS-DTIVAIKKVKICELpsdltesrqkvgqCGIHFTVLREIKIMNEIn-HPNIMGLR 84  Cryptosporidium...
XP_002177995   3 NYKVLSA-LGQGTWGVVHKAEQKLS-GRVVAIKKIKSERPe------------EGVNFTAVREIKLLREFr-HENIVELV 67  Phaeodactylum t...
Feature 1                     ####   # ##                                     # # ## #          #
1UA2_D        79 DAFGH-KSNISLVFDFM-ETDLEVIIKDns-lvLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDenGVLKLAD 155 human
Q12126        75 DVFST-KSNLNIILEFL-DSDLEMLIKDkf-ivFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISsdGVLKLAD 151 Schizosaccharom...
XP_960739    130 SVFSSkDQNLNLVLEYLpLGDLEMLIRDvdhvrYGAADIKAWMGMLTRAIWWCHDNYVLHRDIKPNNLLIAadGEVKLAD 209 Neurospora cras...
XP_001939125  89 AVFSSrDQNLSLVLEHLpRGDLEQLWKNke-itYTKADIKAWMNMMCQGIWFCHENYVLHRDIKGSNALIAadGTVKIAD 167 Pyrenophora tri...
125399        71 DIFMA-YDNLNLVLEFL-PTDLEVVIKDks-ilFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSpdGQIKVAD 147 baker's yeast
AAW47177      77 DVFSV-KQNINLVLEFL-DTDLEAVIRDka-liFQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAanGELKIAD 153 Cryptococcus ne...
XP_502400     73 DVFTA-GPRLSMVLEFL-PTDLEGLIKDtk-ilFRLGDVKAWMLMATRGLHHCHRLQILHRDLKPNNLLISptGELKIAD 149 Yarrowia lipoly...
EAU90613      79 DVFSS-KKNLNLVLEFL-DTDLEIIIRDrs-lvFLPADIKSWMAMTFRGLEFCHRNWILHRDLKPNNLLIAsdGQLKIAD 155 Coprinopsis cin...
XP_665899     85 DVFVQ-GDFINLVMDYM-ESDLRKVFENri--rFSESHIKCLLKQIILGINELHNWFIIHRDLAPANIFINskGIAKVGD 160 Cryptosporidium...
XP_002177995  68 DCFTTpDQAVCLVYECA-FTDLEKILGNks-isISLADTKQHLLSLLRAISACHDRWILHRDLKPDNMLFLedGTMKLAD 145 Phaeodactylum t...
Feature 1          # #         # #### #                                      ##                  
1UA2_D       156 FGLAKSFGSPnRAYXHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDsDLDQLTRIFETLGTPTE 234 human
Q12126       152 FGLSRDFGTP-SHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLR-TPYLPGEsDLDQLNVIFRALGTPEP 229 Schizosaccharom...
XP_960739    210 FGLARSFADPgVRMTANVITRWYRPPELLFGARHYSGAVDIWSVGLVFAELIIR-APYLPGNsEVEQIALICREIGTPTE 288 Neurospora cras...
XP_001939125 168 FGLARSFADPgTKMTTMVITRMYRPLELLYGCSHYGGTADMWSIGVLMAELCKR-DWFLYSDtDIRQVSVICEKFGTPTE 246 Pyrenophora tri...
125399       148 FGLARAIPAPhEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLR-IPYLPGQnDVDQMEVTFRALGTPTD 226 baker's yeast
AAW47177     154 FGLAREFGDAgNKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILR-VPFLAGEtDIDQLKKTFHAMGTPTE 232 Cryptococcus ne...
XP_502400    150 FGLARQMPNPkDKMTPTVVTRWYRAPELLFGARYYTPAVDVWSLGLIFAELMLR-LPYCPGEdDIDQIDKTFRAFGTPTE 228 Yarrowia lipoly...
EAU90613     156 FGLARDFADPgYKMTCQVITRWYRPPELLYGCRYYGTGVDIWSVGCIFAELMLR-IPYLAGEsDMDQLKTIFRALGTPTE 234 Coprinopsis cin...
XP_665899    161 FGLARSYGQPrREYTPEVVTLWYRCPELLFGSTKYTHAVDMWSIGCIFAELLTGgKALLPGDdEVRQLGHIFELLGTPNE 240 Cryptosporidium...
XP_002177995 146 FGLARMHGTPkTRLSPQAITLWYKPPELLLGASEYSSSADMWSVGCIFAELLLR-RPFLQGQtDLSQLDTIFTVFGTPNE 224 Phaeodactylum t...
Feature 1                                                                                        
1UA2_D       235 EQWPDMCSlp---dYVTFKSFPGIPL-------------HHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSnR 298 human
Q12126       230 EVIKSMQQlp---nYVEMKHIPPPNGg-----------mEALFSAAGHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSaL 295 Schizosaccharom...
XP_960739    289 ENWPGVTQlkeytvPSDVVPVAGKDKy------------MGRFGAVGSDGVDLLTKTLVLDPRRRITAREMLEHRWWKaD 356 Neurospora cras...
XP_001939125 247 DTWPGVSAlp---yYVAPDKQTGPQGttafrqtrprswwKQEFPTLGDDGCDFIKGLLTLDPQKRYTARKALEDKWWAnA 323 Pyrenophora tri...
125399       227 RDWPEVSSfm---tYNKLQIYPPPSRde----------lRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKeL 293 baker's yeast
AAW47177     233 QDWPGYTKlp---dYHEVGSFPKNPW-------------WNMISSIGREGQDLARELLRFDPAQRPSAKKALLHSFFTsY 296 Cryptococcus ne...
XP_502400    229 EEWPGLTSlp--ayPKTVNKYPHPSVqe----------lKMRFSAATENGLELFQAMTELNPADRVSCEEALTADYFTeF 296 Yarrowia lipoly...
EAU90613     235 EEWPGHTKlp---dYVPVGQFPKTPL-------------RDLFTAASADALNLLSKCLVYEPRKRISAREALNHPYFFaL 298 Coprinopsis cin...
XP_665899    241 DNWPQAKElp---lYCEFSPRSPLNF-------------KDIFPNASEMAIDLIQSLLRLNPLERISASQALEHEYFKsY 304 Cryptosporidium...
XP_002177995 225 TNWADFQTlplctrGLEWDETTAIPF-------------DEIFTAAPKDAISLLRSILVLDPNMRFTATQCLSHPYFSnD 291 Phaeodactylum t...
Feature 1                  
1UA2_D       299 PGPTPGCQLP 308 human
Q12126       296 PKPTHPSLLP 305 Schizosaccharomyces pombe
XP_960739    357 PKPTPKHDLP 366 Neurospora crassa OR74A
XP_001939125 324 PRPTKKENLP 333 Pyrenophora tritici-repentis Pt-1C-BFP
125399       294 PPPSDPSSIK 303 baker's yeast
AAW47177     297 PPPTPPIALP 306 Cryptococcus neoformans var. neoformans JEC21
XP_502400    297 PRPTKLAELP 306 Yarrowia lipolytica CLIB122
EAU90613     299 PYPTHPSKLP 308 Coprinopsis cinerea okayama7#130
XP_665899    305 PLPCDPSELP 314 Cryptosporidium hominis TU502
XP_002177995 292 PVPTLKEKLV 301 Phaeodactylum tricornutum CCAP 1055/1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap