1UA2


Conserved Protein Domain Family
STKc_CDK7

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cd07841: STKc_CDK7 (this model, PSSM-Id:143346 is obsolete and has been replaced by 270833)
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 7 (CDK7) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation.
Statistics
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PSSM-Id: 143346
View PSSM: cd07841
Aligned: 29 rows
Threshold Bit Score: 444.711
Threshold Setting Gi: 1695919
Created: 24-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structure of human CDK7 bound with ATP

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #### ## #             # #                            #              #   
1UA2_D        11 RYEKLDF-LGEGQFATVYKARDKNT-NQIVAIKKIKLGHRse---------akDGINRTALREIKLLQELs-HPNIIGLL 78
gi 26392384   10 TYVKERK-VGEGTYAVVFLGRQKET-NRRVAIKKIKVGQFk------------DGIDISALREIKFLRESr-HDNVIELV 74
gi 85099231   62 KYIKGKK-LGEGTYANVYLGHSRLDsSTQVAIKKIKVQKEy-----------qDGIAPDAIREMKYLQKLrgHANIIILH 129
gi 189205581  22 QFVMGAK-LGEGTYAIVWQAHYRDNpKHVVAIKKIKVNAEy-----------pNGIAPDAIREMQFLFELs-HPNVIKLH 88
gi 125399      6 EYTKEKK-VGEGTYAVVYLGCQHST-GRKIAIKEIKTSEFk------------DGLDMSAIREVKYLQEMq-HPNVIELI 70
gi 57230868   12 RWDKGIK-IGEGTFANVYKGTEKAT-GRKVAIKKIKVGEMk------------HGLDMTALREVKFLQELk-HPNIISLL 76
gi 50549857    8 KYTKDKK-VGEGTFAVVYVGKQVKT-DRKIAIKQIKEGEFk------------DGVDMSAIREIKFLQEIr-HANVIELI 72
gi 116507718  14 KWLKDRK-VGEGAYAVVYQGREAST-GRKVAIKKIKVGQFk------------DGLDMSAIREVKFLRELk-HQNVIELL 78
gi 67594819    7 RYEQINAhIGQGTYGKVEKAIDKNS-DTIVAIKKVKICELpsdltesrqkvgqCGIHFTVLREIKIMNEIn-HPNIMGLR 84
gi 219112487   3 NYKVLSA-LGQGTWGVVHKAEQKLS-GRVVAIKKIKSERPe------------EGVNFTAVREIKLLREFr-HENIVELV 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     ####   # ##                                     # # ## #          #
1UA2_D        79 DAFGH-KSNISLVFDFM-ETDLEVIIKDns-lvLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDenGVLKLAD 155
gi 26392384   75 DVFST-KSNLNIILEFL-DSDLEMLIKDkf-ivFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISsdGVLKLAD 151
gi 85099231  130 SVFSSkDQNLNLVLEYLpLGDLEMLIRDvdhvrYGAADIKAWMGMLTRAIWWCHDNYVLHRDIKPNNLLIAadGEVKLAD 209
gi 189205581  89 AVFSSrDQNLSLVLEHLpRGDLEQLWKNke-itYTKADIKAWMNMMCQGIWFCHENYVLHRDIKGSNALIAadGTVKIAD 167
gi 125399     71 DIFMA-YDNLNLVLEFL-PTDLEVVIKDks-ilFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSpdGQIKVAD 147
gi 57230868   77 DVFSV-KQNINLVLEFL-DTDLEAVIRDka-liFQNADIKSWMAMSLRGLEYIHRNGVLHRDLKPNNLLIAanGELKIAD 153
gi 50549857   73 DVFTA-GPRLSMVLEFL-PTDLEGLIKDtk-ilFRLGDVKAWMLMATRGLHHCHRLQILHRDLKPNNLLISptGELKIAD 149
gi 116507718  79 DVFSS-KKNLNLVLEFL-DTDLEIIIRDrs-lvFLPADIKSWMAMTFRGLEFCHRNWILHRDLKPNNLLIAsdGQLKIAD 155
gi 67594819   85 DVFVQ-GDFINLVMDYM-ESDLRKVFENri--rFSESHIKCLLKQIILGINELHNWFIIHRDLAPANIFINskGIAKVGD 160
gi 219112487  68 DCFTTpDQAVCLVYECA-FTDLEKILGNks-isISLADTKQHLLSLLRAISACHDRWILHRDLKPDNMLFLedGTMKLAD 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # #         # #### #                                      ##                  
1UA2_D       156 FGLAKSFGSPnRAYXHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDsDLDQLTRIFETLGTPTE 234
gi 26392384  152 FGLSRDFGTP-SHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLR-TPYLPGEsDLDQLNVIFRALGTPEP 229
gi 85099231  210 FGLARSFADPgVRMTANVITRWYRPPELLFGARHYSGAVDIWSVGLVFAELIIR-APYLPGNsEVEQIALICREIGTPTE 288
gi 189205581 168 FGLARSFADPgTKMTTMVITRMYRPLELLYGCSHYGGTADMWSIGVLMAELCKR-DWFLYSDtDIRQVSVICEKFGTPTE 246
gi 125399    148 FGLARAIPAPhEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLR-IPYLPGQnDVDQMEVTFRALGTPTD 226
gi 57230868  154 FGLAREFGDAgNKMTCQVITRWYRPPELLFGSRYYSPTVDIWSMGTIFVELILR-VPFLAGEtDIDQLKKTFHAMGTPTE 232
gi 50549857  150 FGLARQMPNPkDKMTPTVVTRWYRAPELLFGARYYTPAVDVWSLGLIFAELMLR-LPYCPGEdDIDQIDKTFRAFGTPTE 228
gi 116507718 156 FGLARDFADPgYKMTCQVITRWYRPPELLYGCRYYGTGVDIWSVGCIFAELMLR-IPYLAGEsDMDQLKTIFRALGTPTE 234
gi 67594819  161 FGLARSYGQPrREYTPEVVTLWYRCPELLFGSTKYTHAVDMWSIGCIFAELLTGgKALLPGDdEVRQLGHIFELLGTPNE 240
gi 219112487 146 FGLARMHGTPkTRLSPQAITLWYKPPELLLGASEYSSSADMWSVGCIFAELLLR-RPFLQGQtDLSQLDTIFTVFGTPNE 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1UA2_D       235 EQWPDMCSlp---dYVTFKSFPGIPL-------------HHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSnR 298
gi 26392384  230 EVIKSMQQlp---nYVEMKHIPPPNGg-----------mEALFSAAGHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSaL 295
gi 85099231  289 ENWPGVTQlkeytvPSDVVPVAGKDKy------------MGRFGAVGSDGVDLLTKTLVLDPRRRITAREMLEHRWWKaD 356
gi 189205581 247 DTWPGVSAlp---yYVAPDKQTGPQGttafrqtrprswwKQEFPTLGDDGCDFIKGLLTLDPQKRYTARKALEDKWWAnA 323
gi 125399    227 RDWPEVSSfm---tYNKLQIYPPPSRde----------lRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKeL 293
gi 57230868  233 QDWPGYTKlp---dYHEVGSFPKNPW-------------WNMISSIGREGQDLARELLRFDPAQRPSAKKALLHSFFTsY 296
gi 50549857  229 EEWPGLTSlp--ayPKTVNKYPHPSVqe----------lKMRFSAATENGLELFQAMTELNPADRVSCEEALTADYFTeF 296
gi 116507718 235 EEWPGHTKlp---dYVPVGQFPKTPL-------------RDLFTAASADALNLLSKCLVYEPRKRISAREALNHPYFFaL 298
gi 67594819  241 DNWPQAKElp---lYCEFSPRSPLNF-------------KDIFPNASEMAIDLIQSLLRLNPLERISASQALEHEYFKsY 304
gi 219112487 225 TNWADFQTlplctrGLEWDETTAIPF-------------DEIFTAAPKDAISLLRSILVLDPNMRFTATQCLSHPYFSnD 291
                        330
                 ....*....|
Feature 1                  
1UA2_D       299 PGPTPGCQLP 308
gi 26392384  296 PKPTHPSLLP 305
gi 85099231  357 PKPTPKHDLP 366
gi 189205581 324 PRPTKKENLP 333
gi 125399    294 PPPSDPSSIK 303
gi 57230868  297 PPPTPPIALP 306
gi 50549857  297 PRPTKLAELP 306
gi 116507718 299 PYPTHPSKLP 308
gi 67594819  305 PLPCDPSELP 314
gi 219112487 292 PVPTLKEKLV 301

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