3BLH,3BLQ


Conserved Protein Domain Family
STKc_CDK9_like

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cd07840: STKc_CDK9_like (this model, PSSM-Id:143345 is obsolete and has been replaced by 270832)
Click on image for an interactive view with Cn3D
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 9 (CDK9)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing.
Statistics
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PSSM-Id: 143345
View PSSM: cd07840
Aligned: 36 rows
Threshold Bit Score: 387.671
Threshold Setting Gi: 19074929
Created: 29-Jul-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs with bound ATP or ATP analogs
  • Citation:PMID 8756328

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ####    #             # #                   #             #               
3BLH_A        20 YEKLAKIGQGTFGEVFKARHRkt-gQKVALKKVLMen---ekEGFPITALREIKILQLLkHENVVNLIEICRtkaspy-- 93
3BLQ_A        20 YEKLAKIGQGTFGEVFKARHRkt-gQKVALKKVLMen---ekEGFPITALREIKILQLLkHENVVNLIEICRtkaspy-- 93
gi 19074896   22 YEKIRIIGEGTFGQVILARKGr---ARYALKKVSKe-----kEGLSVTTIREVQVLRAMgHPSIVRLIEVVVep------ 87
gi 158563958  27 FRRIRKIGEGTYGEVFEAMDIit-gERAALKKIKLdd---gkEGFPRQILREIKLLKKLdHENIIRLKEIVVspgtahga 102
gi 74697003   26 YEVLGKLGEGTFGEVHRARSRkt-gALVALKKIIMhn---erDGFPITALREIKLLKLLsHKNVLRLEEMAIehpprt-- 99
gi 89290013   26 YRLIAEVGSGTYGRVYKAECLrt-kQYVALKKFESkddkikeDGFPITAVREILLLKQLdHVNIIKLREIILskpsek-- 102
gi 19074929   26 YEKVCRISSGSFGNVYRVRRKtd-nRVFALKRMNPsmc-ydtNGFSILYIREVMILKHIrHRNIMEIEEVVEgce----- 98
gi 223526953  26 YRRLDILGEGSYGQVFKAREIgt-gKTVAVKKLLItdh-eekEGFPITAIREIKILTNLhHDNVLGLKEIVTdykn---- 99
gi 124396484  14 YKVIAEVGSGTYGKVYKAKCLkt-nDFVALKKIDTkdqkimaEGFPITAIREIKLLKIMnHKNILRLREIIVskashr-- 90
gi 146175845  42 YEVLHEVGSGTYGRVYKANRKsvsnKLYALKQLDVsq---ekDGFPITALREIKLLQKLdQENVLKINEIVTmrtskd-- 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       ####  # ##                                          # # ## #     
3BLH_A        94 -----nrckgSIYLVFDFCEHDLAGLLsnvl------vkfTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITr-d 161
3BLQ_A        94 -----nrckgSIYLVFDFCEHDLAGLLsnvl------vkfTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITr-d 161
gi 19074896   88 --------ggDIYMVFPYFPYDLNRFIrsn--------kmTCSEIKHIFYQIAQGVCYIHSKGIMHRDLKSANILLDq-k 150
gi 158563958 103 ggsddymyrgDIYMVFEYMDHDLKKVLhh----------sTPSQVKYYMEQLLKGLHYCHVNNVLHRDIKGANLLISggg 172
gi 74697003  100 ----dkrtrpIVYMVTPYMDHDLSGLLdnps------vrfTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLINn-k 168
gi 89290013  103 -----ndyrgSTFLVFDYMDHDFAGLHrnk-------hefSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNn-q 169
gi 19074929   99 --------inDFFIVMECCDTDLRSVIhsv-------gkiGMKAARFLTCQMLKGLKFLHGAGIVHRDLKPSNILLMr-d 162
gi 223526953 100 -------ykgNTYLVFEYMEHDLASLShrynnnlkfatqfTATQIKCYMRQLLSGLSYCHANNVIHRDIKCANVLINh-e 171
gi 124396484  91 -----nnfrgSTFLVFDYYDHDFAGLHrqr-------nifTLPQLKCIFKQLLEGVKYLHDSKIIHRDLKCANILMNn-k 157
gi 146175845 117 ----kgkskiTTFLVFDYMEHDFQGLIrkk-------qpfTQPQIKCVMQQLFKGLDYLHNSNVIHRDLKSANLLLNk-d 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  #                      # #### #                                        
3BLH_A       162 GVLKLADFGLARAFSLAknsq-------pnrYXNRVVTLWYRPPELLLGer----------------------------- 205
3BLQ_A       162 GVLKLADFGLARAFSLAknsq-------pnrYXNRVVTLWYRPPELLLGer----------------------------- 205
gi 19074896  151 LNASIADFGMARYTTKTg------------aYTPGMVTLWYRAPEILLGss----------------------------- 189
gi 158563958 173 KLLKLADFGLARPFTRDg------------sFTNHVITLWYRPPELLLGat----------------------------- 211
gi 74697003  169 GVLQIADFGLARHYEGDipqpgkgsgegkrdYTSLVVTRWYRPPELLMHlk----------------------------- 219
gi 89290013  170 GEVKIADFGLARLLNPNnp-----------kYTNKVVTLWYRAPELLLGakeyteqhilkelirniksiqlsllisiylk 238
gi 19074929  163 GGLRIADFGLARAIESQ--------------MTNLVVTLWYRPIEILLGse----------------------------- 199
gi 223526953 172 GDLKIADFGLARWFVFKncdld----hlsprLTNKVVTLWYRPPELLLGat----------------------------- 218
gi 124396484 158 GQVTLADFGLARTLSNVsn----------pkYTYKVVTLWYRAPELLLGqt----------------------------- 198
gi 146175845 185 GVLKIGDFGLARQVERPll----------rpLTSVVVTLWYRAPEILLGdk----------------------------- 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           ##                                           
3BLH_A       206 ---------dYGPPIDLWGAGCIMAEMWTrSPIMQGNtEQHQLALISQLCGSITPEVWPnvdnyelyekLELVKGQKRKV 276
3BLQ_A       206 ---------dYGPPIDLWGAGCIMAEMWTrSPIMQGNtEQHQLALISQLCGSITPEVWPnvdnyelyekLELVKGQKRKV 276
gi 19074896  190 ---------sYTYAVDIWSLGCILTEMYLgHMIFQGStEMLQLEMVIHACGSINENSYPgvqdlpgfrnFRLPQSPRRIE 260
gi 158563958 212 ---------nYAEAVDIWSVGCIFAEFLLrKPLFPGRtEQEQLSKIFELCGFPNEENWPgvsklplyktIRPTTPTKRRL 282
gi 74697003  220 ---------rYTTAIDMWGVGCVFAEMLEgKPVLQGEsDLHQLELVWDLCGTPSEETMPgwrtlpggqaFSSKPRPGNLA 290
gi 89290013  239 ltvqssifkkSNKQIDMWSVGCIFIELAVgENLLRGEnEPRQLDKIYELCGSPNTQNWPevdklqlwkdMKPKRNFERKL 318
gi 19074929  200 ---------tYDESIDMWSVGCVVGEMLRgEPILAGEgEMDQLDRIFRLLGYPTDADFEgldlp-hfknIRRPSTFEASF 269
gi 223526953 219 ---------sYDTGVDMWSVGCVFAELLIgRAVLCGTsEADQLKKIIELCGAPDQDDWPgaselplydkFRPNGPARRRI 289
gi 124396484 199 ---------nYNTQIDMWSLGCIFTELITgDVLFKGDiEYRQMEKIYELCGSANEQNWPncvnlrqweeFKPRRNYERLL 269
gi 146175845 226 ---------nYSFKSDVWSAGCFMAELLLgEPIFNGKnESTQIEQIYEKCGSPDPDSWAglttfkfwkdLQPKKEYSASL 296
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
3BLH_A       277 K-DRLKayv------rdPYALDLIDKLLVLDPAQRIDSDDALNHDFF 316
3BLQ_A       277 K-DRLKayv------rdPYALDLIDKLLVLDPAQRIDSDDALNHDFF 316
gi 19074896  261 G-IIRKh---------dASAVELVSKMLCLDPSKRITVEQVVGSKYF 297
gi 158563958 283 R-DIFHnf--------dSHAVDLIDRMLILNPTERISAHDALCAAYF 320
gi 74697003  291 R-RFEKh---------gPVVISLLKELFKLDWRSRINAIDALNHPYF 327
gi 89290013  319 R-EQVIerkk----nidPQFLNLLDGIMVLNPKKRFTVQQCLDHEFF 360
gi 19074929  270 EgDFECy---------gEEAASFVRNLLSFDPRKRCTASQGLCSGFV 307
gi 223526953 290 R-DVFRga--------dRYAIGLLERMLMFDPSKRISARDALNAKYF 327
gi 124396484 270 T-KHIKelcqiqnkqidQVTLDLIEQLLILDPTKRLNAAQALNHEFF 315
gi 146175845 297 I-SYMKqkip----tidSSTLDFLQALLTMNPEERLDSNQALHHEYF 338

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