1QMZ,2FYS,1JNK,1JST,1PW2,1UA2


Conserved Protein Domain Family
STKc_CMGC

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cd05118: STKc_CMGC (this model, PSSM-Id:143333 is obsolete and has been replaced by 270688)
Click on image for an interactive view with Cn3D
Catalytic domain of CMGC family Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), CMGC family, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation.
Statistics
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Aligned: 10 rows
Threshold Bit Score: 440.226
Threshold Setting Gi: 157831562
Created: 5-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Structure:1QMZ_A; Human CDK2 binds MgATP and substrate p107 peptide; defined at 4A contacts.
    View structure with Cn3D
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####    #            # #                   #              #               
1QMZ_A      5 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdtete---gvpsTAIREISLLKELn-HPNIVKLLDVIHte------ 74  human
2FYS_A     29 YTNLSyIGEGAYGMVCSAYDNlnkVRVAIKKISPfehq----tycqRTLREIKILLRFr-HENIIGINDIIRapti-eqm 102 Norway rat
1JNK_A     64 YQNLKpIGSGAQGIVCAAYDAvldRNVAIKKLSRpfqnq---thakRAYRELVLMKCVn-HKNIISLLNVFTpqktleef 139 human
1JST_A      4 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdtete---gvpsTAIREISLLKELn-HPNIVKLLDVIHte------ 73  human
1PW2_A      4 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdtete---gvpsTAIREISLLKELn-HPNIVKLLDVIHte------ 73  human
1UA2_D     12 YEKLDfLGEGQFATVYKARDKntnQIVAIKKIKLghrseakdginrTALREIKLLQELs-HPNIIGLLDAFGhk------ 84  human
Q8IZL9      4 YCILGrIGEGAHGIVFKAKHVetgEIVALKKVALrrled---gfpnQALREIKALQEMedNQYVVQLKAVFPhg------ 74  human
P20794      4 YTTMRqLGDGTYGSVLMGKSNesgELVAIKRMKRkfys----wdecMNLREVKSLKKLn-HANVIKLKEVIRen------ 72  human
Q9UQ07      4 YKAIGkIGEGTFSEVMKMQSLrdgNYYACKQMKQrfes----ieqvNNLREIQALRRLnpHPNILMLHEVVFdrk----s 75  human
Q00532      4 YEKIGkIGEGSYGVVFKCRNRdtgQIVAIKKFLEseddp---vikkIALREIRMLKQLk-HPNLVNLLEVFRrk------ 73  human
Feature 1           ####  # ##                                     # # ## #          #  #     
1QMZ_A     75 nKLYLVFEFLHQDLKKFMdasaltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINteGAIKLADFGLARAFG 154 human
2FYS_A    103 kDVYIVQDLMETDLYKLLktq---hlSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNttCDLKICDFGLARVAD 179 Norway rat
1JNK_A    140 qDVYLVMELMDANLCQVIqm----elDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKsdCTLKILDFGLARTAG 215 human
1JST_A     74 nKLYLVFEFLHQDLKKFMdasaltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINteGAIKLADFGLARAFG 153 human
1PW2_A     74 nKLYLVFEFLHQDLKKFMdasaltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINteGAIKLADFGLARAFG 153 human
1UA2_D     85 sNISLVFDFMETDLEVIIkdns-lvlTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDenGVLKLADFGLAKSFG 163 human
Q8IZL9     75 gGFVLAFEFMLSDLAEVVrhaq-rplAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISasGQLKIADFGLARVFS 153 human
P20794     73 dHLYFIFEYMKENLYQLMkdrn-klfPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMgpELVKIADFGLARELR 151 human
Q9UQ07     76 gSLALICELMDMNIYELIrgrr-yplSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKq-DVLKLGDFGSCRSVY 153 human
Q00532     74 rRLHLVFEYCDHTVLHELdryq-rgvPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITkhSVIKLCDFGFARLLA 152 human
Feature 1              # #### #                                     #                         
1QMZ_A    155 Vpv---rtYXHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTrRALFPGdsEIDQLFRIFRTLGTPDEvvwpgv 231 human
2FYS_A    180 PdhdhtgfLTEYVATRWYRAPEIMLNskgYTKSIDIWSVGCILAEMLSnRPIFPGkhYLDQLNHILGILGSPSQedlnci 259 Norway rat
1JNK_A    216 Tsf----mMTPYVVTRYYRAPEVILGm-gYKENVDIWSVGCIMGEMVRhKILFPGrdYIDQWNKVIEQLGTPCPefmkkl 290 human
1JST_A    154 Vpv---rtYXHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTrRALFPGdsEIDQLFRIFRTLGTPDEvvwpgv 230 human
1PW2_A    154 Vpv---rtYTHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTrRALFPGdsEIDQLFRIFRTLGTPDEvvwpgv 230 human
1UA2_D    164 Spn---raYXHQVVTRWYRAPELLFGarmYGVGVDMWAVGCILAELLLrVPFLPGdsDLDQLTRIFETLGTPTEeqwpdm 240 human
Q8IZL9    154 Pdgs--rlYTHQVATRWYRAPELLYGarqYDQGVDLWSVGCIMGELLNgSPLFPGknDIEQLCYVLRILGTPNPqvwpel 231 human
P20794    152 Sqp----pYTDYVSTRWYRAPEVLLRssvYSSPIDVWAVGSIMAELYMlRPLFPGtsEVDEIFKICQVLGTPKKsdwpeg 227 human
Q9UQ07    154 Skq----pYTEYISTRWYRAPECLLTdgfYTYKMDLWSAGCVFYEIASlQPLFPGvnELDQISKIHDVIGTPAQkiltkf 229 human
Q00532    153 Gps---dyYTDYVATRWYRSPELLVGdtqYGPPVDVWAIGCVFAELLSgVPLWPGksDVDQLYLIRKTLGDLIPrhqqvf 229 human
Feature 1                                                                            
1QMZ_A    232 ts--mpdykpsfPKWARQDf-sKVVPpl------------dEDGRSLLSQMLHYDPNKRISaKAALAHPFF 287 human
2FYS_A    260 inlkarnyllslPHKNKVPw-nRLFPna------------dSKALDLLDKMLTFNPHKRIEvEQALAHPYL 317 Norway rat
1JNK_A    291 qpt-vrnyvenrPKYAGLTf-pKLFPdslfpadsehnklkaSQARDLLSKMLVIDPAKRISvDDALQHPYI 359 human
1JST_A    231 ts--mpdykpsfPKWARQDf-sKVVPpl------------dEDGRSLLSQMLHYDPNKRISaKAALAHPFF 286 human
1PW2_A    231 ts--mpdykpsfPKWARQDf-sKVVPpl------------dEDGRSLLSQMLHYDPNKRISaKAALAHPFF 286 human
1UA2_D    241 cs---lpdyvtfKSFPGIPl-hHIFSaa------------gDDLLDLIQGLFLFNPCARITaTQALKMKYF 295 human
Q8IZL9    232 tel-pdynkisfKEQVPMPl-eEVLPdv------------sPQALDLLGQFLLYPPHQRIAaSKALLHQYF 288 human
P20794    228 yql-assmnfrfPQCVPINl-kTLIPna------------sNEAIQLMTEMLNWDPKKRPTaSQALKHPYF 284 human
Q9UQ07    230 kq--sramnfdfPFKKGSGi-pLLTTnl------------sPQCLSLLHAMVAYDPDERIAaHQALQHPYF 285 human
Q00532    230 stn-qyfsgvkiPDPEDMEpleLKFPni------------sYPALGLLKGCLHMDPTQRLTcEQLLHHPYF 287 human

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