1QMZ,2FYS,1JNK,1JST,1PW2,1UA2


Conserved Protein Domain Family
STKc_CMGC

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cd05118: STKc_CMGC (this model, PSSM-Id:143333 is obsolete and has been replaced by 270688)
Click on image for an interactive view with Cn3D
Catalytic domain of CMGC family Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), CMGC family, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation.
Statistics
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PSSM-Id: 143333
View PSSM: cd05118
Aligned: 10 rows
Threshold Bit Score: 440.226
Threshold Setting Gi: 157831562
Created: 5-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
  • Structure:1QMZ_A; Human CDK2 binds MgATP and substrate p107 peptide; defined at 4A contacts.
    View structure with Cn3D
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ####    #            # #                   #              #               
1QMZ_A         5 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdtete---gvpsTAIREISLLKELn-HPNIVKLLDVIHte------ 74
2FYS_A        29 YTNLSyIGEGAYGMVCSAYDNlnkVRVAIKKISPfehq----tycqRTLREIKILLRFr-HENIIGINDIIRapti-eqm 102
1JNK_A        64 YQNLKpIGSGAQGIVCAAYDAvldRNVAIKKLSRpfqnq---thakRAYRELVLMKCVn-HKNIISLLNVFTpqktleef 139
1JST_A         4 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdtete---gvpsTAIREISLLKELn-HPNIVKLLDVIHte------ 73
1PW2_A         4 FQKVEkIGEGTYGVVYKARNKltgEVVALKKIRLdtete---gvpsTAIREISLLKELn-HPNIVKLLDVIHte------ 73
1UA2_D        12 YEKLDfLGEGQFATVYKARDKntnQIVAIKKIKLghrseakdginrTALREIKLLQELs-HPNIIGLLDAFGhk------ 84
gi 74759739    4 YCILGrIGEGAHGIVFKAKHVetgEIVALKKVALrrled---gfpnQALREIKALQEMedNQYVVQLKAVFPhg------ 74
gi 13432166    4 YTTMRqLGDGTYGSVLMGKSNesgELVAIKRMKRkfys----wdecMNLREVKSLKKLn-HANVIKLKEVIRen------ 72
gi 41017258    4 YKAIGkIGEGTFSEVMKMQSLrdgNYYACKQMKQrfes----ieqvNNLREIQALRRLnpHPNILMLHEVVFdrk----s 75
gi 229463050   4 YEKIGkIGEGSYGVVFKCRNRdtgQIVAIKKFLEseddp---vikkIALREIRMLKQLk-HPNLVNLLEVFRrk------ 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ####  # ##                                     # # ## #          #  #     
1QMZ_A        75 nKLYLVFEFLHQDLKKFMdasaltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINteGAIKLADFGLARAFG 154
2FYS_A       103 kDVYIVQDLMETDLYKLLktq---hlSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNttCDLKICDFGLARVAD 179
1JNK_A       140 qDVYLVMELMDANLCQVIqm----elDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKsdCTLKILDFGLARTAG 215
1JST_A        74 nKLYLVFEFLHQDLKKFMdasaltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINteGAIKLADFGLARAFG 153
1PW2_A        74 nKLYLVFEFLHQDLKKFMdasaltgiPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINteGAIKLADFGLARAFG 153
1UA2_D        85 sNISLVFDFMETDLEVIIkdns-lvlTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDenGVLKLADFGLAKSFG 163
gi 74759739   75 gGFVLAFEFMLSDLAEVVrhaq-rplAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISasGQLKIADFGLARVFS 153
gi 13432166   73 dHLYFIFEYMKENLYQLMkdrn-klfPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMgpELVKIADFGLARELR 151
gi 41017258   76 gSLALICELMDMNIYELIrgrr-yplSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKq-DVLKLGDFGSCRSVY 153
gi 229463050  74 rRLHLVFEYCDHTVLHELdryq-rgvPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITkhSVIKLCDFGFARLLA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # #### #                                     #                         
1QMZ_A       155 Vpv---rtYXHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTrRALFPGdsEIDQLFRIFRTLGTPDEvvwpgv 231
2FYS_A       180 PdhdhtgfLTEYVATRWYRAPEIMLNskgYTKSIDIWSVGCILAEMLSnRPIFPGkhYLDQLNHILGILGSPSQedlnci 259
1JNK_A       216 Tsf----mMTPYVVTRYYRAPEVILGm-gYKENVDIWSVGCIMGEMVRhKILFPGrdYIDQWNKVIEQLGTPCPefmkkl 290
1JST_A       154 Vpv---rtYXHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTrRALFPGdsEIDQLFRIFRTLGTPDEvvwpgv 230
1PW2_A       154 Vpv---rtYTHEVVTLWYRAPEILLGckyYSTAVDIWSLGCIFAEMVTrRALFPGdsEIDQLFRIFRTLGTPDEvvwpgv 230
1UA2_D       164 Spn---raYXHQVVTRWYRAPELLFGarmYGVGVDMWAVGCILAELLLrVPFLPGdsDLDQLTRIFETLGTPTEeqwpdm 240
gi 74759739  154 Pdgs--rlYTHQVATRWYRAPELLYGarqYDQGVDLWSVGCIMGELLNgSPLFPGknDIEQLCYVLRILGTPNPqvwpel 231
gi 13432166  152 Sqp----pYTDYVSTRWYRAPEVLLRssvYSSPIDVWAVGSIMAELYMlRPLFPGtsEVDEIFKICQVLGTPKKsdwpeg 227
gi 41017258  154 Skq----pYTEYISTRWYRAPECLLTdgfYTYKMDLWSAGCVFYEIASlQPLFPGvnELDQISKIHDVIGTPAQkiltkf 229
gi 229463050 153 Gps---dyYTDYVATRWYRSPELLVGdtqYGPPVDVWAIGCVFAELLSgVPLWPGksDVDQLYLIRKTLGDLIPrhqqvf 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                               
1QMZ_A       232 ts--mpdykpsfPKWARQDf-sKVVPpl------------dEDGRSLLSQMLHYDPNKRISaKAALAHPFF 287
2FYS_A       260 inlkarnyllslPHKNKVPw-nRLFPna------------dSKALDLLDKMLTFNPHKRIEvEQALAHPYL 317
1JNK_A       291 qpt-vrnyvenrPKYAGLTf-pKLFPdslfpadsehnklkaSQARDLLSKMLVIDPAKRISvDDALQHPYI 359
1JST_A       231 ts--mpdykpsfPKWARQDf-sKVVPpl------------dEDGRSLLSQMLHYDPNKRISaKAALAHPFF 286
1PW2_A       231 ts--mpdykpsfPKWARQDf-sKVVPpl------------dEDGRSLLSQMLHYDPNKRISaKAALAHPFF 286
1UA2_D       241 cs---lpdyvtfKSFPGIPl-hHIFSaa------------gDDLLDLIQGLFLFNPCARITaTQALKMKYF 295
gi 74759739  232 tel-pdynkisfKEQVPMPl-eEVLPdv------------sPQALDLLGQFLLYPPHQRIAaSKALLHQYF 288
gi 13432166  228 yql-assmnfrfPQCVPINl-kTLIPna------------sNEAIQLMTEMLNWDPKKRPTaSQALKHPYF 284
gi 41017258  230 kq--sramnfdfPFKKGSGi-pLLTTnl------------sPQCLSLLHAMVAYDPDERIAaHQALQHPYF 285
gi 229463050 230 stn-qyfsgvkiPDPEDMEpleLKFPni------------sYPALGLLKGCLHMDPTQRLTcEQLLHHPYF 287

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