cd05118: STKc_CMGC (this model, PSSM-Id:143333 is obsolete and has been replaced by 270688)
Catalytic domain of CMGC family Serine/Threonine Kinases
Serine/Threonine Kinases (STKs), CMGC family, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation.
Comment:based on the structure of human CDK2 bound with ATP and substrate peptide, and on the structures of other CDKs or MAPKs, bound with ATP or ATP analogs
Structure:1QMZ_A; Human CDK2 binds MgATP and substrate p107 peptide; defined at 4A contacts. - View structure with Cn3D
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",