Conserved Protein Domain Family
Ig_Aggrecan_like

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cd05878: Ig_Aggrecan_like (this model, PSSM-Id:143286 is obsolete and has been replaced by 319319)
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG)
Ig_Aggrecan_like: immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG)s. Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.
Statistics
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PSSM-Id: 143286
View PSSM: cd05878
Aligned: 10 rows
Threshold Bit Score: 176.791
Threshold Setting Gi: 160332364
Created: 11-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111306117   50 LAQSVALPCLFllhpshppqqpndtsesPRIKWSrlq----pgiGQKE-VPVLVArdnvvkvargyegrvSLPGYPHNRY 124
gi 129886      43 LGTSLTIPCYFidpmhpvttapstaplaPRIKWSrv-------sKEKE-VVLLVAtegrvrvnsayqdkvSLPNYPAIPS 114
gi 2506814     43 LGSSLNIPCYFnipeeed----tnalltPRIKWSkl-------sNGTE-IVLLVAtggkirlnaeyreviSLPNYPAIPT 110
gi 47550825    41 LAQSVVLPCRFlvlpplpgssvithsdhLRIKWTkl-------qSHGE-AVAVVAqngivkmgqeymgrvSVPSRPEDQG 112
gi 2506816     36 LSGKVSLPCHFstmptlpp--syntsefLRIKWSkievd-kngkDLKE-TTVLVAqngnikigqdykgrvSVPTHPEAVG 111
gi 47214702    21 LGSKVLVPCYFqdniakdpgaptvaplsHHIKWTfi-------tKEKI-SRILVAsegkvhveteyldrvTMINYPLVSS 92
gi 94733064    13 LSGSALLPCVFtlsps-------pshepPRIKWTklwgqrgpdgLQKQ-QSILVAkdniikvkkafqgrvTLPGYPGNRY 84
gi 158138921   36 LSGRVNLPCFFstiptlpp-synitnefLRIKWTkivqs-rdgkDPKE-TTVLVAqsgsikigqhyrgrvSVPSHPEDIG 112
gi 160332364   51 LAELVALPCLFtlqprp-----saardaPRIKWTkvr----tasGQRQdLPILVAkdnvvrvakswqgrvSLPSYPRRRA 121
gi 189520501  137 LSSSVLLPCVFtlpaaa-----sspphgPFIHWThg-------sGAQQ-RTVVSArdgvlrvhqafagrlRLPGYSKNQL 203
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 111306117  125 NATLVLssARVSDSGVYRCEVIYGIDDEQDTVPLEVTGLV 164
gi 129886     115 DATLEVqsLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIV 154
gi 2506814    111 DATLEIkaLRSNHTGIYRCEVMYGIEDRQDTIEVLVKGVV 150
gi 47550825   113 DASLTIsrLRASDAGVYRCEVMHGIEDTQDSITLDVSGVV 152
gi 2506816    112 DASLTVvkLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVV 151
gi 47214702    93 DASIEIteLRSKDSGTYRCEVIHGIEDNYDSVTIQVQGIV 132
gi 94733064    85 NASLVLtgLRSSDSGMYRCEVVVGINDEQDTVPLQVTGVV 124
gi 158138921  113 DASLTIvkLRASDAGAYRCEVLFGIEDTQDTVSLDVSGVV 152
gi 160332364  122 NATLLLgpLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVV 161
gi 189520501  204 NASLELsrLRYNDSGTFRCHVALGENYEQDTVHLEVTGVV 243
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