Conserved Protein Domain Family
Ig3_L1-CAM

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cd05876: Ig3_L1-CAM 
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
Ig3_L1-CAM: third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains, five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM.
Statistics
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PSSM-Id: 143284
View PSSM: cd05876
Aligned: 3 rows
Threshold Bit Score: 128.505
Threshold Setting Gi: 1171701
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1171701    256 VVLECIAEGLPTPWVRWRRLNGpllp--ggvgNFNKTLRLWGVtESDDGEYECVAENGRGTaRGTHSVTVE 324
gi 134085228  265 LTLECIPEGLPTPEVHWDRIDSalspnrtkklYNNRWLQIDNVlESDDGEYVCTARNSENSvKHHYTVTVE 335
gi 1705571    260 LVLECIAEGFPTPTIKWLRPSGpmpadrvtyqNHNKTLQLLKVgEEDDGEYRCLAENSLGSaRHAYYVTVE 330
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