1OLZ


Conserved Protein Domain Family
Ig_Sema4D_like

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cd05873: Ig_Sema4D_like 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of Sema4D. Sema4D is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4D has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4D plays a part in the development of GABAergic synapses. Sema4D in addition is an immune semaphorin. It is abundant on resting T cells; its expression is weak on resting B cells and antigen presenting cells (APCs), but is upregulated by various stimuli. The receptor used by Sema4D in the immune system is CD72. Sem4D enhances the activation of B cells and DCs through binding CD72, perhaps by reducing CD72s inhibitory signals. The receptor used by Sema4D in the non-lymphatic tissues is plexin-B1. Sem4D is anchored to the cell surface but its extracellular domain can be released from the cell surface by a metalloprotease-dependent process. Sem4D may mediate its effects in its membrane bound form, and/or its cleaved form.
Statistics
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PSSM-Id: 143281
View PSSM: cd05873
Aligned: 5 rows
Threshold Bit Score: 146.503
Threshold Setting Gi: 47228359
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1OLZ_A, human semophorin SEMA4D fragment, dimer interface defined by 3.5A distance.
    View structure with Cn3D
  • Comment:Dimer interface involves both the Sema domain and the C-terminal Ig domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                        #                          
1OLZ_A        538 GSYRQHFFKHGGTAELKCSqksnLARVFWKFQngvlkaespkyglmgrKNLLIFNLsegDSGVYQCLSEERVKnkTVFQV 617
gi 118103273  344 NDVRKYLFTLGNNVHLKCVplsnLARVVWKFNgsriqdkd-skyllydGGIAIFNVtvaETGFYDCLSVEKSKakEFFIT 422
gi 118104200  545 ENSLQHTFKHGSTAELKCSqksnLAQVVWKFRddvlrves-pkyrlleKALLIFNLsegDSGVYQCLSEEKVKnkKFSQV 623
gi 47228359   473 LDPLERTIWPGGNLNLSCSlpsqLAKTVWELDgktltpt--arvqslrDGLLIFHAsgsDAGRYRCLSVEKSKagLFTTT 550
gi 121583871  542 IEPKVRTLVLGNNIRLLCRpdsnLAQVNWNLAgkplpfsn-rkytiynDAILISNAssaDAGRYTCVSVEQAKgkHYTKT 620

                  ....*...
Feature 1                 
1OLZ_A        618 VAKHVLEV 625
gi 118103273  423 VARYALYA 430
gi 118104200  624 LAKHVLEL 631
gi 47228359   551 VAEYQLVG 558
gi 121583871  621 LAIYDLHE 628

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