Conserved Protein Domain Family
Ig3_L1-CAM_like

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cd05731: Ig3_L1-CAM_like (this model, PSSM-Id:143208 is obsolete and has been replaced by 409394)
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
Ig3_L1-CAM_like: domain similar to the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.
Statistics
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PSSM-Id: 143208
Aligned: 10 rows
Threshold Bit Score: 130.952
Threshold Setting Gi: 1171701
Created: 11-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAI35443      262 LQLECIAEGLPTPEIEWIPLLGstyneriqfdDFKKTLHIDKVqDEDDGDYQCIAKNTQGSsSHTFTVVVE 332  western clawed frog
1171701       256 VVLECIAEGLPTPWVRWRRLNGpllp--ggvgNFNKTLRLWGVtESDDGEYECVAENGRGTaRGTHSVTVE 324  chicken
1705571       260 LVLECIAEGFPTPTIKWLRPSGpmpadrvtyqNHNKTLQLLKVgEEDDGEYRCLAENSLGSaRHAYYVTVE 330  human
XP_414434     275 LQLECIAEGLPTPHLSWVKVTGslpkdkpvtdKFGKVLKIENVsAADEGTYQCTASNPVGRaKHEFHVHVE 345  chicken
CAM60094      265 LTLECIPEGLPTPEVHWDRIDSalspnrtkklYNNRWLQIDNVlESDDGEYVCTARNSENSvKHHYTVTVE 335  zebrafish
NP_001038270  282 LELECIADGLPTPNISWTKVNGelpsgrfsfySFQKTLKIKEVtEADGGDYRCIAKNRMGSsQHTITVVVR 352  zebrafish
O94856        264 LLLECIASGVPTPDIAWYKKGGdlpsdkakfeNFNKALRITNVsEEDSGEYFCLASNKMGSiRHTISVRVK 334  human
P35331        264 LLLECIAAGLPTPVIRWIKEGGelpanrtffeNFKKTLKIIDVsEADSGNYKCTARNTLGStHHVISVTVK 334  chicken
O00533        258 LLLECFAEGLPTPQVDWNKIGGdlpkgretkeNYGKTLKIENVsYQDKGNYRCTASNFLGTaTHDFHVIVE 328  human
NP_001004709  265 LLLECIASGVPAPDIMWYKKGGelpagktkleNFNKALRISNVsEEDSGEYFCLASNKMGSiRHTISVRVK 335  chicken
1171701       256 VVLECIAEGLPTPWVRWRRLNGpllp--ggvgNFNKTLRLWGVtESDDGEYECVAENGRGTaRGTHSVTVE 324  chicken
1705571       260 LVLECIAEGFPTPTIKWLRPSGpmpadrvtyqNHNKTLQLLKVgEEDDGEYRCLAENSLGSaRHAYYVTVE 330  human
XP_414434     275 LQLECIAEGLPTPHLSWVKVTGslpkdkpvtdKFGKVLKIENVsAADEGTYQCTASNPVGRaKHEFHVHVE 345  chicken
CAM60094      265 LTLECIPEGLPTPEVHWDRIDSalspnrtkklYNNRWLQIDNVlESDDGEYVCTARNSENSvKHHYTVTVE 335  zebrafish
NP_001038270  282 LELECIADGLPTPNISWTKVNGelpsgrfsfySFQKTLKIKEVtEADGGDYRCIAKNRMGSsQHTITVVVR 352  zebrafish
O94856        264 LLLECIASGVPTPDIAWYKKGGdlpsdkakfeNFNKALRITNVsEEDSGEYFCLASNKMGSiRHTISVRVK 334  human
P35331        264 LLLECIAAGLPTPVIRWIKEGGelpanrtffeNFKKTLKIIDVsEADSGNYKCTARNTLGStHHVISVTVK 334  chicken
O00533        258 LLLECFAEGLPTPQVDWNKIGGdlpkgretkeNYGKTLKIENVsYQDKGNYRCTASNFLGTaTHDFHVIVE 328  human
NP_001004709  265 LLLECIASGVPAPDIMWYKKGGelpagktkleNFNKALRISNVsEEDSGEYFCLASNKMGSiRHTISVRVK 335  chicken
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