Conserved Protein Domain Family
Ig_CSPGs_LP

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cd05714: Ig_CSPGs_LP (this model, PSSM-Id:143191 is obsolete and has been replaced by 319292)
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP) and similar proteins
Ig_CSPGs_LP: immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.
Statistics
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PSSM-Id: 143191
View PSSM: cd05714
Aligned: 22 rows
Threshold Bit Score: 135.069
Threshold Setting Gi: 47214540
Created: 4-Sep-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111306117  50 LAQSVALPCLFllhpshppqqpndtsesPRIKWSrlqpgiGQKEVPVLVArdnvvkvargyegrvSLPGYPHNRYNATLV 129
gi 50417764   97 RGGNATLPCTFhyepkl------nstrkYRVKWSklh-kdNTKERDVLVAiglrhrs--fgeykgRVHLIQKMPNEVSLV 167
gi 47085841   64 QGSNVTLPCHYryepal------saprrTRVKWFwqpvngEGQEHDVMVAigtrhrs--ygdfkgRVRLRRSTPGDASLV 135
gi 113678501  24 RGGTITLPCRYhheped------idpnrIRIKWTkv--sdAFQFEDVFVAlgrqqka--fgsyqeRVSLEQAGPGDASVI 93
gi 148745617  33 RGDNITLPCRLdgqs---------tlfgNRIKWTki--edDSTETDVLISmgfhkka--ygsyqdRAYLLEVDDSDATLV 99
gi 134085246  47 RGHAAILPCVMrfk-----------pshYRVKWTklepssRGVENIVLITnghadkq--ygsvgpRAALQRAHDLDVSLR 113
gi 47226733  591 PGGNATLPCRLlskr---------hnpgVQVRWTkle-ndEAPLEDVLLWlgtrskt--fgrfenRVFLQAADDRDASLV 658
gi 47228555   20 RGGNATLPCKIqrdqsl------apnrkMRIKWTklt-sdYLKEVDVFVAmdyhkrs--ygsfhgRVHLQGSSPMDASLV 90
gi 47605665   62 QGASVTLPCHYhyepal------asprhVRVKWWkls-enGAPEQDVLVVigqrhrs--fgdyqgRVQLRQDKQQEVSLE 132
gi 118095905  63 SGVNVTLPCHYhhepes------eakhkIRIKWSklr-ddYTKEQDVLVAigktyma--fgdfqgRAHLHRAGQREASLL 133
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 111306117 130 LssARVSDSGVYRCEVIYGIDDEQDTVPLEVTGLV 164
gi 50417764  168 ItdLRLEDYGNYKCEVIDGLEDESGIVELELRGVV 202
gi 47085841  136 InpLQSDDTGRYRCEIIDGLEDESVTMQLKFRGVV 170
gi 113678501  94 IhnITLEDYGRYECEVTNDMEDDTGFVNLDLEGVV 128
gi 148745617 100 ItdLDVNDYGTYRCEFIDGMNDMTLEVDLEVQGVV 134
gi 134085246 114 LsdLELEDDGSYRCELINGIEDESVIITLRIEGVV 148
gi 47226733  659 ItdIATEDIGQYRCEVSDGMKHTAEEGFLKVQGCV 693
gi 47228555   91 IteITLEDYGRYKCEVIDGLEDGTAVVTLDLEGIV 125
gi 47605665  133 LrdLRLEDSGRYRCEVIDGLEDESGLVELELRGVV 167
gi 118095905 134 IsdVRLQDDGKYRCEVIDGLEDASDVVELRLRGGG 168
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