1NFD,1MI5,2NW2,2P5E,2Z35,2IAL,1BD2,1D9K,2EYR,1AO7,1OGA,1FYT,1YMM,2ESV,1YPZ,2AK4,1TVD,2F53


Conserved Protein Domain Family
IgV_TCR_alpha_like
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cd04983: IgV_TCR_alpha_like (this model, PSSM-Id:143184 is obsolete and has been replaced by 409372)
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Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins
IgV_TCR_alpha: immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens; they recognize proteins antigens directly and without antigen processing, and MHC independently of the bound peptide.
Links
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Statistics
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PSSM-Id: 143184
Aligned: 32 rows
Threshold Bit Score: -1
Created: 21-Sep-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:IgV heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD_A; human alpha/beta T-cell receptor (TCR) alpha chain IgV domain forms interface with beta chain IgV domain, contacts based on 3.5 A distance.
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  • Comment:Human alpha/beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      # #    #  #  #                                 
1NFD_A      3 VTQteglVTVTEGLPVKLNCTYQttylTIAFFWYVQYLneAPQVLLKSstdnkrtehqgFHATLHks-sSSFHLQKSSaq 81  Mus musculus
2IAL_A      3 VEQsppdLILQEGANSTLRCNFSd--sVNNLQWFHQNPwgQLINLFYIpsgtk--qngrLSATTVat-eRYSLLYISSsq 77  human
1BD2_D      3 VKQnspsLSVQEGRISILNCDYTns-mFDYFLWYKKYPaeGPTFLISIssikdknadgrFTVFLNks-aKHLSLHIVPsq 80  Homo sapiens
1D9K_A      2 VRQspqsLTVWEGETTILNCSYEds-tFDYFPWYRQFPgkSPALLIAIslvsnkkedgrFTIFFNkr-eKKLSLHITDsq 79  house mouse
2EYR_A      6 VEQspqsLIILEGKNCTLQCNYTvs-pFSNLRWYKQDTgrGPVSLTIMtfsentksngrYTATLDad-tKQSSLHITAsq 83  human
1OGA_D      4 LEQspqfLSIQEGENLTVYCNSSs--vFSSLQWYRQEPgeGPVLLVTVvtggevkklkrLTFQFGda-rKDSSLHITAaq 80  human
1YMM_D      5 EEDpq-aLSIQEGENATMNCSYKt--sINNLQWYRQNSgrGLVHLILIrsnerekhsgrLRVTLDts-kKSSSLLITAsr 80  human
1YPZ_E      4 VEQspsaLSLHEGTDSALRCNFTt--tMRSVQWFRQNSrgSLISLFYLasgtk--engrLKSAFDskerRYSTLHIRDaq 79  house mouse
2F53_D      5 VTQipaaLSVPEGENLVLNCSFTds-aIYNLQWFRQDPgkGLTSLLLIpfwqreqtsgrLNASLDks-sGRSTLYIAAsq 82  human
AAA60641   25 VEQgpqsLHVQEGDSTNFTCSFPss-nFYALHWYRWETakTPEALFVMtlngdekkkgrISATLNtk-eGYSYLYIKGsq 102 human
2IAL_A      3 VEQsppdLILQEGANSTLRCNFSd--sVNNLQWFHQNPwgQLINLFYIpsgtk--qngrLSATTVat-eRYSLLYISSsq 77  human
1BD2_D      3 VKQnspsLSVQEGRISILNCDYTns-mFDYFLWYKKYPaeGPTFLISIssikdknadgrFTVFLNks-aKHLSLHIVPsq 80  Homo sapiens
1D9K_A      2 VRQspqsLTVWEGETTILNCSYEds-tFDYFPWYRQFPgkSPALLIAIslvsnkkedgrFTIFFNkr-eKKLSLHITDsq 79  house mouse
2EYR_A      6 VEQspqsLIILEGKNCTLQCNYTvs-pFSNLRWYKQDTgrGPVSLTIMtfsentksngrYTATLDad-tKQSSLHITAsq 83  human
1OGA_D      4 LEQspqfLSIQEGENLTVYCNSSs--vFSSLQWYRQEPgeGPVLLVTVvtggevkklkrLTFQFGda-rKDSSLHITAaq 80  human
1YMM_D      5 EEDpq-aLSIQEGENATMNCSYKt--sINNLQWYRQNSgrGLVHLILIrsnerekhsgrLRVTLDts-kKSSSLLITAsr 80  human
1YPZ_E      4 VEQspsaLSLHEGTDSALRCNFTt--tMRSVQWFRQNSrgSLISLFYLasgtk--engrLKSAFDskerRYSTLHIRDaq 79  house mouse
2F53_D      5 VTQipaaLSVPEGENLVLNCSFTds-aIYNLQWFRQDPgkGLTSLLLIpfwqreqtsgrLNASLDks-sGRSTLYIAAsq 82  human
AAA60641   25 VEQgpqsLHVQEGDSTNFTCSFPss-nFYALHWYRWETakTPEALFVMtlngdekkkgrISATLNtk-eGYSYLYIKGsq 102 human

Feature 1          # #                #   # #       
1NFD_A     82 lSDSALYYCALSEGg--------nYKYVFGAGTRLKVI 111 Mus musculus
2IAL_A     78 tTDSGVYFCAALIQg--------aQKLVFGQGTRLTIN 107 human
1BD2_D     81 pGDSAVYFCAAMEGa---------QKLVFGQGTRLTIN 109 Homo sapiens
1D9K_A     80 pGDSATYFCAATGSf---------NKLTFGAGTRLAVS 108 house mouse
2EYR_A     84 lSDSASYICVVSDRgs------tlGRLYFGRGTQLTVW 115 human
1OGA_D     81 pGDTGLYLCAGAGSq---------GNLIFGKGTKLSVK 109 human
1YMM_D     81 aADTASYFCATDTTsg-------tYKYIFGTGTRLKVL 111 human
1YPZ_E     80 lEDSGTYFCAADTWhisegyelgtDKLVFGQGTQVTVE 117 house mouse
2F53_D     83 pGDSATYLCAVRPTsg------gsYIPTFGRGTSLIVH 114 human
AAA60641  103 pEDSATYLCAFISDagg----tsyGKLTFGQGTILTVH 136 human
2IAL_A     78 tTDSGVYFCAALIQg--------aQKLVFGQGTRLTIN 107 human
1BD2_D     81 pGDSAVYFCAAMEGa---------QKLVFGQGTRLTIN 109 Homo sapiens
1D9K_A     80 pGDSATYFCAATGSf---------NKLTFGAGTRLAVS 108 house mouse
2EYR_A     84 lSDSASYICVVSDRgs------tlGRLYFGRGTQLTVW 115 human
1OGA_D     81 pGDTGLYLCAGAGSq---------GNLIFGKGTKLSVK 109 human
1YMM_D     81 aADTASYFCATDTTsg-------tYKYIFGTGTRLKVL 111 human
1YPZ_E     80 lEDSGTYFCAADTWhisegyelgtDKLVFGQGTQVTVE 117 house mouse
2F53_D     83 pGDSATYLCAVRPTsg------gsYIPTFGRGTSLIVH 114 human
AAA60641  103 pEDSATYLCAFISDagg----tsyGKLTFGQGTILTVH 136 human

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