1FYT,1HXM,1HXM,2COQ,1NFD,1RHH,2ADG,2ATP,2OTU,1NFD,2UV3,1NFD,1NPU,1SQ2,1VES,1KB5,1RHH,2AK4,1QLR,2C1O,1IQD,1YPZ,1MI5,2NW2,2P5E,2Z35,2IAL,1BD2,1D9K,2EYR,1AO7,1OGA,1YMM,2ESV,1YPZ,1TVD,1KTK,2EYR,1ZGL,1OGA,1BWM,1J8H,2ESV,1MI5,1LIL,1DL7,1CD0,1AQK,1ZV5,2IG2,2ZJS,1DQT,1I8L,1AH1


Conserved Protein Domain Family
IgV
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cd00099: IgV (this model, PSSM-Id:143167 is obsolete and has been replaced by 409355)
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Immunoglobulin variable domain (IgV)
IgV: Immunoglobulin variable domain (IgV). Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Links
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Statistics
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PSSM-Id: 143167
Aligned: 116 rows
Threshold Bit Score: -1
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD_A, human T cell receptor alpha/beta interface, contacts based on 3.5 A distance.
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  • Structure:1RHH_B; human monoclonal antibody Fab X5 heterodimer, showing light and heavy chain interface, contacts based on 3.5 A distance.
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  • Structure:2ADG_A, mouse monoclonal anti-Cd4 antibody Q425, Fab light and heavy chain interface, contacts based on 3.5 A
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  • Structure:1HXM_B, human T cell receptor gamma/delta interface, contacts based on 3.5 A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             # # # #         # #                                     
1FYT_D     10 VSVSEGALVLLRCNYsss---vpPYLFWYVQypn----qgLQLLlkytsaat-----lvkgingFEAEFKksetSFHLTK 77  human
1NFD_A     10 VTVTEGLPVKLNCTYqtt--yltIAFFWYVQyln----eaPQVLlksstdn------krtehqgFHATLHksssSFHLQK 77  Mus musculus
2ATP_B      8 LLVQTNHTAKMSCEVksi--sklTSIYWLRErqdp-kdkyFEFLaswssskgvlygesvdkkrnIILESSds-rRPFLSI 83  house mouse
1NPU_A      9 LTVSEGANATFTCSLsnw--sedLMLNWNRLsps----nqTEKQaafsngls-----qpvqdarFQIIQLpnrhDFHMNI 77  house mouse
1DQT_A      9 VLASSHGVASFPCEYspshntdeVRVTVLRQtn-----dqMTEVcattftekn--tvgfldypfCSGTFNe--sRVNLTI 79  house mouse
P10966     29 IKVQTNKMVMLSCEAkis--lsnMRIYWLRQrqapssdshHEFLalwdsakgt--ihgeeveqeKIAVFRda-sRFILNL 103 human
CAA81258   30 ILTKTNNSTEIVCPMkg----ehTGVYWYRWnqg---rqhFEFLlfssplgkatygtnisqekfSIRGTSsy-hSYRLHI 101 chicken
NP_998927  29 VMAQTNQTVKLSCEArtf--ptnTRIYWLRLrqalsanshYEFLalwipngnp---vygketekQLTVLQds-sRYLLQL 102 pig
1I8L_C     11 VLASSRGIASFVCEYaspgkateVRVTVLRQad-----sqVTEVcaatymmgn--eltflddsiCTGTSSg--nQVNLTI 81  human
1AH1_A     10 VLASSRGIASFVCEYaspgkateVRVTVLRQad-----sqVTEVcaatymmgn--eltflddsiCTGTSSg--nQVNLTI 80  human
1NFD_A     10 VTVTEGLPVKLNCTYqtt--yltIAFFWYVQyln----eaPQVLlksstdn------krtehqgFHATLHksssSFHLQK 77  Mus musculus
2ATP_B      8 LLVQTNHTAKMSCEVksi--sklTSIYWLRErqdp-kdkyFEFLaswssskgvlygesvdkkrnIILESSds-rRPFLSI 83  house mouse
1NPU_A      9 LTVSEGANATFTCSLsnw--sedLMLNWNRLsps----nqTEKQaafsngls-----qpvqdarFQIIQLpnrhDFHMNI 77  house mouse
1DQT_A      9 VLASSHGVASFPCEYspshntdeVRVTVLRQtn-----dqMTEVcattftekn--tvgfldypfCSGTFNe--sRVNLTI 79  house mouse
P10966     29 IKVQTNKMVMLSCEAkis--lsnMRIYWLRQrqapssdshHEFLalwdsakgt--ihgeeveqeKIAVFRda-sRFILNL 103 human
CAA81258   30 ILTKTNNSTEIVCPMkg----ehTGVYWYRWnqg---rqhFEFLlfssplgkatygtnisqekfSIRGTSsy-hSYRLHI 101 chicken
NP_998927  29 VMAQTNQTVKLSCEArtf--ptnTRIYWLRLrqalsanshYEFLalwipngnp---vygketekQLTVLQds-sRYLLQL 102 pig
1I8L_C     11 VLASSRGIASFVCEYaspgkateVRVTVLRQad-----sqVTEVcaatymmgn--eltflddsiCTGTSSg--nQVNLTI 81  human
1AH1_A     10 VLASSRGIASFVCEYaspgkateVRVTVLRQad-----sqVTEVcaatymmgn--eltflddsiCTGTSSg--nQVNLTI 80  human

Feature 1              # # #            ###      
1FYT_D     78 PsahmsdaAEYFCAVSespfgneklTFGTGTRLTI 112 human
1NFD_A     78 SsaqlsdsALYYCALSeggn--ykyVFGAGTRLKV 110 Mus musculus
2ATP_B     84 MnvkpedsDFYFCATVgsp----kmVFGTGTKLTV 114 house mouse
1NPU_A     78 LdtrrndsGIYLCGAIslhp-kakiEESPGAELVV 111 house mouse
1DQT_A     80 QglravdtGLYLCKVElmypppyfvGMGNGTQIYV 114 house mouse
P10966    104 TsvkpedsGIYFCMIVgsp----elTFGKGTQLSV 134 human
CAA81258  102 NrlhgsdnGTYYCCTIqss----qlILGTGTQLDV 132 chicken
NP_998927 103 RhvkpadsGNYFCMAVgnp----elTFGKGTRLSV 133 pig
1I8L_C     82 QglramdtGLYICKVElmypppyylGIGNGAQIYV 116 human
1AH1_A     81 QglramdtGLYICKVElmypppyylGIGNGTQIYV 115 human
1NFD_A     78 SsaqlsdsALYYCALSeggn--ykyVFGAGTRLKV 110 Mus musculus
2ATP_B     84 MnvkpedsDFYFCATVgsp----kmVFGTGTKLTV 114 house mouse
1NPU_A     78 LdtrrndsGIYLCGAIslhp-kakiEESPGAELVV 111 house mouse
1DQT_A     80 QglravdtGLYLCKVElmypppyfvGMGNGTQIYV 114 house mouse
P10966    104 TsvkpedsGIYFCMIVgsp----elTFGKGTQLSV 134 human
CAA81258  102 NrlhgsdnGTYYCCTIqss----qlILGTGTQLDV 132 chicken
NP_998927 103 RhvkpadsGNYFCMAVgnp----elTFGKGTRLSV 133 pig
1I8L_C     82 QglramdtGLYICKVElmypppyylGIGNGAQIYV 116 human
1AH1_A     81 QglramdtGLYICKVElmypppyylGIGNGTQIYV 115 human

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