2DQ7


Conserved Protein Domain Family
PTKc_Fyn_Yrk

?
cd05070: PTKc_Fyn_Yrk (this model, PSSM-Id:133201 is obsolete and has been replaced by 270655)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinases, Fyn and Yrk
Protein Tyrosine Kinase (PTK) family; Fyn and Yrk kinases; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) tyr kinases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury.
Statistics
?
PSSM-Id: 133201
View PSSM: cd05070
Aligned: 6 rows
Threshold Bit Score: 588.895
Threshold Setting Gi: 45384372
Created: 22-May-2007
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ###   #           # #                                          ##
2DQ7_X      4 WEIPRESLQLIKRLGNGQFGEVWMGTWNgNTKVAIKTLKPGTmsPESFLEEAQIMKKLKHDKLVQLYAVVSeePIYIVTE 83  human
P13406    264 WEIPRESLQLIKRLGNGQFGEVWMGTWNgNTKVAIKTLKPGTmsPESFLEEAQIMKKLKHDKLVQLYAVVSeePIYIVTE 343 African clawed frog
CAF06179  264 WEIPRESLQLIKRLGNGQFGEVWMGTWNgNTKVAVKTLKPGTmsPESFLEEAQIMKKLRHDKLVQLYAVVSeePIYIVTE 343 zebrafish
Q02977    263 WEIPRESLQLLQKLGNGQFGEVWMGTWNgTTKVAVKTLKPGTmsPEAFLEEAQIMKRLRHDKLVQLYAVVSeePIYIVTE 342 chicken
AAH81616  255 WEIPRESLQLIKKLGNGQFGEVWMGMWNgTTKVAVKTLKPGTmsPEAFLDEAQIMKRLRHDKLVQLYAVVSeePIYIITE 334 zebrafish
NP_990680 261 WEVARDSLFLEQKLGQGCFAEVWRGTWNgNTKVAIKTLKPGTmsPESFLEEAQIMKKLKHDKLVQLYAVVSrrPIYIVTE 340 chicken
Feature 1     ##   #                                        #   ## #          #               
2DQ7_X     84 YMnKGSLLDFLKdgegraLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEXTAR 163 human
P13406    344 YMsKGSLLDFLKdgegraLKLPNLVDMAAQVARGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 423 African clawed frog
CAF06179  344 YMsKGSLLDFLKdgegrgLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTAR 423 zebrafish
Q02977    343 FMsQGSLLDFLKdgdgryLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTAR 422 chicken
AAH81616  335 FMsQGSLLDFLKdgdgrnLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLARLIEDNEYTAR 414 zebrafish
NP_990680 341 YMsKGSLLIFLKdgegraLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR 420 chicken
Feature 1      #####        #                                 #                               
2DQ7_X    164 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKgRVPYPGMNNREVLEQVERGYRMPCPQDcPISLHELMIHCW 243 human
P13406    424 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKgRVPYPGMNNREVLEQVERGYRMPCPQDcPISLHELMLNCW 503 African clawed frog
CAF06179  424 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKgRVPYPGMNNREVLEQVERGYRMPCPQDcPSSLHELMLQCW 503 zebrafish
Q02977    423 QGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTELVTKgRVPYPGMNNREVLEQVERGYRMQCPGGcPPSLHDVMVQCW 502 chicken
AAH81616  415 QGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKgRVPYPGMNNREVLEQVERGYRMPCPQGsPASLHELMLQCW 494 zebrafish
NP_990680 421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKgRVPYPGMNNREVLEQVERGYRMPCPQDcPISLHELMIHCW 500 chicken
Feature 1                         
2DQ7_X    244 KKdPEERPTFEYLQSFLEDY 263 human
P13406    504 KKdPEERPTFEYLQGFLEDY 523 African clawed frog
CAF06179  504 KRdPEERPTFEYLQAFLEDY 523 zebrafish
Q02977    503 KRePEERPTFEYLQSFLEDY 522 chicken
AAH81616  495 RKdPDERHTFEYLQSFLEDY 514 zebrafish
NP_990680 501 KKdPEERPTFEYLQGFLEDY 520 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap