Conserved Protein Domain Family
PTKc_Frk_like

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cd05068: PTKc_Frk_like (this model, PSSM-Id:133199 is obsolete and has been replaced by 270653)
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
Protein Tyrosine Kinase (PTK) family; Human Fyn-related kinase (Frk) and similar proteins; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) tyr kinases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life.
Statistics
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PSSM-Id: 133199
View PSSM: cd05068
Aligned: 11 rows
Threshold Bit Score: 527.764
Threshold Setting Gi: 17508235
Created: 22-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     # ###   #           # #                                           #
gi 4503787   227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNnTTPVAVKTLKPGSmdPNDFLREAQIMKNLRHPKLIQLYAVCTledPIYIIT 306
gi 17508235  233 WEVDRRSVRLIRQIGAGQFGEVWEGRWNvNVPVAVKKLKAGTadPTDFLAEAQIMKKLRHPKLLSLYAVCTrdePILIVT 312
gi 1174436   233 WEIEKTQIKLLRRLGAGQFGEVWEGLWNgTTSVAVKTLKPGTmsVEEFLQEASIMKRLRHPKLIQLYAVCTkeePIYIVT 312
gi 1174437    88 WEISRDSITLIRKLGAGQFGEVYQGLWNnSTPVAVKTLKAGTmqPAAFLAEAQIMKKLRHPKLIQLYAVCTqgePVYIIT 167
gi 41352675  245 WEIPRNSLQMVKRLGGGQFGEVWEGLWNnTTPVAIKTLKPGTmnEDDFLKEAQIMKKLRHPKLIQLYAVCTmeePMYIVT 324
gi 18146648  253 WEIERTSIQLKRRLGAGQFGEVWEGVWNgTTPVAVKTLKAGTmaASEFLAEAQVMKKLQHEKLIQLYAVCTkeePIYIVT 332
gi 32264368  104 WEIPRKSIELKSKLGSGQFGDVWRGVWNkTTEVAVKTLKPGSmsAEEFLKEAGVMKRLRHPKLIQLYAVCTdkePIYIVT 183
gi 1174438    59 WEIDRTTIQLQRKLGQGNFGEVWAGVWNgTTAVAVKTLKPDTmeVKDFVQEAQVMKKIHHPNLLQLYAVCTigePIYIVT 138
gi 33112450  241 WEIDRTSLKFVRKLGSGQFGDVWEGLWNnTTPVAIKTLKSGTmdPKDFLAEAQIMKKLRHTKLIQLYAVCTveePIYIIT 320
gi 47213587  249 WEIDRKSIKLLRKLGAGQFGEVFEGLWNdTTPVAVKTLKPGTmdPEDFLREAQIMKRLRHAKLIQLYAVCTledPIYIIT 328
gi 118088653 279 WEIDRKSLKFLKKLGSGQFGEVWEGLWNnTTPVAIKTLKPGSmdPKDFLREAQIMKNLRHPNLIQLYAVCTledPIYIVT 358
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###   #                                          #   ## #          #            
gi 4503787   307 ELMrHGSLQEYLQndt--gskIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKvdnE 384
gi 17508235  313 ELM-QENLLTFLQrrg---rqCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMk--E 386
gi 1174436   313 ELMkYGSLLEYLRged---gvLKIEQLVDVAAQVASGMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVID---E 386
gi 1174437   168 ELMsKGSLLDYLQgea---gaLKLPQLIDMAAQVAAGMAYLELHNYIHRDLAARNILVGDNNICKVADFGLARLIV---S 241
gi 41352675  325 ELMiNGALLDFLQtsk--grmLKLPELIGTASQVASGMAYLEKQSYIHRDLAARNVLVGESNICKVADFGLARIIK---D 399
gi 18146648  333 ELMkNGSLLDYLQkge--grhMKLEELIDVSAQVASGMAYLEAQHYIHRDLAARNILVGEANIVKIADFGLARVIK---D 407
gi 32264368  184 ELMkNGSLLDYLHdkg---raLNLPQLVDMAAQVASGMAYLEAQNFVHRDLAARNVLVGDNNTCKVGDFGLSRVLGq--E 258
gi 1174438   139 ELMkYGSMLEYLKhge--gknITLHQMVDMSAQIASGMTYLEAHSYIHRDLAARNILVGEGNVCKVADFGLARVIK---E 213
gi 33112450  321 ELMkHGSLLEYLQaiagkgrsLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK---E 397
gi 47213587  329 ELMkYGSLLDYLQknk--gttLQISDQIEMAAQVASGMAFLELQNYIHRDLAARNVLVGENNICKVADFGLARVFMvdnE 406
gi 118088653 359 ELMkYGSLIEYLQnda--gshISLPHQIDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHSVYKVADFGLARVFKvenE 436
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #####        #                                 #                         
gi 4503787   385 DIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYgKMPYSGMTGAQVIQMLAQNYRLPQPSNcPQQFYN 464
gi 17508235  387 NEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFgRLPYPGMTNAEVLQQVDAGYRMPCPAGcPVTLYD 466
gi 1174436   387 EIYEAHTGAKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYgRFPYPGMTNPEVLEKIQQNYRMPCPANcPKQFHD 466
gi 1174437   242 DDYNATEGAKFPIKWTAPEAALFNRFSIKSDVWSFGILITELVTYgRIPYPGMSNAEVLQNLDKGYRMPCPVTtPESLYQ 321
gi 41352675  400 DIYESRVGAKFPIKWTAPEAANYLAFTIKSDVWSFGILLTEIVTYgRIPYAGYTNKQVLDMVETGFRMPCPPGcPPELYD 479
gi 18146648  408 DEYTAREGAKFPIKWTAPEAALFSRFSIKSDVWSFGVLLVELVTHgRVPYPGMTNGEVLAKVEQGYRMPPPPGcPDALYQ 487
gi 32264368  259 SEYTAREGAKFPIKWTAPEAALMNRFSIKSDVWAFGILLTELVTYgRIPYPGMTNAEVLQQVERGYRMPAPTNcPPELYN 338
gi 1174438   214 DIYNPREGTKFPIKWTAPEAALYNRFTIKSDVWSFGVLISEIVTHgRMPYPGMTNRQVLEAVDRGYRMPCPEGcPDPLYK 293
gi 33112450  398 DEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYgRIPYPGMTNAEVLTQVEHGYRMPQPPNcEPRLYE 477
gi 47213587  407 NVYEAREGTKFPVKWTAPEAIHSNKFSIKSDVWSFGILLYEIMTFgQMPYPTMTNLQVVQKVPQGYRMPCPPScPKVLYD 486
gi 118088653 437 NIYEARPETKLPVKWTAPEAIRYNKFSVKSDVWSFGILLFEIITYgKMPYAGMPGHQVIQMLDKGYRLPQPETcPKALYE 516
                        250       260
                 ....*....|....*....|....*.
Feature 1                                  
gi 4503787   465 IMLECWNAePKERPTFETLRWKLEDY 490
gi 17508235  467 IMQQCWRSdPDKRPTFETLQWKLEDL 492
gi 1174436   467 IMLDCWREdPASRPTFETLQWQLEEF 492
gi 1174437   322 IMLDCWKRnPADRPTFEALQWRLEDF 347
gi 41352675  480 IMLECWKAtPLDRPTFETLQWKLEEF 505
gi 18146648  488 IMLDCWKPeADERPTFEYLKFTLEDY 513
gi 32264368  339 IMLDCWKFkPDERPTFETLQYRLEDF 364
gi 1174438   294 IMLSCWKHePDDRPTFESLKNLLEDY 319
gi 33112450  478 IMLECWHKdPMRRPTFETLQWKLEDF 503
gi 47213587  487 IMTECWKEdEQDRPTFETLQWKLEDF 512
gi 118088653 517 LMLKCWSTePSERPTFEALYCQLEDY 542

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