1XBC,1U59


Conserved Protein Domain Family
PTKc_Syk_like

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cd05060: PTKc_Syk_like (this model, PSSM-Id:133191 is obsolete and has been replaced by 270650)
Click on image for an interactive view with Cn3D
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases
Protein Tyrosine Kinase (PTK) family; Spleen Tyrosine Kinase (Syk) subfamily; catalytic (c) domain. The Syk subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk subfamily kinases are cytoplasmic (or nonreceptor) tyr kinases containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor (BCR) signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity.
Statistics
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PSSM-Id: 133191
View PSSM: cd05060
Aligned: 8 rows
Threshold Bit Score: 461.434
Threshold Setting Gi: 56554456
Created: 17-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #####   #                   # #                              #              ##
1XBC_A         23 KELGSGNFGTVKKGYYQMKk-----vVKTVAVKILKNEAndpalKDELLAEANVMQQLDNPYIVRMIGICEaeSWMLVME 97   human
1U59_A         16 IELGCGNFGSVRQGVYRMRk-----kQIDVAIKVLKQGTek-adTEEMMREAQIMHQLDNPYIVRLIGVCQaeALMLVME 89   human
AAC28629      361 HELGHGNFGSVVKGVYLLKnn----kSVAVAVKTLKEEDip-gqKSEIVKEAEIMSKLDHPNIVRLIGVTQspGFMLVME 435  Hydra vulgaris
BAA81723      290 GELGAGTFGTVRLGVYRPKng---epEVQCALKYLKQSEelpnqKAEILREADAMAALDHCNIVRLFGICVgdPICLVME 366  Ephydatia flu...
CAD13249      892 ERLGGGNFGHVVKGLYRTPsg----qEVPVAVKTLKPNQiansgEREILAEARTMAQLKHRHIVRLIGVCKeeQFMLVLE 967  Schistosoma m...
1022831       666 REIGHGEFGSVHSGWLLRKsgageesRLEVAIKMLSDEHs---nKQEFLREASVMMRLEHKCIVRLIGISKgeMLMMVQE 742  fruit fly
1708331       488 KELGVGEFGSVIKGIWLSPgg----kEINVAMKTLHKDKmv-qgEKEFLREALVMSQLNHPCIVSLLGVCLgpPMILVQE 562  Hydra vulgaris
XP_001180232  567 NEIGQGEFGSVLEGKYKEKd-----rWVKVALKTLHADHlq-tgQKEFLREAKVMCGLDHPCIVKLMGVCLgpPMMLVQE 640  purple urchin
Feature 1         ##  ##                                        #   ## #         ##               
1XBC_A         98 MAELGPLNKYLQQNr--hVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTqHYAKISDFGLSKALRADENYYK 175  human
1U59_A         90 MAGGGPLHKFLVGKre-eIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNrHYAKISDFGLSKALGADDSYYT 168  human
AAC28629      436 LAPQGPLHKFLKKNr--nMNVLDILVLMLQVDEGMNYLESQHFVHRDLAARNVLVVSeNFVKISDFGMSRAMGVGNEYYR 513  Hydra vulgaris
BAA81723      367 LARQGPLNKFLRKRp--tFPVIKILNMALQVSRGMAYLEEVRFVHRDLAARNVLVVDdDNVKISDFGMSRAIGAGSEYYK 444  Ephydatia flu...
CAD13249      968 LAPLGPINKYLKKRp--dVSVHTLTELMHQVALGMAYLESCKFVHRDLAARNVLLVTrHFAKISDFGMSKALNFGSDYYR 1045 Schistosoma m...
1022831       743 LAPLGSMLQYILDHgheiTANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTArHQAKISDFGMSRSLRPGSTEYQ 822  fruit fly
1708331       563 LVEMGALLDYLMDYqp-eIQEVDLKLWASQIAFGMMYLELKRFVHRDLAARNILLANkKQVKISDFGLSRAVGTGSDYYQ 641  Hydra vulgaris
XP_001180232  641 LVSQGALLDFLQNDs---ITASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENkGQAKISDFGLSRATGANNDYYR 717  purple urchin
Feature 1            #####        #                                 #                             
1XBC_A        176 AQTHGKWPVKWYAPECINYyKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 255  human
1U59_A        169 ARSAGKWPLKWYAPECINFrKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 248  human
AAC28629      514 AERAGKWPLKWYAPECIYYhKFSSKGDVWSYGITMWEAVSYGGKPYQGMRGPVIVEKLESGYRLPKPDNCSDAVYTLMLK 593  Hydra vulgaris
BAA81723      445 AETAGRWPLKWYAPECIYYaKFDSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLEGNQRLDSPEKCPQPIYDIMLR 524  Ephydatia flu...
CAD13249     1046 AATAGKWPLKWYAPECIYYfRFDSKSDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQGLRLSRPSRCPESIYSIMQQ 1125 Schistosoma m...
1022831       823 FTQGGRWPIRWYAPESFNLgIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYPVMQS 902  fruit fly
1708331       642 AKQGGRWPVRWYAPESINYgTFSTKSDVWSYGITLWEMFTFGDLPYGEMTGNEVVSFLEHCGRLEKPDECPIHTYSIMLS 721  Hydra vulgaris
XP_001180232  718 STTGGRWPVKWYAPESIYYgTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQIMNK 797  purple urchin
Feature 1                                 
1XBC_A        256 CWTYdVENRPGFAAVELRLRNYYY 279  human
1U59_A        249 CWIYkWEDRPDFLTVEQRMRACYY 272  human
AAC28629      594 CWETnPDDRPSFMEIGIILAQYIQ 617  Hydra vulgaris
BAA81723      525 CWAWrPEDRPSFSELSSMLKDIYV 548  Ephydatia fluviatilis
CAD13249     1126 CWNFeGVHRPTFAELVLTISRILR 1149 Schistosoma mansoni
1022831       903 CWKErPKDRPTFVYLTEFFARDPD 926  fruit fly
1708331       722 CWHIdPNKRPTFNELHSTFSTDPE 745  Hydra vulgaris
XP_001180232  798 CWSYkPCNRPTFSQLNDMFRDDPE 821  purple urchin

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