Conserved Protein Domain Family
PTKc_Ror

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cd05048: PTKc_Ror (this model, PSSM-Id:133179 is obsolete and has been replaced by 270642)
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors
Protein Tyrosine Kinase (PTK) family; Receptor tyrosine kinase-like Orphan Receptor (Ror) subfamily; catalytic (c) domain. The Ror subfamily consists of Ror1, Ror2, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror proteins are orphan receptor tyr kinases (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions.
Statistics
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PSSM-Id: 133179
View PSSM: cd05048
Aligned: 6 rows
Threshold Bit Score: 509.304
Threshold Setting Gi: 121582134
Created: 15-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #####   #                  # #                                      
gi 118572711  467 ELPLSAVRFMEELGECAFGKIYKGHLylpg--mdhaQLVAIKTLKDYNnpqqWTEFQQEASLMAELHHPNIVCLLGAVTq 544
gi 13430037   565 EFPMPNIRFLQELGEGAFGKVYKGELvglyg-essvTTVAIKTLKENAlpkvQNDFRREVDLMSDMRHPNIVCLLGVCMk 643
gi 27923846   404 HFTLQDVEFLEELGEGAFGKVYKGQLlqpn---kttITVAIKALKENAsvktQQDFKREIELISDLKHQNIVCILGVVLn 480
gi 13633870   467 EISLSTVRFMEELGEDRFGKVYKGHLfgpap-geptQAVAIKTLKDKAegplREEFRQEAMLRARLQHPNIVCLLGVVTk 545
gi 115921052  706 EIPLAAIKFSEALGDGTFGKVWRGELmglnn-qyscTSIVIKTLDKEAspalQQDYRNETSVMASLNHPNIITLLGVCTk 784
gi 121582134  433 REIKESLRLLKELGEGDYGKVYFGEIttksegrlmaTSVLVVSLRESHevdvRDEFFEKAEAWSKLQHPNIITIVGMCNk 512
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ####  ##                                                        #   ## # 
gi 118572711  545 eqPVCMLFEYINQGDLHEFLIMRSPhsdvgcssd-edgtvkssLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI 623
gi 13430037   644 qePMCMLFEYMAQGDLHEYLLSHSPhsdvtaaeddsgtggghiLEYSEMLHVSTQVAAGMEYLASHHFVHRDLAARNILV 723
gi 27923846   481 kePYCMLFEYMANGDLHEFLISNSPteg-------------ksLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLV 547
gi 13633870   546 dqPLSMIFSYCSHGDLHEFLVMRSPhsdvgstd--ddrtvksaLEPPDFVHVVAQIAAGMEFLSSHHVCHKDLATRNVLV 623
gi 115921052  785 ekPNCMLFEFLPHGDLHEFLVRHSPnsdvgfgs--gdddtqssLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMV 862
gi 121582134  513 svPTCVLYEYLEYGTLHEYLVRNAPiddpeae-----eeiadpLWCDGLISIAYQVAAGMNYLSSNNIVHGDLATRNCMV 587
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #                 #####        #                                 #     
gi 118572711  624 GEqLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIE 703
gi 13430037   724 ADgLTVKISDFGLSRDVYSSDYYRVQSKSLLPVRWMPPEAILYGKFTTDSDVWAFGVVLWEVFSYGLQPYYGFSNQEVIE 803
gi 27923846   548 NEgLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVIN 627
gi 13633870   624 YDkLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVE 703
gi 115921052  863 GEhHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRFTVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIE 942
gi 121582134  588 GPgRTVKITDVALTRLGYSHDYYRQLHRRPLPVRWMAPEAILSYRFTPETDIWSFGVLLWELFSYGAQPHFGFSNEDVMF 667
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
Feature 1                                                       
gi 118572711  704 MVRKRQLLPCSEDCpPRMYSLMTECWNEiPSRRPRFKDIHVRLRSW 749
gi 13430037   804 MIRSRQILGCPEECpARIYGLMVECWHEmPARRPPFREIHTRLRTW 849
gi 27923846   628 LIRSRQLLSAPENCpTAVYSLMIECWHEqSVKRPTFTDISNRLKTW 673
gi 13633870   704 MIRSRQVLPCPDDCpAWVYALMIECWNEfPSRRPRFKDIHSRLRSW 749
gi 115921052  943 MIRTRHILPSPSGCpQYIYALMTECWSEiPARRPPFKVISTRLRAL 988
gi 121582134  668 RLRECILLPCPVDCpASVYRLMKECWDIlPPSRPRFSTIHTHLGVL 713

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