Conserved Protein Domain Family
PTKc_Ror

?
cd05048: PTKc_Ror (this model, PSSM-Id:133179 is obsolete and has been replaced by 270642)
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors
Protein Tyrosine Kinase (PTK) family; Receptor tyrosine kinase-like Orphan Receptor (Ror) subfamily; catalytic (c) domain. The Ror subfamily consists of Ror1, Ror2, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror proteins are orphan receptor tyr kinases (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions.
Statistics
?
PSSM-Id: 133179
Aligned: 6 rows
Threshold Bit Score: 509.304
Created: 15-Aug-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                  #####   #                  # #                                      
Q01973     467 ELPLSAVRFMEELGECAFGKIYKGHLylpg--mdhaQLVAIKTLKDYNnpqqWTEFQQEASLMAELHHPNIVCLLGAVTq 544  human
AAK25726   565 EFPMPNIRFLQELGEGAFGKVYKGELvglyg-essvTTVAIKTLKENAlpkvQNDFRREVDLMSDMRHPNIVCLLGVCMk 643  California sea hare
Q24488     404 HFTLQDVEFLEELGEGAFGKVYKGQLlqpn---kttITVAIKALKENAsvktQQDFKREIELISDLKHQNIVCILGVVLn 480  fruit fly
Q9Z138     467 EISLSTVRFMEELGEDRFGKVYKGHLfgpap-geptQAVAIKTLKDKAegplREEFRQEAMLRARLQHPNIVCLLGVVTk 545  house mouse
XP_792459  706 EIPLAAIKFSEALGDGTFGKVWRGELmglnn-qyscTSIVIKTLDKEAspalQQDYRNETSVMASLNHPNIITLLGVCTk 784  purple urchin
BAF44474   433 REIKESLRLLKELGEGDYGKVYFGEIttksegrlmaTSVLVVSLRESHevdvRDEFFEKAEAWSKLQHPNIITIVGMCNk 512  starlet sea anemone
Feature 1             ####  ##                                                        #   ## # 
Q01973     545 eqPVCMLFEYINQGDLHEFLIMRSPhsdvgcssd-edgtvkssLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI 623  human
AAK25726   644 qePMCMLFEYMAQGDLHEYLLSHSPhsdvtaaeddsgtggghiLEYSEMLHVSTQVAAGMEYLASHHFVHRDLAARNILV 723  California sea hare
Q24488     481 kePYCMLFEYMANGDLHEFLISNSPteg-------------ksLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLV 547  fruit fly
Q9Z138     546 dqPLSMIFSYCSHGDLHEFLVMRSPhsdvgstd--ddrtvksaLEPPDFVHVVAQIAAGMEFLSSHHVCHKDLATRNVLV 623  house mouse
XP_792459  785 ekPNCMLFEFLPHGDLHEFLVRHSPnsdvgfgs--gdddtqssLDASDFLNIAIQIVSGMDYLSSRHFVHRDLAARNCMV 862  purple urchin
BAF44474   513 svPTCVLYEYLEYGTLHEYLVRNAPiddpeae-----eeiadpLWCDGLISIAYQVAAGMNYLSSNNIVHGDLATRNCMV 587  starlet sea anemone
Feature 1               #                 #####        #                                 #     
Q01973     624 GEqLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIE 703  human
AAK25726   724 ADgLTVKISDFGLSRDVYSSDYYRVQSKSLLPVRWMPPEAILYGKFTTDSDVWAFGVVLWEVFSYGLQPYYGFSNQEVIE 803  California sea hare
Q24488     548 NEgLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVIN 627  fruit fly
Q9Z138     624 YDkLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVE 703  house mouse
XP_792459  863 GEhHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRFTVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIE 942  purple urchin
BAF44474   588 GPgRTVKITDVALTRLGYSHDYYRQLHRRPLPVRWMAPEAILSYRFTPETDIWSFGVLLWELFSYGAQPHFGFSNEDVMF 667  starlet sea anemone
Feature 1                                                    
Q01973     704 MVRKRQLLPCSEDCpPRMYSLMTECWNEiPSRRPRFKDIHVRLRSW 749  human
AAK25726   804 MIRSRQILGCPEECpARIYGLMVECWHEmPARRPPFREIHTRLRTW 849  California sea hare
Q24488     628 LIRSRQLLSAPENCpTAVYSLMIECWHEqSVKRPTFTDISNRLKTW 673  fruit fly
Q9Z138     704 MIRSRQVLPCPDDCpAWVYALMIECWNEfPSRRPRFKDIHSRLRSW 749  house mouse
XP_792459  943 MIRTRHILPSPSGCpQYIYALMTECWSEiPARRPPFKVISTRLRAL 988  purple urchin
BAF44474   668 RLRECILLPCPVDCpASVYRLMKECWDIlPPSRPRFSTIHTHLGVL 713  starlet sea anemone

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap