Conserved Protein Domain Family
STKc_MEKK3_like_1

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cd06653: STKc_MEKK3_like_1 (this model, PSSM-Id:132984 is obsolete and has been replaced by 270819)
Catalytic domain of MAP/ERK kinase kinase 3-like Protein Serine/Threonine Kinases
Serine/threonine kinases (STKs), MAP/ERK kinase kinase 3 (MEKK3)-like subfamily, catalytic (c) domain, functionally uncharacterized subgroup 1. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. The MEKK3-like subfamily is composed of MEKK3, MEKK2, and related proteins, all containing an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs or MAP3Ks), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates extracellular signal-regulated kinase 5 (ERK5). The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs.
Statistics
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Aligned: 3 rows
Threshold Bit Score: 584.68
Threshold Setting Gi: 47223394
Created: 29-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #####   #            # #                                 #             
CAG31279  354 PVNWRLGKLLGRGAFGEVYLCYDADTGRELSVKQVPFDPDSQETSKEVNALECEIQLLKTLRHDRIVQYYGCLRDpeeRK 433 chicken
CAG04255  299 PVNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPGCQETSKEVNALECEIQLLKNLRHERIVQYYGCLRDheqKK 378 Tetraodon nigrovir...
AAH90230  351 PENWRLGKLLGRGAFGEVYLCYDVDTGRELAVKQVPFDPDSQETSKEVNALECEIQLLKLHRHDRIVQYYGCLRDpteKK 430 African clawed frog
Feature 1         #### ###  #                                   # #### #         ### #        
CAG31279  434 LSIFVEYMPGGSIKDQLKAYGALTENVTRKYTRQILQGVFYLHsNMIVHRDIKGANILRDSaGNVKLGDFGASKRIQTIC 513 chicken
CAG04255  379 LTIFVEFMPGGSVKDQLKAYGALTEKVTRRYTRQILQGVSYLHsNMIVHRDIKGANILRDSsGNVKLGDFGASKRIQTIY 458 Tetraodon nigrovir...
AAH90230  431 LSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHgNMIVHRDIKGANILRDSaGNVKLGDFGASKRIQTIC 510 African clawed frog
Feature 1             #### #                          #        #                              
CAG31279  514 MSGTGIKSVTGTPYWMSPEVISGEgyGRKADVWSVACTVVEMLTeKPPWAEFEAMAAIFKIATQPTNPQLPDGvsSSCRN 593 chicken
CAG04255  459 MSGTGIKSVTGTPYWMSPEVINGEgyGRKADVWSVACTVVEMLTqKPPWAEYEAMAAIFKIATQPTKPMLPEGvtDACRD 538 Tetraodon nigrovir...
AAH90230  511 MSGTGIKSVTGTPYWMSPEVISGEgyGRKADVWSVACTVVEMLTeKPPWSEYEAMAAIFKIATQPTKPRLPDNvsDACRD 590 African clawed frog
Feature 1                                  
CAG31279  594 FLKQIFVE-----EKRRPTAEDLLRHPFV 617 chicken
CAG04255  539 FLRQLFYWaqrnaEHIVPLYCFDPRHYAG 567 Tetraodon nigroviridis
AAH90230  591 FMKQIFVE-----EKRRPTAEELLRHPFV 614 African clawed frog

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